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Neonatal aspiration of amniotic fluid

MedGen UID:
578768
•Concept ID:
C0349470
•
Disease or Syndrome
Synonyms: Aspiration of amniotic fluid in newborn; Aspiration of liquor in newborn; Neonatal Aspiration of Amniotic Fluid; Neonatal aspiration of liquor
SNOMED CT: Neonatal aspiration of amniotic fluid (276540001); Aspiration of amniotic fluid in newborn (276540001); Aspiration of liquor in newborn (276540001); Neonatal aspiration of liquor (276540001)

Definition

Inhalation of fluid from the amniotic sac into the lungs by the neonate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal aspiration of amniotic fluid

Professional guidelines

PubMed

Current Concepts in the Management of Meconium Aspiration Syndrome.
Chettri S, Bhat BV, Adhisivam B
Indian J Pediatr 2016 Oct;83(10):1125-30. Epub 2016 May 21 doi: 10.1007/s12098-016-2128-9. PMID: 27206687
Pigtail catheters used in the treatment of pneumothoraces in the neonate.
Cates LA
Adv Neonatal Care 2009 Feb;9(1):7-16. doi: 10.1097/01.ANC.0000346089.97615.71. PMID: 19212159
Management of meconium-stained amniotic fluid.
Wiswell TE, Fuloria M
Clin Perinatol 1999 Sep;26(3):659-68. PMID: 10494471

Recent clinical studies

Etiology

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
What is the role of amnioinfusion in modern day obstetrics?
Dad N, Abushama M, Konje JC, Ahmed B
J Matern Fetal Neonatal Med 2016 Sep;29(17):2823-7. Epub 2015 Dec 2 doi: 10.3109/14767058.2015.1105953. PMID: 26461043
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Diagnosis

Meconium "aspiration" (or respiratory distress associated with meconium-stained amniotic fluid?).
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
What is the role of amnioinfusion in modern day obstetrics?
Dad N, Abushama M, Konje JC, Ahmed B
J Matern Fetal Neonatal Med 2016 Sep;29(17):2823-7. Epub 2015 Dec 2 doi: 10.3109/14767058.2015.1105953. PMID: 26461043
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Neonatal listeriosis.
Ahlfors CE, Goetzman BW, Halsted CC, Sherman MP, Wennberg RP
Am J Dis Child 1977 Apr;131(4):405-8. doi: 10.1001/archpedi.1977.02120170031005. PMID: 322474

Therapy

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Prognosis

Prediction of adverse neonatal outcome among newborns born through meconium-stained amniotic fluid.
Levin G, Tsur A, Shai D, Cahan T, Shapira M, Meyer R
Int J Gynaecol Obstet 2021 Sep;154(3):515-520. Epub 2021 Feb 11 doi: 10.1002/ijgo.13592. PMID: 33448026
Meconium "aspiration" (or respiratory distress associated with meconium-stained amniotic fluid?).
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Amnioinfusion for meconium-stained liquor in labour.
Hofmeyr GJ, Xu H, Eke AC
Cochrane Database Syst Rev 2014 Jan 23;2014(1):CD000014. doi: 10.1002/14651858.CD000014.pub4. PMID: 24453049Free PMC Article
Maternal and neonatal outcomes of elective induction of labor.
Caughey AB, Sundaram V, Kaimal AJ, Cheng YW, Gienger A, Little SE, Lee JF, Wong L, Shaffer BL, Tran SH, Padula A, McDonald KM, Long EF, Owens DK, Bravata DM
Evid Rep Technol Assess (Full Rep) 2009 Mar;(176):1-257. PMID: 19408970Free PMC Article
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962

Clinical prediction guides

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Prediction of adverse neonatal outcome among newborns born through meconium-stained amniotic fluid.
Levin G, Tsur A, Shai D, Cahan T, Shapira M, Meyer R
Int J Gynaecol Obstet 2021 Sep;154(3):515-520. Epub 2021 Feb 11 doi: 10.1002/ijgo.13592. PMID: 33448026
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Recent systematic reviews

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections.
Siriwachirachai T, Sangkomkamhang US, Lumbiganon P, Laopaiboon M
Cochrane Database Syst Rev 2014 Nov 6;2014(11):CD007772. doi: 10.1002/14651858.CD007772.pub3. PMID: 25374369Free PMC Article
Maternal and neonatal outcomes of elective induction of labor.
Caughey AB, Sundaram V, Kaimal AJ, Cheng YW, Gienger A, Little SE, Lee JF, Wong L, Shaffer BL, Tran SH, Padula A, McDonald KM, Long EF, Owens DK, Bravata DM
Evid Rep Technol Assess (Full Rep) 2009 Mar;(176):1-257. PMID: 19408970Free PMC Article

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