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Subependymal glioma

MedGen UID:
64637
Concept ID:
C0206725
Neoplastic Process
Synonym: Subependymoma
SNOMED CT: Mixed subependymoma-ependymoma (4553004); Subependymal glioma (4553004); Subependymoma (4553004); Subependymal astrocytoma (4553004)
 
Monarch Initiative: MONDO:0007667
OMIM®: 137800
Orphanet: ORPHA251639

Definition

Subependymoma is a rare and slow growing type of ependymoma (see this term), often presenting in middle-aged adults, found more commonly in men than in women, usually located in the fourth and lateral ventricles and manifesting with variable symptoms including headache, nausea, and loss of balance. In some cases it can be asymptomatic. It is usually associated with a better prognosis than other forms of ependymoma. [from ORDO]

Professional guidelines

PubMed

Wirsching HG, Weller M
Curr Treat Options Oncol 2016 Oct;17(10):51. doi: 10.1007/s11864-016-0430-4. PMID: 27501915
Wu J, Armstrong TS, Gilbert MR
Neuro Oncol 2016 Jul;18(7):902-13. Epub 2016 Mar 28 doi: 10.1093/neuonc/now016. PMID: 27022130Free PMC Article
Pusateri A, Margo CE
Arch Pathol Lab Med 2014 Sep;138(9):1250-4. doi: 10.5858/arpa.2013-0448-RS. PMID: 25171711

Recent clinical studies

Etiology

Haider AS, El Ahmadieh TY, Haider M, Hatanpaa KJ, Pinho MC, Mickey BE, Sawaya R, Fuller GN, Schomer DF, Gule-Monroe M
Neuroradiology 2022 Sep;64(9):1795-1800. Epub 2022 Apr 15 doi: 10.1007/s00234-022-02944-7. PMID: 35426054Free PMC Article
Zhang Q, Xie SN, Wang K, Wang L, Du J, Guo TX, Jia W, Jia GJ, Zhang LW, Zhang JT, Wu Z
World Neurosurg 2018 Jun;114:e647-e653. Epub 2018 Mar 14 doi: 10.1016/j.wneu.2018.03.045. PMID: 29548959
Wu J, Armstrong TS, Gilbert MR
Neuro Oncol 2016 Jul;18(7):902-13. Epub 2016 Mar 28 doi: 10.1093/neuonc/now016. PMID: 27022130Free PMC Article
Wu Z, Iwanami A, Yasuda A, Mikami S, Toyama Y, Nakamura M
J Orthop Sci 2015 Sep;20(5):927-34. Epub 2014 May 20 doi: 10.1007/s00776-014-0585-4. PMID: 24842008
Waldron JS, Tihan T
Neurosurg Clin N Am 2003 Oct;14(4):469-82. doi: 10.1016/s1042-3680(03)00060-3. PMID: 15024796

Diagnosis

Chan DL, Calder T, Lawson JA, Mowat D, Kennedy SE
Rev Neurosci 2018 Mar 28;29(3):295-301. doi: 10.1515/revneuro-2017-0027. PMID: 29211682
Kim Y, Lee SY, Yi KS, Cha SH, Gang MH, Cho BS, Lee YM
Korean J Radiol 2014 Jan-Feb;15(1):151-5. Epub 2014 Jan 8 doi: 10.3348/kjr.2014.15.1.151. PMID: 24497806Free PMC Article
Kumar R, Sarkari A, Kakkar A
Neurol India 2012 Nov-Dec;60(6):684-5. doi: 10.4103/0028-3886.105228. PMID: 23287356
Waldron JS, Tihan T
Neurosurg Clin N Am 2003 Oct;14(4):469-82. doi: 10.1016/s1042-3680(03)00060-3. PMID: 15024796
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Therapy

Spiegel DR, Teixeira MN, Tracz JA, Colangelo TJ
Prim Care Companion CNS Disord 2023 Nov 7;25(6) doi: 10.4088/PCC.23cr03524. PMID: 37976231
Soleiman HA, Ironside J, Kealey S, Demetriades AK
Neurosurg Rev 2020 Aug;43(4):1047-1053. Epub 2019 Jun 18 doi: 10.1007/s10143-019-01128-x. PMID: 31214945
Varma A, Giraldi D, Mills S, Brodbelt AR, Jenkinson MD
Acta Neurochir (Wien) 2018 Sep;160(9):1793-1799. Epub 2018 Jun 18 doi: 10.1007/s00701-018-3570-4. PMID: 29915887Free PMC Article
Moavero R, Carai A, Mastronuzzi A, Marciano S, Graziola F, Vigevano F, Curatolo P
Pediatr Neurol 2017 Mar;68:59-63. Epub 2017 Jan 3 doi: 10.1016/j.pediatrneurol.2016.11.003. PMID: 28162859
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Prognosis

Zhang Q, Xie SN, Wang K, Wang L, Du J, Guo TX, Jia W, Jia GJ, Zhang LW, Zhang JT, Wu Z
World Neurosurg 2018 Jun;114:e647-e653. Epub 2018 Mar 14 doi: 10.1016/j.wneu.2018.03.045. PMID: 29548959
Fischer SB, Attenhofer M, Gultekin SH, Ross DA, Heinimann K
J Neurooncol 2017 Aug;134(1):133-138. Epub 2017 May 20 doi: 10.1007/s11060-017-2496-7. PMID: 28528424
Wu Z, Iwanami A, Yasuda A, Mikami S, Toyama Y, Nakamura M
J Orthop Sci 2015 Sep;20(5):927-34. Epub 2014 May 20 doi: 10.1007/s00776-014-0585-4. PMID: 24842008
Rath TJ, Sundgren PC, Brahma B, Lieberman AP, Chandler WF, Gebarski SS
Neuroradiology 2005 Mar;47(3):183-8. Epub 2005 Feb 9 doi: 10.1007/s00234-005-1342-3. PMID: 15702322
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Clinical prediction guides

Bashir HH, Aziz HF, Shamim MS
J Pak Med Assoc 2023 Sep;73(9):1919-1920. doi: 10.47391/JPMA.23-66. PMID: 37817716
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Varma A, Giraldi D, Mills S, Brodbelt AR, Jenkinson MD
Acta Neurochir (Wien) 2018 Sep;160(9):1793-1799. Epub 2018 Jun 18 doi: 10.1007/s00701-018-3570-4. PMID: 29915887Free PMC Article
Fischer SB, Attenhofer M, Gultekin SH, Ross DA, Heinimann K
J Neurooncol 2017 Aug;134(1):133-138. Epub 2017 May 20 doi: 10.1007/s11060-017-2496-7. PMID: 28528424
Iwasaki M, Hida K, Aoyama T, Houkin K
Eur Spine J 2013 May;22 Suppl 3(Suppl 3):S317-20. Epub 2012 May 5 doi: 10.1007/s00586-012-2357-1. PMID: 22562689Free PMC Article

Recent systematic reviews

Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731

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