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Frailty

MedGen UID:
603303
Concept ID:
C0424594
Finding
Synonyms: Frailness; Frailties
SNOMED CT: Frailty (248279007)
 
HPO: HP:0033675

Definition

A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrailty

Professional guidelines

PubMed

Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD
Lancet 2019 Oct 12;394(10206):1376-1386. doi: 10.1016/S0140-6736(19)31785-4. PMID: 31609229
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article

Recent clinical studies

Etiology

Cohen CI, Benyaminov R, Rahman M, Ngu D, Reinhardt M
Med Clin North Am 2023 Jan;107(1):183-197. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.04.006. PMID: 36402498
Lee H, Lee E, Jang IY
J Korean Med Sci 2020 Jan 20;35(3):e16. doi: 10.3346/jkms.2020.35.e16. PMID: 31950775Free PMC Article
Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP
Lancet 2019 Oct 12;394(10206):1365-1375. doi: 10.1016/S0140-6736(19)31786-6. PMID: 31609228
Walston J, Buta B, Xue QL
Clin Geriatr Med 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMID: 29129215Free PMC Article

Diagnosis

Cohen CI, Benyaminov R, Rahman M, Ngu D, Reinhardt M
Med Clin North Am 2023 Jan;107(1):183-197. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.04.006. PMID: 36402498
Sugimoto T, Arai H, Sakurai T
Geriatr Gerontol Int 2022 Feb;22(2):99-109. Epub 2021 Dec 9 doi: 10.1111/ggi.14322. PMID: 34882939
Proietti M, Cesari M
Adv Exp Med Biol 2020;1216:1-7. doi: 10.1007/978-3-030-33330-0_1. PMID: 31894541
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD
Lancet 2019 Oct 12;394(10206):1376-1386. doi: 10.1016/S0140-6736(19)31785-4. PMID: 31609229
Walston J, Buta B, Xue QL
Clin Geriatr Med 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMID: 29129215Free PMC Article

Therapy

Hung A, Kim YH, Pavon JM
BMJ 2024 May 7;385:e074892. doi: 10.1136/bmj-2023-074892. PMID: 38719530
Zhang Y, Zhou JJ, Zhang XM, Liu JT, Li MR, Liang JY, Gao YL
Int J Geriatr Psychiatry 2023 Sep;38(9):e5994. doi: 10.1002/gps.5994. PMID: 37655500
Huang CY, Mayer PK, Wu MY, Liu DH, Wu PC, Yen HR
Ageing Res Rev 2022 Dec;82:101747. Epub 2022 Oct 9 doi: 10.1016/j.arr.2022.101747. PMID: 36223875
de Labra C, Guimaraes-Pinheiro C, Maseda A, Lorenzo T, Millán-Calenti JC
BMC Geriatr 2015 Dec 2;15:154. doi: 10.1186/s12877-015-0155-4. PMID: 26626157Free PMC Article
Landi F, Marzetti E, Martone AM, Bernabei R, Onder G
Curr Opin Clin Nutr Metab Care 2014 Jan;17(1):25-31. doi: 10.1097/MCO.0000000000000018. PMID: 24310054

Prognosis

Jayanama K, Theou O, Godin J, Cahill L, Shivappa N, Hébert JR, Wirth MD, Park YM, Fung TT, Rockwood K
BMC Med 2021 Mar 16;19(1):64. doi: 10.1186/s12916-021-01918-5. PMID: 33722232Free PMC Article
Ludman PF
Heart 2019 Mar;105(Suppl 2):s2-s5. doi: 10.1136/heartjnl-2018-313510. PMID: 30846517
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS
Lancet Public Health 2018 Jul;3(7):e323-e332. Epub 2018 Jun 14 doi: 10.1016/S2468-2667(18)30091-4. PMID: 29908859Free PMC Article
Afilalo J, Lauck S, Kim DH, Lefèvre T, Piazza N, Lachapelle K, Martucci G, Lamy A, Labinaz M, Peterson MD, Arora RC, Noiseux N, Rassi A, Palacios IF, Généreux P, Lindman BR, Asgar AW, Kim CA, Trnkus A, Morais JA, Langlois Y, Rudski LG, Morin JF, Popma JJ, Webb JG, Perrault LP
J Am Coll Cardiol 2017 Aug 8;70(6):689-700. Epub 2017 Jul 7 doi: 10.1016/j.jacc.2017.06.024. PMID: 28693934

Clinical prediction guides

Kojima G, Iliffe S, Walters K
Age Ageing 2018 Mar 1;47(2):193-200. doi: 10.1093/ageing/afx162. PMID: 29040347
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S
Hepatology 2017 Aug;66(2):564-574. Epub 2017 Jun 28 doi: 10.1002/hep.29219. PMID: 28422306Free PMC Article
Vermeiren S, Vella-Azzopardi R, Beckwée D, Habbig AK, Scafoglieri A, Jansen B, Bautmans I; Gerontopole Brussels Study group
J Am Med Dir Assoc 2016 Dec 1;17(12):1163.e1-1163.e17. doi: 10.1016/j.jamda.2016.09.010. PMID: 27886869
Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, Young J
Ann Oncol 2015 Jun;26(6):1091-1101. Epub 2014 Nov 17 doi: 10.1093/annonc/mdu540. PMID: 25403592
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A
CMAJ 2005 Aug 30;173(5):489-95. doi: 10.1503/cmaj.050051. PMID: 16129869Free PMC Article

Recent systematic reviews

Wang X, Hu J, Wu D
Medicine (Baltimore) 2022 Aug 26;101(34):e30169. doi: 10.1097/MD.0000000000030169. PMID: 36042657Free PMC Article
Picca A, Coelho-Junior HJ, Calvani R, Marzetti E, Vetrano DL
Ageing Res Rev 2022 Jan;73:101530. Epub 2021 Nov 25 doi: 10.1016/j.arr.2021.101530. PMID: 34839041
Dibello V, Zupo R, Sardone R, Lozupone M, Castellana F, Dibello A, Daniele A, De Pergola G, Bortone I, Lampignano L, Giannelli G, Panza F
Lancet Healthy Longev 2021 Aug;2(8):e507-e520. doi: 10.1016/S2666-7568(21)00143-4. PMID: 36098000
Veronese N, Custodero C, Cella A, Demurtas J, Zora S, Maggi S, Barbagallo M, Sabbà C, Ferrucci L, Pilotto A
Ageing Res Rev 2021 Dec;72:101498. Epub 2021 Oct 23 doi: 10.1016/j.arr.2021.101498. PMID: 34700009
Lin HS, Watts JN, Peel NM, Hubbard RE
BMC Geriatr 2016 Aug 31;16(1):157. doi: 10.1186/s12877-016-0329-8. PMID: 27580947Free PMC Article

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