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Multidrug-resistant tuberculosis

MedGen UID:
60163
Concept ID:
C0206526
Disease or Syndrome
Synonyms: MDR Tuberculosis; Multi-Drug Resistant Tuberculosis; Multidrug-Resistant Tuberculosis; Tuberculosis, MDR; Tuberculosis, Multi Drug Resistant; Tuberculosis, Multi-Drug Resistant; Tuberculosis, Multidrug Resistant; Tuberculosis, Multidrug-Resistant
SNOMED CT: Multidrug resistant tuberculosis (423092005)
 
Monarch Initiative: MONDO:0005861

Definition

Tuberculosis disease that is caused by a multidrug-resistant strain of Mycobacterium tuberculosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultidrug-resistant tuberculosis

Professional guidelines

PubMed

Nair A, Greeny A, Nandan A, Sah RK, Jose A, Dyawanapelly S, Junnuthula V, K V A, Sadanandan P
J Nanobiotechnology 2023 Nov 9;21(1):414. doi: 10.1186/s12951-023-02156-y. PMID: 37946240Free PMC Article
Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J
Dtsch Arztebl Int 2019 Oct 25;116(43):729-735. doi: 10.3238/arztebl.2019.0729. PMID: 31755407
Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR Jr
Lancet 2019 Sep 14;394(10202):953-966. doi: 10.1016/S0140-6736(19)31882-3. PMID: 31526739Free PMC Article

Recent clinical studies

Etiology

Chopra KK, Matta S, Arora VK
Indian J Tuberc 2022;69 Suppl 2:S202-S204. Epub 2022 Oct 26 doi: 10.1016/j.ijtb.2022.10.022. PMID: 36400509
Morales Pérez C, Gomez-Pastrana D, Aragón Fernández C, Pérez Escolano E
Arch Bronconeumol (Engl Ed) 2019 Jul;55(7):388-390. Epub 2019 Jan 8 doi: 10.1016/j.arbres.2018.10.014. PMID: 30635203
Pradipta IS, Forsman LD, Bruchfeld J, Hak E, Alffenaar JW
J Infect 2018 Dec;77(6):469-478. Epub 2018 Oct 16 doi: 10.1016/j.jinf.2018.10.004. PMID: 30339803
Gruber K
Lancet Respir Med 2016 Nov;4(11):870-871. doi: 10.1016/S2213-2600(16)30335-6. PMID: 27799128
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508

Diagnosis

Gamell A, Latre C, López-Ramos MG, Noguera-Julian A
An Pediatr (Engl Ed) 2023 Aug;99(2):150-151. Epub 2023 Jun 22 doi: 10.1016/j.anpede.2023.01.016. PMID: 37355456
Hui SYA, Lao TT
Best Pract Res Clin Obstet Gynaecol 2022 Dec;85(Pt A):34-44. Epub 2022 Jul 31 doi: 10.1016/j.bpobgyn.2022.07.006. PMID: 36002371Free PMC Article
Bessis S, Matt M
Med Mal Infect 2019;49 Suppl 1:S10-S16. doi: 10.1016/S0399-077X(19)30802-9. PMID: 31542072
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508
Jacobs RF
Clin Infect Dis 1994 Jul;19(1):1-8; quiz 9-10. doi: 10.1093/clinids/19.1.1. PMID: 7948509

Therapy

Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR Jr, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L; Study group on Mycobacteria (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Clin Microbiol Infect 2024 Sep;30(9):1107-1114. Epub 2023 Jul 22 doi: 10.1016/j.cmi.2023.07.013. PMID: 37482332
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2015 Aug;80(2):182-4. Epub 2015 Jul 2 doi: 10.1111/bcp.12613. PMID: 25702772Free PMC Article

Prognosis

Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, Kampmann B, Graham SM, Dodd PJ, Houben RM, Denholm JT, Sawyer SM, Kranzer K
Lancet Child Adolesc Health 2020 Jan;4(1):68-79. Epub 2019 Nov 18 doi: 10.1016/S2352-4642(19)30337-2. PMID: 31753806Free PMC Article
Kanchar A, Swaminathan S
Indian J Pediatr 2019 Aug;86(8):703-706. Epub 2019 Jun 25 doi: 10.1007/s12098-019-02989-2. PMID: 31240568
Kritski A, Andrade KB, Galliez RM, Maciel ELN, Cordeiro-Santos M, Miranda SS, Villa TS, Ruffino Netto A, Arakaki-Sanchéz D, Croda J
Rev Soc Bras Med Trop 2018 Jan-Feb;51(1):2-6. doi: 10.1590/0037-8682-0349-2017. PMID: 29513837
Gruber K
Lancet Respir Med 2016 Nov;4(11):870-871. doi: 10.1016/S2213-2600(16)30335-6. PMID: 27799128
Houben RM, Dodd PJ
PLoS Med 2016 Oct;13(10):e1002152. Epub 2016 Oct 25 doi: 10.1371/journal.pmed.1002152. PMID: 27780211Free PMC Article

Clinical prediction guides

Ivanova O, Hoffmann VS, Lange C, Hoelscher M, Rachow A
Eur Respir Rev 2023 Jun 30;32(168) Epub 2023 Apr 19 doi: 10.1183/16000617.0221-2022. PMID: 37076175Free PMC Article
Jeong HE, Bea S, Kim JH, Jang SH, Son H, Shin JY
J Microbiol Immunol Infect 2023 Apr;56(2):424-428. Epub 2022 Sep 7 doi: 10.1016/j.jmii.2022.08.014. PMID: 36115791
Günther G, Ruswa N, Keller PM
Curr Opin Pulm Med 2022 May 1;28(3):211-217. Epub 2022 Feb 25 doi: 10.1097/MCP.0000000000000866. PMID: 35220372Free PMC Article
Nahid P, Mase SR, Migliori GB, Sotgiu G, Bothamley GH, Brozek JL, Cattamanchi A, Cegielski JP, Chen L, Daley CL, Dalton TL, Duarte R, Fregonese F, Horsburgh CR Jr, Ahmad Khan F, Kheir F, Lan Z, Lardizabal A, Lauzardo M, Mangan JM, Marks SM, McKenna L, Menzies D, Mitnick CD, Nilsen DM, Parvez F, Peloquin CA, Raftery A, Schaaf HS, Shah NS, Starke JR, Wilson JW, Wortham JM, Chorba T, Seaworth B
Am J Respir Crit Care Med 2019 Nov 15;200(10):e93-e142. doi: 10.1164/rccm.201909-1874ST. PMID: 31729908Free PMC Article
Gröschel MI, Walker TM, van der Werf TS, Lange C, Niemann S, Merker M
PLoS Pathog 2018 Oct;14(10):e1007297. Epub 2018 Oct 18 doi: 10.1371/journal.ppat.1007297. PMID: 30335850Free PMC Article

Recent systematic reviews

Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M
Infect Dis Poverty 2023 May 25;12(1):57. doi: 10.1186/s40249-023-01107-x. PMID: 37231463Free PMC Article
Ivanova O, Hoffmann VS, Lange C, Hoelscher M, Rachow A
Eur Respir Rev 2023 Jun 30;32(168) Epub 2023 Apr 19 doi: 10.1183/16000617.0221-2022. PMID: 37076175Free PMC Article
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Sultana ZZ, Hoque FU, Beyene J, Akhlak-Ul-Islam M, Khan MHR, Ahmed S, Hawlader DH, Hossain A
BMC Infect Dis 2021 Jan 11;21(1):51. doi: 10.1186/s12879-020-05749-2. PMID: 33430786Free PMC Article
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856

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