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Keratoderma

MedGen UID:: 5955
•Concept ID:: C0022579
•: Disease or Syndrome

SNOMED CT:

Keratoderma (707209001)

Definition

A skin disorder consisting of hypertrophy of the stratum corneum of the skin. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVKeratoderma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Site
        Non-Neoplastic Skin Disorder
        Keratoderma
        Acquired keratosis
        Palmoplantar keratoderma
        Diffuse palmoplantar hyperkeratosis
        Diffuse palmoplantar keratoderma of Thost-Unna
        Palmoplantar keratoderma with leukoplakia
        Palmoplantar keratoderma, epidermolytic
        Type A Tylosis
        Type B Tylosis
        Papillon-Lefèvre syndrome

Professional guidelines

PubMed

Aquagenic Keratoderma: Treatment Update.

Carbonell Pradas M, Grimalt Santacana R
Actas Dermosifiliogr 2022 Mar;113(3):254-260. Epub 2021 Jun 12 doi: 10.1016/j.ad.2021.05.016. PMID: 34126071

Diagnosis and Management of Inherited Palmoplantar Keratodermas.

Thomas BR, O'Toole EA
Acta Derm Venereol 2020 Mar 25;100(7):adv00094. doi: 10.2340/00015555-3430. PMID: 32147745 Free PMC Article

Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis".

Sakiyama T, Kubo A
J Dermatol 2016 Mar;43(3):264-74. doi: 10.1111/1346-8138.13219. PMID: 26945534

See all (45)

Recent clinical studies

Etiology

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Wilson disease.

Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896

Cutaneous paraneoplastic syndromes.

Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994

Arrhythmogenic cardiomyopathy.

Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C
Orphanet J Rare Dis 2016 Apr 2;11:33. doi: 10.1186/s13023-016-0407-1. PMID: 27038780 Free PMC Article

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (337)

Diagnosis

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

Spiny keratoderma.

Corral M, Paret C, Iglesias M, Amores E, Fernández MT, Salleras M
Dermatol Online J 2020 Sep 15;26(9) PMID: 33054945

Acquired palmoplantar keratoderma.

Patel S, Zirwas M, English JC 3rd
Am J Clin Dermatol 2007;8(1):1-11. doi: 10.2165/00128071-200708010-00001. PMID: 17298101

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Acrokeratoelastoidosis.

Dyall-Smith D
Australas J Dermatol 1996 Nov;37(4):213-4. doi: 10.1111/j.1440-0960.1996.tb01058.x. PMID: 8961592

See all (805)

Therapy

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Wilson disease.

Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896

A Review on Pityriasis Rubra Pilaris.

Wang D, Chong VC, Chong WS, Oon HH
Am J Clin Dermatol 2018 Jun;19(3):377-390. doi: 10.1007/s40257-017-0338-1. PMID: 29302927

KID syndrome.

Abdollahi A, Hallaji Z, Esmaili N, Valikhani M, Barzegari M, Akhyani M, Toosi S, Miresmaili A
Dermatol Online J 2007 Oct 13;13(4):11. PMID: 18319008

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (391)

Prognosis

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

A Review on Pityriasis Rubra Pilaris.

Wang D, Chong VC, Chong WS, Oon HH
Am J Clin Dermatol 2018 Jun;19(3):377-390. doi: 10.1007/s40257-017-0338-1. PMID: 29302927

Cutaneous paraneoplasia.

Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730

Palmoplantar keratodermas.

Itin PH, Fistarol SK
Clin Dermatol 2005 Jan-Feb;23(1):15-22. doi: 10.1016/j.clindermatol.2004.09.005. PMID: 15708285

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (257)

Clinical prediction guides

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Olmsted syndrome: clinical, molecular and therapeutic aspects.

Duchatelet S, Hovnanian A
Orphanet J Rare Dis 2015 Mar 17;10:33. doi: 10.1186/s13023-015-0246-5. PMID: 25886873 Free PMC Article

Keratins and skin disease.

Knöbel M, O'Toole EA, Smith FJ
Cell Tissue Res 2015 Jun;360(3):583-9. Epub 2015 Jan 27 doi: 10.1007/s00441-014-2105-4. PMID: 25620412

KID syndrome.

Abdollahi A, Hallaji Z, Esmaili N, Valikhani M, Barzegari M, Akhyani M, Toosi S, Miresmaili A
Dermatol Online J 2007 Oct 13;13(4):11. PMID: 18319008

See all (346)

Recent systematic reviews

Is punctate palmoplantar keratoderma type 1 associated with malignancy? A systematic review of the literature.

Gram SB, Bjerrelund J, Jelsig AM, Bygum A, Leboeuf-Yde C, Ousager LB
Orphanet J Rare Dis 2023 Sep 13;18(1):290. doi: 10.1186/s13023-023-02862-8. PMID: 37705065 Free PMC Article

Acitretin-induced periungual pyogenic granulomas and review.

Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Loricrin downregulation and epithelial-related disorders: a systematic review.

Catunda R, Rekhi U, Clark D, Levin L, Febbraio M
J Dtsch Dermatol Ges 2019 Dec;17(12):1227-1238. Epub 2019 Dec 17 doi: 10.1111/ddg.14001. PMID: 31846220

Combination of palmoplantar keratoderma and hair shaft anomalies, the warning signal of severe arrhythmogenic cardiomyopathy: a systematic review on genetic desmosomal diseases.

Polivka L, Bodemer C, Hadj-Rabia S
J Med Genet 2016 May;53(5):289-95. Epub 2015 Sep 23 doi: 10.1136/jmedgenet-2015-103403. PMID: 26399581

See all (9)

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Keratoderma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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