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Inverted papilloma

MedGen UID:: 61668
•Concept ID:: C0206721
•: Neoplastic Process

Synonyms:	Inverted Papilloma; Inverted Papillomas; Papilloma, Inverted; Papillomas, Inverted
SNOMED CT:	Benign inverted papilloma (104081000119103)

Monarch Initiative:	MONDO:0002537

Definition

An endophytic benign papillary epithelial neoplasm that results from the invagination and proliferation of epithelial cells in the underlying stroma. Representative examples are the inverted urothelial papilloma that arises from the urinary tract and inverted Schneiderian papilloma that arises from the nasal cavity or paranasal sinuses. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764

Clinical management of emerging sinonasal malignancies.

Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Sinonasal inverted papilloma: From diagnosis to treatment.

Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431

See all (33)

Recent clinical studies

Etiology

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies.

Viitasalo S, Ilmarinen T, Aaltonen LM, Hagström J, Hytönen M, Hammarén-Malmi S, Pietarinen P, Järvenpää P, Kinnari T, Geneid A, Lilja M
Laryngoscope 2023 Mar;133(3):506-511. Epub 2022 Apr 5 doi: 10.1002/lary.30128. PMID: 35383941

Long-term ambient air pollution exposure and risk of sinonasal inverted papilloma.

Mydlarz WK, London NR Jr, Biswal S, Ramanathan M Jr, Zhang Z
Int Forum Allergy Rhinol 2022 Sep;12(9):1200-1203. Epub 2022 Jan 25 doi: 10.1002/alr.22968. PMID: 34995005 Free PMC Article

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience.

Binz GHA, Soyka MB, Holzmann D, Meerwein CM
Head Neck 2021 Feb;43(2):630-638. Epub 2020 Oct 26 doi: 10.1002/hed.26523. PMID: 33103314

Sinonasal inverted papilloma: From diagnosis to treatment.

Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431

Inverted papilloma: The stubbornly persistent tumor of the sinonasal cavity.

Rotenberg BW
Am J Rhinol Allergy 2016 Mar-Apr;30(2):77-8. doi: 10.2500/ajra.2016.30.4309. PMID: 26980387 Free PMC Article

See all (591)

Diagnosis

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies.

Sinonasal inverted papilloma: From diagnosis to treatment.

Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431

Endoscopic management of sinonasal malignancy.

Batra PS, Citardi MJ
Otolaryngol Clin North Am 2006 Jun;39(3):619-37, x-xi. doi: 10.1016/j.otc.2006.01.012. PMID: 16757235

Inverted papilloma.

Brown JH, Chew FS
AJR Am J Roentgenol 1992 Aug;159(2):278. doi: 10.2214/ajr.159.2.1632339. PMID: 1632339

Inverted papilloma.

Wilson WR, Carrol ED, Bentkover SH, Schuknecht HF
Arch Otolaryngol 1980 Jan;106(1):54-61. doi: 10.1001/archotol.1980.00790250056012. PMID: 7352897

See all (575)

Therapy

Management of inverted papilloma: review.

Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032

EDITORIAL.

Kennedy DW
Int Forum Allergy Rhinol 2015 Dec;5(12):1083-4. doi: 10.1002/alr.21692. PMID: 26769189

Endoscopic resection of anterolateral maxillary sinus inverted papillomas.

Dean NR, Illing EA, Woodworth BA
Laryngoscope 2015 Apr;125(4):807-12. Epub 2014 Nov 21 doi: 10.1002/lary.25033. PMID: 25418039

Iatrogenic bilateral inverted papilloma: case report and literature review.

Rodriguez-Bruno K, Ali MJ, Wang SJ
J Otolaryngol 2007 Feb;36(1):72-5. doi: 10.2310/7070.2006.0068. PMID: 17376356

A study of functional endoscopic sinus surgery technique.

Haque MR, Hossain MM, Kundu SC, Kabir S, Alam S, Chowdhury WA, Faruque GM
Mymensingh Med J 2004 Jan;13(1):39-42. PMID: 14747784

See all (71)

Prognosis

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience.

Binz GHA, Soyka MB, Holzmann D, Meerwein CM
Head Neck 2021 Feb;43(2):630-638. Epub 2020 Oct 26 doi: 10.1002/hed.26523. PMID: 33103314

OSPs and ESPs and ISPs, Oh My! An Update on Sinonasal (Schneiderian) Papillomas.

Bishop JA
Head Neck Pathol 2017 Sep;11(3):269-277. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0799-9. PMID: 28321771 Free PMC Article

Primary sinonasal meningioma.

Mnejja M, Hammami B, Bougacha L, Kolsi N, Mnif H, Chakroun A, Charfeddine I, Boudawara T, Ghorbel A
Eur Ann Otorhinolaryngol Head Neck Dis 2012 Feb;129(1):47-50. Epub 2011 May 19 doi: 10.1016/j.anorl.2011.01.008. PMID: 21600866

Lacrimal sac mucus-secreting adenocarcinoma.

Bansal S, Khan AL, Hsuan J
Orbit 2008;27(3):199-201. doi: 10.1080/01676830701804180. PMID: 18569829

Inverted papilloma: incidence and late results of surgical treatment.

Outzen KE, Grøntveld A, Jørgensen K, Clausen PP, Ladefoged C
Rhinology 1996 Jun;34(2):114-8. PMID: 8876075

See all (368)

Clinical prediction guides

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience.

Binz GHA, Soyka MB, Holzmann D, Meerwein CM
Head Neck 2021 Feb;43(2):630-638. Epub 2020 Oct 26 doi: 10.1002/hed.26523. PMID: 33103314

OSPs and ESPs and ISPs, Oh My! An Update on Sinonasal (Schneiderian) Papillomas.

Bishop JA
Head Neck Pathol 2017 Sep;11(3):269-277. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0799-9. PMID: 28321771 Free PMC Article

Primary sinonasal meningioma.

Inverted papilloma.

Yu LH, Ho CY, Lin CZ
Zhonghua Yi Xue Za Zhi (Taipei) 2000 May;63(5):349-54. PMID: 10862443

Inverted papilloma: incidence and late results of surgical treatment.

Outzen KE, Grøntveld A, Jørgensen K, Clausen PP, Ladefoged C
Rhinology 1996 Jun;34(2):114-8. PMID: 8876075

See all (280)

Recent systematic reviews

A Systematic Review of Definitive Treatment for Inverted Papilloma Attachment Site and Associations With Recurrence.

Trent MS, Goshtasbi K, Hui L, Stuyt JAG, Adappa ND, Palmer JN, Kuan EC
Otolaryngol Head Neck Surg 2022 Sep;167(3):425-433. Epub 2021 Oct 12 doi: 10.1177/01945998211051975. PMID: 34637363

Association Between Human Papilloma Virus Infection and Malignant Sinonasal Inverted Papilloma.

Ding R, Sun Q, Wang Y
Laryngoscope 2021 Jun;131(6):1200-1205. Epub 2020 Oct 28 doi: 10.1002/lary.29125. PMID: 33111993

Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.

Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD
Am J Rhinol Allergy 2018 May;32(3):167-174. Epub 2018 Apr 12 doi: 10.1177/1945892418765004. PMID: 29649889

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.

Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463

Management of inverted papilloma: review.

Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032

See all (30)

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Inverted papilloma

Definition

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Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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