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Dialysis dementia

MedGen UID:
65124
•Concept ID:
C0221040
•
Disease or Syndrome
Synonyms: Dialysis Dementia; Dialysis Encephalopathy; Dialysis encephalopathy; Dialysis encephalopathy syndrome; Progressive Dialysis Encephalopathy
SNOMED CT: Dialysis encephalopathy (9345005); Dialysis dementia (9345005); Dialysis encephalopathy syndrome (9345005)

Definition

A severe, often fatal encephalopathy which has been attributed to accumulation in the brain of aluminum from dialysate prepared with inadequately purified water. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDialysis dementia

Professional guidelines

PubMed

Biotin in the management of uremic neurologic disorders.
Yatzidis H, Koutsicos D, Agroyannis B, Papastephanidis C, Francos-Plemenos M, Delatola Z
Nephron 1984;36(3):183-6. doi: 10.1159/000183149. PMID: 6322032
Results of 12 years' treatment of chronic renal failure by dialysis and transplantation.
Price JD, Ashby KM, Reeve CE
Can Med Assoc J 1978 Feb 4;118(3):263-6. PMID: 343897Free PMC Article

Recent clinical studies

Etiology

Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study.
Ling TC, Chang CC, Li CY, Sung JM, Sun CY, Tsai KJ, Cheng YY, Wu JL, Kuo YT, Chang YT
Eur J Neurol 2022 Jan;29(1):59-68. Epub 2021 Oct 7 doi: 10.1111/ene.15123. PMID: 34561939Free PMC Article
Aluminum in Neurological and Neurodegenerative Disease.
McLachlan DRC, Bergeron C, Alexandrov PN, Walsh WJ, Pogue AI, Percy ME, Kruck TPA, Fang Z, Sharfman NM, Jaber V, Zhao Y, Li W, Lukiw WJ
Mol Neurobiol 2019 Feb;56(2):1531-1538. Epub 2019 Jan 31 doi: 10.1007/s12035-018-1441-x. PMID: 30706368Free PMC Article
Impact of effects of acid precipitation on toxicity of metals.
Nordberg GF, Goyer RA, Clarkson TW
Environ Health Perspect 1985 Nov;63:169-80. doi: 10.1289/ehp.8563169. PMID: 3908087Free PMC Article
Effect of dialysis on plasma and CSF tryptophan and CSF 5-hydroxyindoleacetic acid in advanced renal disease.
Sullivan PA, Murnaghan D, Callaghan N, Kantamaneni BD, Curzon G
J Neurol Neurosurg Psychiatry 1980 Aug;43(8):739-43. doi: 10.1136/jnnp.43.8.739. PMID: 6159456Free PMC Article
Dementia, renal failure, and brain aluminum.
Arieff AI, Cooper JD, Armstrong D, Lazarowitz VC
Ann Intern Med 1979 May;90(5):741-7. doi: 10.7326/0003-4819-90-5-741. PMID: 434672

Diagnosis

Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study.
Ling TC, Chang CC, Li CY, Sung JM, Sun CY, Tsai KJ, Cheng YY, Wu JL, Kuo YT, Chang YT
Eur J Neurol 2022 Jan;29(1):59-68. Epub 2021 Oct 7 doi: 10.1111/ene.15123. PMID: 34561939Free PMC Article
Renal Disease and Neurology.
Hocker SE
Continuum (Minneap Minn) 2017 Jun;23(3, Neurology of Systemic Disease):722-743. doi: 10.1212/CON.0000000000000469. PMID: 28570326
Metabolic encephalopathy as a complication of renal failure: mechanisms and mediators.
Fraser CL, Arieff AI
New Horiz 1994 Nov;2(4):518-26. PMID: 7804801
Nervous system complications in uremia.
Fraser CL, Arieff AI
Ann Intern Med 1988 Jul 15;109(2):143-53. doi: 10.7326/0003-4819-109-2-143. PMID: 2837930
Pathogenesis of dialysis encephalopathy.
Arieff AI, Mahoney CA
Neurobehav Toxicol Teratol 1983 Nov-Dec;5(6):641-4. PMID: 6366603

Therapy

Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review.
Esparza JL, Gómez M, Domingo JL
Biol Trace Elem Res 2019 Mar;188(1):60-67. Epub 2018 May 7 doi: 10.1007/s12011-018-1372-4. PMID: 29732485
Nervous system disorders in dialysis patients.
Bansal VK, Bansal S
Handb Clin Neurol 2014;119:395-404. doi: 10.1016/B978-0-7020-4086-3.00025-4. PMID: 24365308
Neurology and the kidney.
Burn DJ, Bates D
J Neurol Neurosurg Psychiatry 1998 Dec;65(6):810-21. doi: 10.1136/jnnp.65.6.810. PMID: 9854955Free PMC Article
Dialysis dementia.
Mach JR Jr, Korchik WP, Mahowald MW
Clin Geriatr Med 1988 Nov;4(4):853-67. PMID: 3066464
Dialysis dementia.
Br Med J 1976 Nov 20;2(6046):1213-4. PMID: 990852Free PMC Article

Prognosis

Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study.
Ling TC, Chang CC, Li CY, Sung JM, Sun CY, Tsai KJ, Cheng YY, Wu JL, Kuo YT, Chang YT
Eur J Neurol 2022 Jan;29(1):59-68. Epub 2021 Oct 7 doi: 10.1111/ene.15123. PMID: 34561939Free PMC Article
Neurological manifestations of uraemia and chronic dialysis.
Tzamaloukas AH, Agaba EI
Niger J Med 2004 Apr-Jun;13(2):98-105. PMID: 15293824
National surveillance of dialysis-associated diseases in the United States, 1988.
Alter MJ, Favero MS, Moyer LA, Miller JK, Bland LA
ASAIO Trans 1990 Apr-Jun;36(2):107-18. doi: 10.1097/00002480-199004000-00012. PMID: 2140268
Progressive dialysis encephalopathy ("dialysis dementia").
Chui HC, Damasio AR
J Neurol 1980 Jan;222(3):145-57. doi: 10.1007/BF00313113. PMID: 6153702
Results of 12 years' treatment of chronic renal failure by dialysis and transplantation.
Price JD, Ashby KM, Reeve CE
Can Med Assoc J 1978 Feb 4;118(3):263-6. PMID: 343897Free PMC Article

Clinical prediction guides

Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study.
Ling TC, Chang CC, Li CY, Sung JM, Sun CY, Tsai KJ, Cheng YY, Wu JL, Kuo YT, Chang YT
Eur J Neurol 2022 Jan;29(1):59-68. Epub 2021 Oct 7 doi: 10.1111/ene.15123. PMID: 34561939Free PMC Article
Effects of acute exposure to aluminum on cognition in humans.
Molloy DW, Standish TI, Nieboer E, Turnbull JD, Smith SD, Dubois S
J Toxicol Environ Health A 2007 Dec;70(23):2011-9. doi: 10.1080/15287390701551142. PMID: 17966072
Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia.
Maesaka JK, Palaia T, Fishbane S, Ragolia L
Semin Nephrol 2002 Sep;22(5):407-14. doi: 10.1053/snep.2002.34726. PMID: 12224048
Aluminum, parathyroid hormone, and osteomalacia.
Burnatowska-Hledin MA, Kaiser L, Mayor GH
Spec Top Endocrinol Metab 1983;5:201-26. PMID: 6422572
Plasma exchange in neurological diseases. A critical approach.
Valbonesi M, Garelli S
Vox Sang 1983;44(2):65-80. doi: 10.1111/j.1423-0410.1983.tb04105.x. PMID: 6187131

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