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Middle lobe syndrome

MedGen UID:
6393
•Concept ID:
C0026069
•
Disease or Syndrome
Synonyms: Brock Syndrome; Brock's Syndrome; Brocks Syndrome; Middle Lobe Syndrome; Syndrome, Brock's; Syndromes, Middle Lobe
SNOMED CT: Middle lobe syndrome (28295001); Brock syndrome (28295001)
 
Monarch Initiative: MONDO:0005847

Definition

Atelectasis of the right middle pulmonary lobe, with chronic pneumonitis. (Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle lobe syndrome

Professional guidelines

PubMed

Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Gudbjartsson T, Gudmundsson G
Respiration 2012;84(1):80-6. Epub 2012 Mar 1 doi: 10.1159/000336238. PMID: 22377566
The so-called middle lobe syndrome. Diagnosis and results of treatment.
Bross W, Kaniowski T, Rogalski E, Kozuszek W
Bull Soc Int Chir 1970 May-Jun;29(3):182-5. PMID: 5487050
Diagnosis and results of treatment of middle lobe syndrome.
Bross W, Kaniowski T, Rogalski E, Kozuszek W
Pol Med Sci Hist Bull 1970 Jul;13(3):96-105. PMID: 4317528

Recent clinical studies

Etiology

Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Secretory hyperresponsiveness and pulmonary mucus hypersecretion.
Rubin BK, Priftis KN, Schmidt HJ, Henke MO
Chest 2014 Aug;146(2):496-507. doi: 10.1378/chest.13-2609. PMID: 25091755
Causes of recurrent pneumonia in children in a general hospital.
Hoving MF, Brand PL
J Paediatr Child Health 2013 Mar;49(3):E208-12. Epub 2013 Feb 26 doi: 10.1111/jpc.12114. PMID: 23438187
Middle lobe syndrome.
Gudmundsson G, Gross TJ
Am Fam Physician 1996 Jun;53(8):2547-50. PMID: 8644568
Middle lobe syndrome.
Wagner RB, Johnston MR
Ann Thorac Surg 1983 Jun;35(6):679-86. doi: 10.1016/s0003-4975(10)61085-5. PMID: 6344820

Diagnosis

Immune reconstitution inflammatory syndrome in non-HIV patients with tuberculosis. A case series.
Aggarwal D, Bhardwaj M, Kumar A, Saini V, Sawal N
Indian J Tuberc 2020 Jan;67(1):143-147. Epub 2019 Mar 6 doi: 10.1016/j.ijtb.2019.02.018. PMID: 32192610
Tuberculosis and Other Granulomatous Diseases of the Airway.
Santosham R, Deslauriers J
Thorac Surg Clin 2018 May;28(2):155-161. doi: 10.1016/j.thorsurg.2018.01.004. PMID: 29627049
Atelectasis in childhood.
Redding GJ
Pediatr Clin North Am 1984 Aug;31(4):891-905. doi: 10.1016/s0031-3955(16)34652-1. PMID: 6462803
Middle lobe syndrome.
Wagner RB, Johnston MR
Ann Thorac Surg 1983 Jun;35(6):679-86. doi: 10.1016/s0003-4975(10)61085-5. PMID: 6344820
Middle lobe syndrome.
Simecek C
Respiration 1970;27(1):100-3. doi: 10.1159/000192674. PMID: 4996247

Therapy

Immune reconstitution inflammatory syndrome in non-HIV patients with tuberculosis. A case series.
Aggarwal D, Bhardwaj M, Kumar A, Saini V, Sawal N
Indian J Tuberc 2020 Jan;67(1):143-147. Epub 2019 Mar 6 doi: 10.1016/j.ijtb.2019.02.018. PMID: 32192610
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Gudbjartsson T, Gudmundsson G
Respiration 2012;84(1):80-6. Epub 2012 Mar 1 doi: 10.1159/000336238. PMID: 22377566
Atelectasis in childhood.
Redding GJ
Pediatr Clin North Am 1984 Aug;31(4):891-905. doi: 10.1016/s0031-3955(16)34652-1. PMID: 6462803
Middle lobe syndrome and intractable asthma.
Caplin I, Haynes JT, Green M
J Asthma Res 1970 Dec;8(2):57-60. doi: 10.3109/02770907009108360. PMID: 5532652
Middle lobe disease.
McElvein RB, Mayo P
South Med J 1967 Oct;60(10):1029-32. doi: 10.1097/00007611-196710000-00002. PMID: 4863097

Prognosis

Case Report: Middle lobe syndrome: a rare presentation in eosinophilic granulomatosis with polyangiitis.
Maranini B, Guzzinati I, Casoni GL, Ballotta M, Lo Monaco A, Govoni M
Front Immunol 2023;14:1222431. Epub 2023 Aug 10 doi: 10.3389/fimmu.2023.1222431. PMID: 37638004Free PMC Article
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Intact endobronchial hydatid cyst: an unexpected bronchoscopic challenge.
Zamani A, Yosunkaya S
Asian Cardiovasc Thorac Ann 2018 Jan;26(1):60-62. Epub 2017 Apr 12 doi: 10.1177/0218492317705287. PMID: 28403624
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome.
Woźniak MS, Buchwald J, Stockdale I, Doniec Z
Adv Respir Med 2017;85(3):158-160. doi: 10.5603/ARM.2017.0027. PMID: 28667658
Right middle lobe torsion after right upper lobectomy in a patient with an undiagnosed middle lobe syndrome.
Gorospe L, Cabañero-Sánchez A, Muñoz-Molina GM, Ovejero-Díaz AP, Carvajal-Serrano P
Surgery 2017 Sep;162(3):688-689. Epub 2016 Oct 1 doi: 10.1016/j.surg.2016.08.037. PMID: 27707504

Clinical prediction guides

Middle lobe syndrome revealing Broncholithiasis: A Case Report.
Abid N, Loukil M, Gader N, Chaabane A, Bouzaidi K, Ghrairi H
Tunis Med 2023 Apr 5;101(4):460-462. PMID: 38372529Free PMC Article
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Intact endobronchial hydatid cyst: an unexpected bronchoscopic challenge.
Zamani A, Yosunkaya S
Asian Cardiovasc Thorac Ann 2018 Jan;26(1):60-62. Epub 2017 Apr 12 doi: 10.1177/0218492317705287. PMID: 28403624
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome.
Li J, Liu C, Zhao Y, Li C, Liu L
World J Surg 2017 Mar;41(3):780-784. doi: 10.1007/s00268-016-3777-6. PMID: 27807707Free PMC Article
Outcome after right middle lobe syndrome.
De Boeck K, Willems T, Van Gysel D, Corbeel L, Eeckels R
Chest 1995 Jul;108(1):150-2. doi: 10.1378/chest.108.1.150. PMID: 7606950

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