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Marek Disease

MedGen UID:
6219
•Concept ID:
C0024793
•
Neoplastic Process
Synonyms: Fowl Paralyses; Fowl Paralysis; Marek's Disease; Mareks Disease; Paralyses, Fowl; Paralysis, Fowl

Definition

A viral infection in chickens caused by the herpes virus. It is characterized by tissue lymphocytic infiltration, limb paralysis and development of tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMarek Disease

Professional guidelines

PubMed

A(2)BCD: a concise guide for asthma management.
Lommatzsch M, Brusselle GG, Levy ML, Canonica GW, Pavord ID, Schatz M, Virchow JC
Lancet Respir Med 2023 Jun;11(6):573-576. Epub 2023 Jan 27 doi: 10.1016/S2213-2600(22)00490-8. PMID: 36716752
International criteria for electrocardiographic interpretation in athletes: Consensus statement.
Drezner JA, Sharma S, Baggish A, Papadakis M, Wilson MG, Prutkin JM, Gerche A, Ackerman MJ, Borjesson M, Salerno JC, Asif IM, Owens DS, Chung EH, Emery MS, Froelicher VF, Heidbuchel H, Adamuz C, Asplund CA, Cohen G, Harmon KG, Marek JC, Molossi S, Niebauer J, Pelto HF, Perez MV, Riding NR, Saarel T, Schmied CM, Shipon DM, Stein R, Vetter VL, Pelliccia A, Corrado D
Br J Sports Med 2017 May;51(9):704-731. Epub 2017 Mar 3 doi: 10.1136/bjsports-2016-097331. PMID: 28258178
MDS clinical diagnostic criteria for Parkinson's disease.
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G
Mov Disord 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424. PMID: 26474316

Recent clinical studies

Etiology

FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes.
Davidson T, Kedmi M, Avigdor A, Komisar O, Chikman B, Lidar M, Goshen E, Tzila Zwas S, Ben-Haim S
Leuk Lymphoma 2018 Feb;59(2):348-356. Epub 2017 Jul 28 doi: 10.1080/10428194.2017.1352096. PMID: 28750592
INFECTIOUS DISEASES. Risk of 'leaky' vaccines debated.
Kupferschmidt K
Science 2015 Jul 31;349(6247):461-2. doi: 10.1126/science.349.6247.461. PMID: 26228119
gga-miR-26a targets NEK6 and suppresses Marek's disease lymphoma cell proliferation.
Li X, Lian L, Zhang D, Qu L, Yang N
Poult Sci 2014 May;93(5):1097-105. doi: 10.3382/ps.2013-03656. PMID: 24795301
Role of infections in the pathogenesis of atherosclerotic coronary artery disease: past, present and future.
Sinha N, Garg N
Indian Heart J 2000 Jan-Feb;52(1):79-85. PMID: 10820941
Lessons for atherosclerosis research from tuberculosis and peptic ulcer.
Sutter MC
CMAJ 1995 Mar 1;152(5):667-70. PMID: 7882229Free PMC Article

Diagnosis

Plexus and peripheral nerve metastasis.
Gwathmey KG
Handb Clin Neurol 2018;149:257-279. doi: 10.1016/B978-0-12-811161-1.00017-7. PMID: 29307357
(89) Zr-rituximab PET/CT to detect neurolymphomatosis.
de Jong A, Mous R, van Dongen GA, Hoekstra OS, Nievelstein RA, de Keizer B
Am J Hematol 2016 Jun;91(6):649-50. Epub 2016 Apr 13 doi: 10.1002/ajh.24328. PMID: 26872558
Neurolymphomatosis: MRI and (18) FDG-PET features.
Lim AT, Clucas D, Khoo C, Parameswaran BK, Lau E
J Med Imaging Radiat Oncol 2016 Feb;60(1):92-5. Epub 2015 May 13 doi: 10.1111/1754-9485.12321. PMID: 25974748
Fluorothymidine PET/CT in neurolymphomatosis.
Biswal CK, Mittal BR, Shukla J, Vatsa R, Bhattacharya A, Prabhakar S
Clin Nucl Med 2015 May;40(5):e290-2. doi: 10.1097/RLU.0000000000000632. PMID: 25546221
Observations of basic diagnostic profile patterns seen in some common disorders of backyard poultry species.
Speer BL
Vet Clin North Am Exot Anim Pract 1999 Sep;2(3):701-8, vii-viii. doi: 10.1016/s1094-9194(17)30117-2. PMID: 11229050

Therapy

INFECTIOUS DISEASES. Risk of 'leaky' vaccines debated.
Kupferschmidt K
Science 2015 Jul 31;349(6247):461-2. doi: 10.1126/science.349.6247.461. PMID: 26228119
Fowlpox virus as a recombinant vaccine vector for use in mammals and poultry.
Skinner MA, Laidlaw SM, Eldaghayes I, Kaiser P, Cottingham MG
Expert Rev Vaccines 2005 Feb;4(1):63-76. doi: 10.1586/14760584.4.1.63. PMID: 15757474
Clinical immunoadjuvant studies with tilorone, DEAA fluorene (RMI 11,002da), and Corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth.
Regelson W
Ann N Y Acad Sci 1976;277(00):269-87. doi: 10.1111/j.1749-6632.1976.tb41705.x. PMID: 187101
Antiviral chemotherapy and its significance to the poultry industry.
Gustafson DP
Am J Vet Res 1975 Apr;36(4 Pt 2):498-502. PMID: 1092216
Problems and potentials for human viral cancer vaccines.
Hilleman MR
Prev Med 1972 Aug;1(3):352-70. doi: 10.1016/0091-7435(72)90007-2. PMID: 4343587

Prognosis

Acute demyelinating neuropathy in a patient with neurolymphomatosis.
Mahmoud RA, Abrams CK
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222814. PMID: 29507018Free PMC Article
FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes.
Davidson T, Kedmi M, Avigdor A, Komisar O, Chikman B, Lidar M, Goshen E, Tzila Zwas S, Ben-Haim S
Leuk Lymphoma 2018 Feb;59(2):348-356. Epub 2017 Jul 28 doi: 10.1080/10428194.2017.1352096. PMID: 28750592
Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1.
Zhao C, Li X, Han B, You Z, Qu L, Liu C, Song J, Lian L, Yang N
Sci Rep 2017 Jun 26;7(1):4247. doi: 10.1038/s41598-017-04434-w. PMID: 28652615Free PMC Article
Marek's disease and new approaches to its control.
Zelník V
Acta Virol 1995 Feb;39(1):53-63. PMID: 7572471
Congenital contractural arachnodactyly.
Bjerkreim I, Skogland LB, Trygstad O
Acta Orthop Scand 1976 Jun;47(3):250-3. doi: 10.3109/17453677608991985. PMID: 986113

Clinical prediction guides

Purinergic signaling during Marek's disease in chickens.
Akbar H, Fasick JJ, Ponnuraj N, Jarosinski KW
Sci Rep 2023 Feb 4;13(1):2044. doi: 10.1038/s41598-023-29210-x. PMID: 36739336Free PMC Article
Observations of basic diagnostic profile patterns seen in some common disorders of backyard poultry species.
Speer BL
Vet Clin North Am Exot Anim Pract 1999 Sep;2(3):701-8, vii-viii. doi: 10.1016/s1094-9194(17)30117-2. PMID: 11229050
Cytomegalovirus and atherosclerosis.
Melnick JL, Adam E, Debakey ME
Eur Heart J 1993 Dec;14 Suppl K:30-8. PMID: 8131785
Clinical immunoadjuvant studies with tilorone, DEAA fluorene (RMI 11,002da), and Corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth.
Regelson W
Ann N Y Acad Sci 1976;277(00):269-87. doi: 10.1111/j.1749-6632.1976.tb41705.x. PMID: 187101
Are viruses important in carcinogenesis?
Rapp F, Buss ER
Am J Pathol 1974 Oct;77(1):85-102. PMID: 4374889Free PMC Article

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