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Secondary antiphospholipid syndrome

MedGen UID:
592743
•Concept ID:
C0409983
•
Disease or Syndrome
Synonym: secondary antiphospholipid syndrome
SNOMED CT: Secondary antiphospholipid syndrome (239895006)
 
Monarch Initiative: MONDO:0021008

Definition

An antiphospholipid syndrome that occurs alongside another autoimmune disorder. [from MONDO]

Professional guidelines

PubMed

Diffuse Alveolar Hemorrhage in Primary Versus Secondary Antiphospholipid Syndrome.
Sangli SS, Ryu JH, Baqir M
J Clin Rheumatol 2021 Dec 1;27(8):e297-e301. doi: 10.1097/RHU.0000000000001358. PMID: 32195850
Treatment of systemic lupus erythematosus - 2013 update.
Belmont HM
Bull Hosp Jt Dis (2013) 2013;71(3):208-13. PMID: 24151947
Long-term treatment of antiphospholipid syndrome with intravenous immunoglobulin in addition to conventional therapy.
Tenti S, Guidelli GM, Bellisai F, Galeazzi M, Fioravanti A
Clin Exp Rheumatol 2013 Nov-Dec;31(6):877-82. Epub 2013 Aug 2 PMID: 23985161

Recent clinical studies

Etiology

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Antiphospholipid antibodies and idiopathic infertility.
Del Porto F, Ferrero S, Cifani N, Sesti G, Proietta M
Lupus 2022 Mar;31(3):347-353. Epub 2022 Jan 24 doi: 10.1177/09612033221076735. PMID: 35073215
Diffuse Alveolar Hemorrhage in Primary Versus Secondary Antiphospholipid Syndrome.
Sangli SS, Ryu JH, Baqir M
J Clin Rheumatol 2021 Dec 1;27(8):e297-e301. doi: 10.1097/RHU.0000000000001358. PMID: 32195850
Cardiac Manifestations of Antiphospholipid Syndrome With Focus on Its Primary Form.
Kolitz T, Shiber S, Sharabi I, Winder A, Zandman-Goddard G
Front Immunol 2019;10:941. Epub 2019 May 10 doi: 10.3389/fimmu.2019.00941. PMID: 31134062Free PMC Article
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article

Diagnosis

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Nephrogenic Diabetes Insipidus and Distal Renal Tubular Acidosis in a Patient with Systemic Lupus Erythematosus and Secondary Antiphospholipid Syndrome.
Rocha-Rojas R, Flores-Laguna A, Solis G, Flores G
Saudi J Kidney Dis Transpl 2022 Jan-Feb;33(1):185-188. doi: 10.4103/1319-2442.367813. PMID: 36647993
Antiphospholipid antibodies and idiopathic infertility.
Del Porto F, Ferrero S, Cifani N, Sesti G, Proietta M
Lupus 2022 Mar;31(3):347-353. Epub 2022 Jan 24 doi: 10.1177/09612033221076735. PMID: 35073215
Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities?
Belizna C, Stojanovich L, Cohen-Tervaert JW, Fassot C, Henrion D, Loufrani L, Nagy G, Muchardt C, Hasan M, Ungeheuer MN, Arnaud L, Alijotas-Reig J, Esteve-Valverde E, Nicoletti F, Saulnier P, Godon A, Reynier P, Chrétien JM, Damian L, Omarjee L, Mahé G, Pistorius MA, Meroni PL, Devreese K
Autoimmun Rev 2018 Aug;17(8):739-745. Epub 2018 Jun 6 doi: 10.1016/j.autrev.2018.01.027. PMID: 29885541
Antiphospholipid syndrome.
Gezer S
Dis Mon 2003 Dec;49(12):696-741. doi: 10.1016/j.disamonth.2003.10.001. PMID: 14679358

Therapy

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Diffuse Alveolar Hemorrhage in Primary Versus Secondary Antiphospholipid Syndrome.
Sangli SS, Ryu JH, Baqir M
J Clin Rheumatol 2021 Dec 1;27(8):e297-e301. doi: 10.1097/RHU.0000000000001358. PMID: 32195850
Thrombolytic therapy at systemic lupus onset with secondary antiphospholipid syndrome. A rare stroke experience.
Loharia JJ, Alam JM, Abdelhadi HA, Marei TF
Neurosciences (Riyadh) 2015 Jan;20(1):55-60. PMID: 25630783Free PMC Article
Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment.
Giannouli S, Voulgarelis M, Ziakas PD, Tzioufas AG
Ann Rheum Dis 2006 Feb;65(2):144-8. Epub 2005 Aug 3 doi: 10.1136/ard.2005.041673. PMID: 16079164Free PMC Article
Crossing of antinuclear antibodies and anti-leishmania antibodies.
Granel B, Serratrice J, Swiader L, Gambarelli F, Daniel L, Fossat C, Hesse-Bonérandi S, Pache X, Disdier P, Weiller PJ
Lupus 2000;9(7):548-50. doi: 10.1177/096120330000900713. PMID: 11035423

Prognosis

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Systemic lupus erythematosus and secondary antiphospholipid syndrome in native sisters with reduced fertility.
Ulčová-Gallová Zdenka, Mukenšnabl Petr, Dzurillová Žaneta, Lošan Petr
Ceska Gynekol 2022;87(3):198-201. doi: 10.48095/cccg2022198. PMID: 35896399
Diffuse Alveolar Hemorrhage in Primary Versus Secondary Antiphospholipid Syndrome.
Sangli SS, Ryu JH, Baqir M
J Clin Rheumatol 2021 Dec 1;27(8):e297-e301. doi: 10.1097/RHU.0000000000001358. PMID: 32195850
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article
Cardiac abnormalities in SLE: pancarditis.
Bijl M, Brouwer J, Kallenberg GG
Lupus 2000;9(4):236-40. doi: 10.1191/096120300680199006. PMID: 10866093

Clinical prediction guides

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Antiphospholipid antibodies and idiopathic infertility.
Del Porto F, Ferrero S, Cifani N, Sesti G, Proietta M
Lupus 2022 Mar;31(3):347-353. Epub 2022 Jan 24 doi: 10.1177/09612033221076735. PMID: 35073215
Cardiac Manifestations of Antiphospholipid Syndrome With Focus on Its Primary Form.
Kolitz T, Shiber S, Sharabi I, Winder A, Zandman-Goddard G
Front Immunol 2019;10:941. Epub 2019 May 10 doi: 10.3389/fimmu.2019.00941. PMID: 31134062Free PMC Article
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome.
Pelusa HF, Pezzarini E, Basiglio CL, Musuruana J, Bearzotti M, Svetaz MJ, Daniele SM, Bottai H, Arriaga SM
Ann Clin Biochem 2017 Sep;54(5):577-583. Epub 2016 Sep 16 doi: 10.1177/0004563216672248. PMID: 27638930
Crossing of antinuclear antibodies and anti-leishmania antibodies.
Granel B, Serratrice J, Swiader L, Gambarelli F, Daniel L, Fossat C, Hesse-Bonérandi S, Pache X, Disdier P, Weiller PJ
Lupus 2000;9(7):548-50. doi: 10.1177/096120330000900713. PMID: 11035423

Recent systematic reviews

Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis.
Wind M, Fierro JJ, Bloemenkamp KWM, de Leeuw K, Lely AT, Limper M, Sueters M, Teng YKO, Walter IJ, Kooiman J
Lancet Rheumatol 2024 Oct;6(10):e667-e683. Epub 2024 Aug 14 doi: 10.1016/S2665-9913(24)00160-7. PMID: 39153486
Relationship of Antiphospholipid Antibodies to Risk of Dementia: A Systematic Review.
Bucci T, Menichelli D, Pignatelli P, Triggiani M, Violi F, Pastori D
J Alzheimers Dis 2019;69(2):561-576. doi: 10.3233/JAD-181294. PMID: 31104025
Arterial/venous thrombosis, fetal loss and stillbirth in pregnant women with systemic lupus erythematosus versus primary and secondary antiphospholipid syndrome: a systematic review and meta-analysis.
Bundhun PK, Soogund MZS, Huang F
BMC Pregnancy Childbirth 2018 Jun 7;18(1):212. doi: 10.1186/s12884-018-1850-x. PMID: 29879927Free PMC Article

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