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Esthesioneuroblastoma

MedGen UID:
60217
•Concept ID:
C0206717
•
Neoplastic Process
Synonym: Olfactory esthesioneuroblastoma
SNOMED CT: Esthesioneuroepithelioma (68614005); Olfactory neuroepithelioma (68614005); Esthesioneuroblastoma (76060004); Olfactory neuroblastoma (76060004); Asthesioneuroblastoma (76060004); Olfactory neuroblastoma (422886007); Esthesioneuroblastoma (422886007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030068
Monarch Initiative: MONDO:0016029
Orphanet: ORPHA1957

Definition

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. [from HPO]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589

Recent clinical studies

Etiology

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Contemporary management of esthesioneuroblastoma.
Schwartz JS, Palmer JN, Adappa ND
Curr Opin Otolaryngol Head Neck Surg 2016 Feb;24(1):63-9. doi: 10.1097/MOO.0000000000000220. PMID: 26575517
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598
Esthesioneuroblastoma.
Shah JP, Feghali J
Am J Surg 1981 Oct;142(4):456-8. doi: 10.1016/0002-9610(81)90374-3. PMID: 7283046

Diagnosis

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Olfactory neuroblastoma.
Thompson LD
Head Neck Pathol 2009 Sep;3(3):252-9. Epub 2009 Jul 16 doi: 10.1007/s12105-009-0125-2. PMID: 20596981Free PMC Article
Esthesioneuroblastoma.
Shah JP, Feghali J
Am J Surg 1981 Oct;142(4):456-8. doi: 10.1016/0002-9610(81)90374-3. PMID: 7283046

Therapy

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
An unusual manifestation of olfactory neuroblastoma.
Batacchi Z, Andeen NK, Trikudanathan S
BMJ Case Rep 2018 Mar 13;2018 doi: 10.1136/bcr-2017-221661. PMID: 29535093Free PMC Article
Evidence-based practice: endoscopic skull base resection for malignancy.
Rawal RB, Gore MR, Harvey RJ, Zanation AM
Otolaryngol Clin North Am 2012 Oct;45(5):1127-42. doi: 10.1016/j.otc.2012.06.013. PMID: 22980689
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598

Prognosis

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
Olfactory Neuroblastoma.
Veyrat M, Vérillaud B, Fiaux-Camous D, Froelich S, Bresson D, Nicolai P, Herman P
Adv Otorhinolaryngol 2020;84:154-167. Epub 2020 Jul 30 doi: 10.1159/000457935. PMID: 32731231
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598
Paranasal sinus cancer.
Bridger GP, Mendelsohn MS, Baldwin M, Smee R
Aust N Z J Surg 1991 Apr;61(4):290-4. doi: 10.1111/j.1445-2197.1991.tb00214.x. PMID: 2018438
Olfactory esthesioneuroblastoma.
Jensen KJ, Elbrond O, Lund C
J Laryngol Otol 1976 Nov;90(11):1007-13. doi: 10.1017/s0022215100083043. PMID: 1003025

Clinical prediction guides

Role of induction chemotherapy in advanced-stage olfactory neuroblastoma.
Cho SW, Keam B, Lee KW, Kim JW, Han DH, Kim HJ, Kim JW, Kim DY, Rhee CS, Bae YJ, Kim JH, Eom KY, Wu HG, Kim YH, Kim CY, Paek SH, Kim H, Won TB
Int Forum Allergy Rhinol 2024 Dec;14(12):1882-1891. Epub 2024 Aug 20 doi: 10.1002/alr.23428. PMID: 39162101
Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
A rare presentation of esthesioneuroblastoma: a case report and review of the literature.
Sghier AB, Samba S, Bouabid M, Berhili S, Moukhlissi M, Mezouar L
Pan Afr Med J 2023;46:111. Epub 2023 Dec 21 doi: 10.11604/pamj.2023.46.111.42205. PMID: 38465014Free PMC Article
SSTR2 Expression in Olfactory Neuroblastoma: Clinical and Therapeutic Implications.
Cracolici V, Wang EW, Gardner PA, Snyderman C, Gargano SM, Chiosea S, Singhi AD, Seethala RR
Head Neck Pathol 2021 Dec;15(4):1185-1191. Epub 2021 Apr 30 doi: 10.1007/s12105-021-01329-1. PMID: 33929681Free PMC Article
Esthesioneuroblastoma: the Johns Hopkins experience.
Resto VA, Eisele DW, Forastiere A, Zahurak M, Lee DJ, Westra WH
Head Neck 2000 Sep;22(6):550-8. doi: 10.1002/1097-0347(200009)22:6<550::aid-hed2>3.0.co;2-0. PMID: 10941155

Recent systematic reviews

Immunohistochemical Profiling and Staging in Esthesioneuroblastoma: A Single-Center Cohort Study and Systematic Review.
Henson JC, Cutler CC, Cole KL, Lucke-Wold B, Khan M, Alt JA, Karsy M
World Neurosurg 2023 Feb;170:e652-e665. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.094. PMID: 36435382
Elective neck irradiation in the management of esthesioneuroblastoma: a systematic review and meta-analysis.
De Virgilio A, Costantino A, Sebastiani D, Russo E, Franzese C, Mercante G, Scorsetti M, Spriano G
Rhinology 2021 Oct 1;59(5):433-440. doi: 10.4193/Rhin21.139. PMID: 34254061
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676
Long-term carcinologic results of advanced esthesioneuroblastoma: a systematic review.
De Bonnecaze G, Lepage B, Rimmer J, Al Hawat A, Vairel B, Serrano E, Chaput B, Vergez S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):21-6. Epub 2014 Oct 17 doi: 10.1007/s00405-014-3320-z. PMID: 25323151
Endoscopic endonasal compared with anterior craniofacial and combined cranionasal resection of esthesioneuroblastomas.
Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH
World Neurosurg 2013 Jul-Aug;80(1-2):148-59. Epub 2012 Dec 7 doi: 10.1016/j.wneu.2012.12.003. PMID: 23228365

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