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Sciatic neuropathy

MedGen UID:
57705
Concept ID:
C0149940
Disease or Syndrome
Synonyms: Nerve Disease, Sciatic; Nerve Diseases, Sciatic; Neuropathies, Sciatic; Neuropathy, Sciatic; Sciatic Nerve Disease; Sciatic Nerve Diseases; Sciatic Neuropathies; Sciatic Neuropathy
SNOMED CT: Sciatic neuropathy (52585001)
 
Monarch Initiative: MONDO:0006960

Definition

Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSciatic neuropathy

Professional guidelines

PubMed

Gharaei H, Gholampoor N
Pain Physician 2023 Sep;26(5):E487-E495. PMID: 37774202
Yürük D, Tabakoğlu AY
Turk J Med Sci 2021 Oct;51(5):2666-2673. Epub 2021 Oct 21 doi: 10.3906/sag-2009-196. PMID: 34365781Free PMC Article
Yamada Y, Laufer I, Cox BW, Lovelock DM, Maki RG, Zatcky JM, Boland PJ, Bilsky MH
Neurosurgery 2013 Oct;73(4):673-80; discussion 680. doi: 10.1227/NEU.0000000000000083. PMID: 23842548

Recent clinical studies

Etiology

Wan L, Su Z, Li F, Gao P, Zhang X
Neurochem Res 2021 Apr;46(4):957-963. Epub 2021 Feb 10 doi: 10.1007/s11064-020-03213-w. PMID: 33566299
De Fine M, Romagnoli M, Zaffagnini S, Pignatti G
Biomed Res Int 2017;2017:8361071. Epub 2017 Nov 15 doi: 10.1155/2017/8361071. PMID: 29270435Free PMC Article
Su EP
Bone Joint J 2017 Jan;99-B(1 Suppl):46-49. doi: 10.1302/0301-620X.99B1.BJJ-2016-0430.R1. PMID: 28042118
Arányi Z, Polyák I, Tóth N, Vermes G, Göcsei Z
Muscle Nerve 2016 Sep;54(3):500-5. Epub 2016 Jul 14 doi: 10.1002/mus.25152. PMID: 27105020
Lai CS, Chen IC, Lan HC, Lu CT, Yen JH, Song DY, Tang YW
Ann Plast Surg 2013 Dec;71 Suppl 1:S37-42. doi: 10.1097/SAP.0000000000000042. PMID: 24284739

Diagnosis

Lo JK, Robinson LR
Handb Clin Neurol 2024;201:203-226. doi: 10.1016/B978-0-323-90108-6.00002-8. PMID: 38697742
Gharaei H, Gholampoor N
Pain Physician 2023 Sep;26(5):E487-E495. PMID: 37774202
Asagai Y, Minamikawa S, Ueshima E, Aida Y, Nakagishi Y
Pediatr Int 2022 Jan;64(1):e15387. doi: 10.1111/ped.15387. PMID: 36239001
Zhu Y, Tsai W, Sokolof J
Am J Phys Med Rehabil 2021 Dec 1;100(12):e198-e199. doi: 10.1097/PHM.0000000000001809. PMID: 34793378
Yuen EC, So YT
Neurol Clin 1999 Aug;17(3):617-31, viii. doi: 10.1016/s0733-8619(05)70155-9. PMID: 10393756

Therapy

Gharaei H, Gholampoor N
Pain Physician 2023 Sep;26(5):E487-E495. PMID: 37774202
Zhu Y, Tsai W, Sokolof J
Am J Phys Med Rehabil 2021 Dec 1;100(12):e198-e199. doi: 10.1097/PHM.0000000000001809. PMID: 34793378
De Fine M, Romagnoli M, Zaffagnini S, Pignatti G
Biomed Res Int 2017;2017:8361071. Epub 2017 Nov 15 doi: 10.1155/2017/8361071. PMID: 29270435Free PMC Article
Shah BS, Yarbrough C, Price A, Biswas R
BMJ Case Rep 2016 Mar 1;2016 doi: 10.1136/bcr-2015-211127. PMID: 26931130Free PMC Article
Ahuja B, Dhamija K
Indian Pediatr 1984 Oct;21(10):797-801. PMID: 6526488

Prognosis

Hayat G, Calvin JS
Neurol Clin 2021 Nov;39(4):957-981. Epub 2021 Sep 3 doi: 10.1016/j.ncl.2021.06.005. PMID: 34602221
Su EP
Bone Joint J 2017 Jan;99-B(1 Suppl):46-49. doi: 10.1302/0301-620X.99B1.BJJ-2016-0430.R1. PMID: 28042118
Arányi Z, Polyák I, Tóth N, Vermes G, Göcsei Z
Muscle Nerve 2016 Sep;54(3):500-5. Epub 2016 Jul 14 doi: 10.1002/mus.25152. PMID: 27105020
Stewart JD
Pract Neurol 2008 Jun;8(3):158-69. doi: 10.1136/jnnp.2008.149393. PMID: 18502948
Yuen EC, So YT
Neurol Clin 1999 Aug;17(3):617-31, viii. doi: 10.1016/s0733-8619(05)70155-9. PMID: 10393756

Clinical prediction guides

Koc I, Shafiyev J, Ozturk B, Odabasi Z
Ideggyogy Sz 2022 Nov 30;75(11-12):429-432. doi: 10.18071/isz.75.0429. PMID: 36541143
Kukutla P, Ahmed SG, DuBreuil DM, Abdelnabi A, Cetinbas M, Fulci G, Aldikacti B, Stemmer-Rachamimov A, Plotkin SR, Wainger B, Sadreyev RI, Brenner GJ
Ann Clin Transl Neurol 2021 Jul;8(7):1508-1514. Epub 2021 May 30 doi: 10.1002/acn3.51386. PMID: 34053190Free PMC Article
Wan L, Su Z, Li F, Gao P, Zhang X
Neurochem Res 2021 Apr;46(4):957-963. Epub 2021 Feb 10 doi: 10.1007/s11064-020-03213-w. PMID: 33566299
Cai W, Zhang Y, Liu Y, Liu H, Zhang Z, Su Z
Biochem Biophys Res Commun 2019 Sep 24;517(3):532-537. Epub 2019 Jul 31 doi: 10.1016/j.bbrc.2019.07.061. PMID: 31376943
Stewart JD
Pract Neurol 2008 Jun;8(3):158-69. doi: 10.1136/jnnp.2008.149393. PMID: 18502948

Recent systematic reviews

Dinh J, Wilson TJ
Acta Neurochir (Wien) 2024 May 23;166(1):227. doi: 10.1007/s00701-024-06109-8. PMID: 38780668
Adib F, Posner AD, O'Hara NN, O'Toole RV
Injury 2022 Mar;53(3):1209-1217. Epub 2021 Sep 17 doi: 10.1016/j.injury.2021.09.019. PMID: 34602242
De Fine M, Romagnoli M, Zaffagnini S, Pignatti G
Biomed Res Int 2017;2017:8361071. Epub 2017 Nov 15 doi: 10.1155/2017/8361071. PMID: 29270435Free PMC Article
Giannoudis PV, Kontakis G, Christoforakis Z, Akula M, Tosounidis T, Koutras C
Injury 2009 Dec;40(12):1245-51. Epub 2009 Nov 7 doi: 10.1016/j.injury.2009.10.024. PMID: 19897188

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