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Klatskin tumor

MedGen UID:
61664
Concept ID:
C0206702
Neoplastic Process
Synonyms: Hilar Cholangiocarcinoma; Klatskin's tumor
SNOMED CT: Klatskin's tumor (6492006); Klatskin's tumor morphology (6492006); Klatskin tumor (253017000); Klatskin tumor (6492006); Klatskin's tumor (253017000); Hilar cholangiocarcinoma (253017000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0003345
Orphanet: ORPHA99978

Definition

Klatskin tumor is an extra-hepatic cholangiocarcinoma (CCA, see this term) arising in the junction of the main right or left hepatic ducts to form the common hepatic duct. [from ORDO]

Professional guidelines

PubMed

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M
Dig Endosc 2022 Sep;34(6):1147-1156. Epub 2022 Jun 2 doi: 10.1111/den.14317. PMID: 35377509
Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article

Recent clinical studies

Etiology

Patrono D, De Stefano N, Romagnoli R
Curr Opin Organ Transplant 2024 Aug 1;29(4):255-265. Epub 2024 May 8 doi: 10.1097/MOT.0000000000001149. PMID: 38716718
Moll CF, de Moura DTH, Ribeiro IB, Proença IM, do Monte Junior ES, Sánchez-Luna SA, Merchán MFS, Intriago JMV, Bernardo WM, de Moura EGH
Clinics (Sao Paulo) 2023;78:100163. Epub 2023 Jan 19 doi: 10.1016/j.clinsp.2022.100163. PMID: 36681067Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Costamagna G, Tringali A, Petruzziello L, Spada C
Can J Gastroenterol 2004 Jul;18(7):451-4. doi: 10.1155/2004/723989. PMID: 15229747

Diagnosis

Harrison JM, Visser BC
Surg Clin North Am 2024 Dec;104(6):1281-1293. Epub 2024 May 10 doi: 10.1016/j.suc.2024.04.003. PMID: 39448128
Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Khan AS, Dageforde LA
Surg Clin North Am 2019 Apr;99(2):315-335. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.12.004. PMID: 30846037
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article

Therapy

Smits J, Chau S, James S, Korenblik R, Tschögl M, Arntz P, Bednarsch J, Abreu de Carvalho L, Detry O, Erdmann J, Gruenberger T, Hermie L, Neumann U, Sandström P, Sutcliffe R, Denys A, Melloul E, Dewulf M, van der Leij C, van Dam RM; EuroLVD and DRAGON Trials Collaborative
HPB (Oxford) 2024 Dec;26(12):1458-1466. Epub 2024 Jul 16 doi: 10.1016/j.hpb.2024.07.407. PMID: 39277435
Patrono D, De Stefano N, Romagnoli R
Curr Opin Organ Transplant 2024 Aug 1;29(4):255-265. Epub 2024 May 8 doi: 10.1097/MOT.0000000000001149. PMID: 38716718
Moll CF, de Moura DTH, Ribeiro IB, Proença IM, do Monte Junior ES, Sánchez-Luna SA, Merchán MFS, Intriago JMV, Bernardo WM, de Moura EGH
Clinics (Sao Paulo) 2023;78:100163. Epub 2023 Jan 19 doi: 10.1016/j.clinsp.2022.100163. PMID: 36681067Free PMC Article
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article

Prognosis

Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Ernani L, Martino RB, Andraus W, Fernandes ESM, Mello FPT, Andrade R, Pimentel LS, Haddad LBP, Coelho FF, Herman P, D'Albuquerque LAC
Arq Bras Cir Dig 2022;34(3):e1618. Epub 2022 Jan 5 doi: 10.1590/0102-672020210002e1618. PMID: 35019130Free PMC Article
Anderson B, Doyle MBM
Surg Oncol Clin N Am 2019 Oct;28(4):601-617. Epub 2019 Aug 2 doi: 10.1016/j.soc.2019.06.003. PMID: 31472908
Brown KM, Geller DA
Surg Clin North Am 2014 Apr;94(2):311-23. Epub 2014 Feb 4 doi: 10.1016/j.suc.2013.12.003. PMID: 24679423

Clinical prediction guides

Smits J, Chau S, James S, Korenblik R, Tschögl M, Arntz P, Bednarsch J, Abreu de Carvalho L, Detry O, Erdmann J, Gruenberger T, Hermie L, Neumann U, Sandström P, Sutcliffe R, Denys A, Melloul E, Dewulf M, van der Leij C, van Dam RM; EuroLVD and DRAGON Trials Collaborative
HPB (Oxford) 2024 Dec;26(12):1458-1466. Epub 2024 Jul 16 doi: 10.1016/j.hpb.2024.07.407. PMID: 39277435
Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Breuer E, Mueller M, Doyle MB, Yang L, Darwish Murad S, Anwar IJ, Merani S, Limkemann A, Jeddou H, Kim SC, López-López V, Nassar A, Hoogwater FJH, Vibert E, De Oliveira ML, Cherqui D, Porte RJ, Magliocca JF, Fischer L, Fondevila C, Zieniewicz K, Ramírez P, Foley DP, Boudjema K, Schenk AD, Langnas AN, Knechtle S, Polak WG, Taner CB, Chapman WC, Rosen CB, Gores GJ, Dutkowski P, Heimbach JK, Clavien PA
Ann Surg 2022 Nov 1;276(5):846-853. Epub 2022 Jul 27 doi: 10.1097/SLA.0000000000005641. PMID: 35894433Free PMC Article
Celotti A, Solaini L, Montori G, Coccolini F, Tognali D, Baiocchi G
Eur J Surg Oncol 2017 Sep;43(9):1628-1635. Epub 2017 Apr 18 doi: 10.1016/j.ejso.2017.04.001. PMID: 28477976
Hartl J, Werner T, Schramm C
Gastroenterology 2014 Jun;146(7):e3-4. Epub 2014 Apr 26 doi: 10.1053/j.gastro.2014.01.011. PMID: 24780210

Recent systematic reviews

Wang D, Xiong F, Wu G, Wang Q, Chen J, Liu W, Wang B, Chen Y
Int J Surg 2024 Jan 1;110(1):385-394. doi: 10.1097/JS9.0000000000000795. PMID: 37738006Free PMC Article
Moll CF, de Moura DTH, Ribeiro IB, Proença IM, do Monte Junior ES, Sánchez-Luna SA, Merchán MFS, Intriago JMV, Bernardo WM, de Moura EGH
Clinics (Sao Paulo) 2023;78:100163. Epub 2023 Jan 19 doi: 10.1016/j.clinsp.2022.100163. PMID: 36681067Free PMC Article
Rahnemai-Azar AA, Abbasi A, Tsilimigras DI, Weber SM, Pawlik TM
J Gastrointest Surg 2020 Sep;24(9):2143-2149. Epub 2020 May 14 doi: 10.1007/s11605-020-04639-x. PMID: 32410178
Celotti A, Solaini L, Montori G, Coccolini F, Tognali D, Baiocchi G
Eur J Surg Oncol 2017 Sep;43(9):1628-1635. Epub 2017 Apr 18 doi: 10.1016/j.ejso.2017.04.001. PMID: 28477976
Moole H, Dharmapuri S, Duvvuri A, Dharmapuri S, Boddireddy R, Moole V, Yedama P, Bondalapati N, Uppu A, Yerasi C
Can J Gastroenterol Hepatol 2016;2016:4726078. Epub 2016 Aug 25 doi: 10.1155/2016/4726078. PMID: 27648439Free PMC Article

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