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Anhedonia

MedGen UID:
64230
•Concept ID:
C0178417
•
Mental or Behavioral Dysfunction
Synonym: Anhedonias
SNOMED CT: Diminished pleasure (247796005); Loss of pleasure (247796005); Loss of capacity for enjoyment (247796005); Anhedonia (28669007)
 
HPO: HP:0012154

Definition

Decreased ability to experience or feel joy or pleasure from any experience that is usually found to be pleasurable by the individual. This applies to any of the senses, e.g.,. taste, smell, and sound. Food may no longer be tasty, or a musical experience may no longer be enjoyable. Anhedonia also refers to an inability to feel pleasure related to activities that an affected individual previously derived pleasure from. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnhedonia

Professional guidelines

PubMed

Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials.
Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, Phan L, Cao B, McIntyre RS
Expert Opin Emerg Drugs 2021 Mar;26(1):63-74. Epub 2021 Mar 12 doi: 10.1080/14728214.2021.1898588. PMID: 33682569
Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation.
Siddiqi SH, Taylor SF, Cooke D, Pascual-Leone A, George MS, Fox MD
Am J Psychiatry 2020 May 1;177(5):435-446. Epub 2020 Mar 12 doi: 10.1176/appi.ajp.2019.19090915. PMID: 32160765Free PMC Article
Treatment for Anhedonia: A Neuroscience Driven Approach.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour HJ
Depress Anxiety 2016 Oct;33(10):927-938. doi: 10.1002/da.22490. PMID: 27699943

Recent clinical studies

Etiology

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.
Li H, Kawatake-Kuno A, Inaba H, Miyake Y, Itoh Y, Ueki T, Oishi N, Murai T, Suzuki T, Uchida S
Neuron 2024 Mar 6;112(5):786-804.e8. Epub 2024 Jan 15 doi: 10.1016/j.neuron.2023.12.004. PMID: 38228137
Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?
Pizzagalli DA
Am J Psychiatry 2022 Jul;179(7):458-469. doi: 10.1176/appi.ajp.20220423. PMID: 35775159Free PMC Article
Anhedonia and Suicide.
Auerbach RP, Pagliaccio D, Kirshenbaum JS
Curr Top Behav Neurosci 2022;58:443-464. doi: 10.1007/7854_2022_358. PMID: 35435645
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
Treatment for Anhedonia: A Neuroscience Driven Approach.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour HJ
Depress Anxiety 2016 Oct;33(10):927-938. doi: 10.1002/da.22490. PMID: 27699943

Diagnosis

Anhedonia in epilepsy.
Roberts-West L, Vivekananda U, Baxendale S
Epilepsy Behav 2023 Mar;140:108966. Epub 2022 Nov 25 doi: 10.1016/j.yebeh.2022.108966. PMID: 36443164
Schizophrenia: One Name, Many Different Manifestations.
Faden J, Citrome L
Med Clin North Am 2023 Jan;107(1):61-72. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.05.005. PMID: 36402500
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
Treatment for Anhedonia: A Neuroscience Driven Approach.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour HJ
Depress Anxiety 2016 Oct;33(10):927-938. doi: 10.1002/da.22490. PMID: 27699943
The neurobiology of anhedonia and other reward-related deficits.
Der-Avakian A, Markou A
Trends Neurosci 2012 Jan;35(1):68-77. Epub 2011 Dec 15 doi: 10.1016/j.tins.2011.11.005. PMID: 22177980Free PMC Article

Therapy

Ketamine in neuropsychiatric disorders: an update.
Johnston JN, Kadriu B, Kraus C, Henter ID, Zarate CA Jr
Neuropsychopharmacology 2024 Jan;49(1):23-40. Epub 2023 Jun 20 doi: 10.1038/s41386-023-01632-1. PMID: 37340091Free PMC Article
Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses.
Fountoulakis KN, Tohen M, Zarate CA Jr
Eur Neuropsychopharmacol 2022 Jan;54:100-115. doi: 10.1016/j.euroneuro.2021.10.003. PMID: 34980362Free PMC Article
Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation.
Siddiqi SH, Taylor SF, Cooke D, Pascual-Leone A, George MS, Fox MD
Am J Psychiatry 2020 May 1;177(5):435-446. Epub 2020 Mar 12 doi: 10.1176/appi.ajp.2019.19090915. PMID: 32160765Free PMC Article
Prognosis and improved outcomes in major depression: a review.
Kraus C, Kadriu B, Lanzenberger R, Zarate CA Jr, Kasper S
Transl Psychiatry 2019 Apr 3;9(1):127. doi: 10.1038/s41398-019-0460-3. PMID: 30944309Free PMC Article
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article

Prognosis

Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?
Pizzagalli DA
Am J Psychiatry 2022 Jul;179(7):458-469. doi: 10.1176/appi.ajp.20220423. PMID: 35775159Free PMC Article
Circuit-Targeted Neuromodulation for Anhedonia.
Siddiqi SH, Haddad N, Fox MD
Curr Top Behav Neurosci 2022;58:515-535. doi: 10.1007/7854_2022_350. PMID: 35604569
Treatment for Anhedonia: A Neuroscience Driven Approach.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour HJ
Depress Anxiety 2016 Oct;33(10):927-938. doi: 10.1002/da.22490. PMID: 27699943
Assessing anhedonia in depression: Potentials and pitfalls.
Rizvi SJ, Pizzagalli DA, Sproule BA, Kennedy SH
Neurosci Biobehav Rev 2016 Jun;65:21-35. Epub 2016 Mar 6 doi: 10.1016/j.neubiorev.2016.03.004. PMID: 26959336Free PMC Article
Development and validation of the Dimensional Anhedonia Rating Scale (DARS) in a community sample and individuals with major depression.
Rizvi SJ, Quilty LC, Sproule BA, Cyriac A, Michael Bagby R, Kennedy SH
Psychiatry Res 2015 Sep 30;229(1-2):109-19. Epub 2015 Jul 26 doi: 10.1016/j.psychres.2015.07.062. PMID: 26250147

Clinical prediction guides

Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?
Pizzagalli DA
Am J Psychiatry 2022 Jul;179(7):458-469. doi: 10.1176/appi.ajp.20220423. PMID: 35775159Free PMC Article
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
Treatment for Anhedonia: A Neuroscience Driven Approach.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour HJ
Depress Anxiety 2016 Oct;33(10):927-938. doi: 10.1002/da.22490. PMID: 27699943
Assessing anhedonia in depression: Potentials and pitfalls.
Rizvi SJ, Pizzagalli DA, Sproule BA, Kennedy SH
Neurosci Biobehav Rev 2016 Jun;65:21-35. Epub 2016 Mar 6 doi: 10.1016/j.neubiorev.2016.03.004. PMID: 26959336Free PMC Article
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Recent systematic reviews

Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses.
Fountoulakis KN, Tohen M, Zarate CA Jr
Eur Neuropsychopharmacol 2022 Jan;54:100-115. doi: 10.1016/j.euroneuro.2021.10.003. PMID: 34980362Free PMC Article
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis.
Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM, Rodrigues NB, Subramaniapillai M, Di Vincenzo JD, Cao B, Lin K, Mansur RB, Ho RC, Rosenblat JD, Miskowiak KW, Vinberg M, Maletic V, McIntyre RS
Brain Behav Immun 2022 Mar;101:93-135. Epub 2021 Dec 29 doi: 10.1016/j.bbi.2021.12.020. PMID: 34973396Free PMC Article
Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression: Systematic Review and Meta-analysis.
Levis B, Sun Y, He C, Wu Y, Krishnan A, Bhandari PM, Neupane D, Imran M, Brehaut E, Negeri Z, Fischer FH, Benedetti A, Thombs BD; Depression Screening Data (DEPRESSD) PHQ Collaboration, Che L, Levis A, Riehm K, Saadat N, Azar M, Rice D, Boruff J, Kloda L, Cuijpers P, Gilbody S, Ioannidis J, McMillan D, Patten S, Shrier I, Ziegelstein R, Moore A, Akena D, Amtmann D, Arroll B, Ayalon L, Baradaran H, Beraldi A, Bernstein C, Bhana A, Bombardier C, Buji RI, Butterworth P, Carter G, Chagas M, Chan J, Chan LF, Chibanda D, Cholera R, Clover K, Conway A, Conwell Y, Daray F, de Man-van Ginkel J, Delgadillo J, Diez-Quevedo C, Fann J, Field S, Fisher J, Fung D, Garman E, Gelaye B, Gholizadeh L, Gibson L, Goodyear-Smith F, Green E, Greeno C, Hall B, Hampel P, Hantsoo L, Haroz E, Harter M, Hegerl U, Hides L, Hobfoll S, Honikman S, Hudson M, Hyphantis T, Inagaki M, Ismail K, Jeon HJ, Jetté N, Khamseh M, Kiely K, Kohler S, Kohrt B, Kwan Y, Lamers F, Asunción Lara M, Levin-Aspenson H, Lino V, Liu SI, Lotrakul M, Loureiro S, Löwe B, Luitel N, Lund C, Marrie RA, Marsh L, Marx B, McGuire A, Mohd Sidik S, Munhoz T, Muramatsu K, Nakku J, Navarrete L, Osório F, Patel V, Pence B, Persoons P, Petersen I, Picardi A, Pugh S, Quinn T, Rancans E, Rathod S, Reuter K, Roch S, Rooney A, Rowe H, Santos I, Schram M, Shaaban J, Shinn E, Sidebottom A, Simning A, Spangenberg L, Stafford L, Sung S, Suzuki K, Swartz R, Tan PLL, Taylor-Rowan M, Tran T, Turner A, van der Feltz-Cornelis C, van Heyningen T, van Weert H, Wagner L, Li Wang J, White J, Winkley K, Wynter K, Yamada M, Zhi Zeng Q, Zhang Y
JAMA 2020 Jun 9;323(22):2290-2300. doi: 10.1001/jama.2020.6504. PMID: 32515813Free PMC Article
Physical Activity in Eating Disorders: A Systematic Review.
Rizk M, Mattar L, Kern L, Berthoz S, Duclos J, Viltart O, Godart N
Nutrients 2020 Jan 9;12(1) doi: 10.3390/nu12010183. PMID: 31936525Free PMC Article
The relationship between negative symptoms and depression in schizophrenia: a systematic review.
Krynicki CR, Upthegrove R, Deakin JFW, Barnes TRE
Acta Psychiatr Scand 2018 May;137(5):380-390. Epub 2018 Mar 13 doi: 10.1111/acps.12873. PMID: 29532909

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