Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Eunuchism

MedGen UID:: 65949
•Concept ID:: C0238117
•: Disease or Syndrome

Synonyms:	eunuchism; hypergonadotropic hypogonadism (Male); Male hypergonadotropic hypogonadism; Primary testicular failure
SNOMED CT:	Eunuchism (267403002)

Monarch Initiative:	MONDO:0005758

Definition

The state of being a eunuch, a male without testes or whose testes failed to develop. It is characterized by the lack of mature male germ cells and testicular hormones. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEunuchism

Pathological process
- Disease
  - Disorder by Site
    - Disorder of endocrine system
      - Gonadal disorder
        Hypogonadism
        Eunuchism

Professional guidelines

PubMed

Advances in the treatment of functional male hypogonadism.

Corona G, Rastrelli G, Sparano C, Vignozzi L, Sforza A, Maggi M
Expert Rev Endocrinol Metab 2024 Mar;19(2):163-177. Epub 2023 Dec 20 doi: 10.1080/17446651.2023.2296022. PMID: 38117229

Enclomiphene citrate for the treatment of secondary male hypogonadism.

Rodriguez KM, Pastuszak AW, Lipshultz LI
Expert Opin Pharmacother 2016 Aug;17(11):1561-7. Epub 2016 Jul 4 doi: 10.1080/14656566.2016.1204294. PMID: 27337642 Free PMC Article

Diagnosis and management of testosterone deficiency.

McBride JA, Carson CC, Coward RM
Asian J Androl 2015 Mar-Apr;17(2):177-86. doi: 10.4103/1008-682X.143317. PMID: 25532575 Free PMC Article

See all (24)

Recent clinical studies

Etiology

Testosterone replacement therapy.

Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334

Metabolic Syndrome in Male Hypogonadism.

Rastrelli G, Filippi S, Sforza A, Maggi M, Corona G
Front Horm Res 2018;49:131-155. Epub 2018 May 24 doi: 10.1159/000485999. PMID: 29895018

Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study.

Rao A, Steels E, Inder WJ, Abraham S, Vitetta L
Aging Male 2016 Jun;19(2):134-42. Epub 2016 Jan 20 doi: 10.3109/13685538.2015.1135323. PMID: 26791805

Obesity and late-onset hypogonadism.

Corona G, Vignozzi L, Sforza A, Mannucci E, Maggi M
Mol Cell Endocrinol 2015 Dec 15;418 Pt 2:120-33. Epub 2015 Jul 2 doi: 10.1016/j.mce.2015.06.031. PMID: 26143633

Testosterone and benign prostatic hyperplasia.

Jarvis TR, Chughtai B, Kaplan SA
Asian J Androl 2015 Mar-Apr;17(2):212-6. doi: 10.4103/1008-682X.140966. PMID: 25337845 Free PMC Article

See all (87)

Diagnosis

Testosterone replacement therapy.

Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334

Testosterone and benign prostatic hyperplasia.

Jarvis TR, Chughtai B, Kaplan SA
Asian J Androl 2015 Mar-Apr;17(2):212-6. doi: 10.4103/1008-682X.140966. PMID: 25337845 Free PMC Article

Comparison of questionnaires used for screening and symptom identification in hypogonadal men.

Bernie AM, Scovell JM, Ramasamy R
Aging Male 2014 Dec;17(4):195-8. Epub 2014 Sep 23 doi: 10.3109/13685538.2014.963041. PMID: 25247629

The hidden world of self-castration and testicular self-injury.

Johnson TW, Irwig MS
Nat Rev Urol 2014 May;11(5):297-300. Epub 2014 Apr 8 doi: 10.1038/nrurol.2014.84. PMID: 24709968

Male hypogonadism: more than just a low testosterone.

Pantalone KM, Faiman C
Cleve Clin J Med 2012 Oct;79(10):717-25. doi: 10.3949/ccjm.79a.11174. PMID: 23027731

See all (76)

Therapy

Advances in the treatment of functional male hypogonadism.

Corona G, Rastrelli G, Sparano C, Vignozzi L, Sforza A, Maggi M
Expert Rev Endocrinol Metab 2024 Mar;19(2):163-177. Epub 2023 Dec 20 doi: 10.1080/17446651.2023.2296022. PMID: 38117229

Testosterone replacement therapy.

Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334

Metabolic Syndrome in Male Hypogonadism.

Rastrelli G, Filippi S, Sforza A, Maggi M, Corona G
Front Horm Res 2018;49:131-155. Epub 2018 May 24 doi: 10.1159/000485999. PMID: 29895018

Enclomiphene citrate for the treatment of secondary male hypogonadism.

Rodriguez KM, Pastuszak AW, Lipshultz LI
Expert Opin Pharmacother 2016 Aug;17(11):1561-7. Epub 2016 Jul 4 doi: 10.1080/14656566.2016.1204294. PMID: 27337642 Free PMC Article

Obesity and late-onset hypogonadism.

Corona G, Vignozzi L, Sforza A, Mannucci E, Maggi M
Mol Cell Endocrinol 2015 Dec 15;418 Pt 2:120-33. Epub 2015 Jul 2 doi: 10.1016/j.mce.2015.06.031. PMID: 26143633

See all (117)

Prognosis

Late-onset Hypogonadism: Bone health.

Rochira V
Andrology 2020 Nov;8(6):1539-1550. Epub 2020 Jun 17 doi: 10.1111/andr.12827. PMID: 32469467

Late-onset hypogonadism: Prostate safety.

Miranda EP, Torres LO
Andrology 2020 Nov;8(6):1606-1613. Epub 2020 Feb 28 doi: 10.1111/andr.12772. PMID: 32056383

Metabolic Syndrome in Male Hypogonadism.

Rastrelli G, Filippi S, Sforza A, Maggi M, Corona G
Front Horm Res 2018;49:131-155. Epub 2018 May 24 doi: 10.1159/000485999. PMID: 29895018

Comparison of questionnaires used for screening and symptom identification in hypogonadal men.

Bernie AM, Scovell JM, Ramasamy R
Aging Male 2014 Dec;17(4):195-8. Epub 2014 Sep 23 doi: 10.3109/13685538.2014.963041. PMID: 25247629

The hidden world of self-castration and testicular self-injury.

Johnson TW, Irwig MS
Nat Rev Urol 2014 May;11(5):297-300. Epub 2014 Apr 8 doi: 10.1038/nrurol.2014.84. PMID: 24709968

See all (27)

Clinical prediction guides

Testosterone replacement therapy.

Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334

Late-onset hypogonadism: Prostate safety.

Miranda EP, Torres LO
Andrology 2020 Nov;8(6):1606-1613. Epub 2020 Feb 28 doi: 10.1111/andr.12772. PMID: 32056383

Metabolic Syndrome in Male Hypogonadism.

Rastrelli G, Filippi S, Sforza A, Maggi M, Corona G
Front Horm Res 2018;49:131-155. Epub 2018 May 24 doi: 10.1159/000485999. PMID: 29895018

Rao A, Steels E, Inder WJ, Abraham S, Vitetta L
Aging Male 2016 Jun;19(2):134-42. Epub 2016 Jan 20 doi: 10.3109/13685538.2015.1135323. PMID: 26791805

Comparison of questionnaires used for screening and symptom identification in hypogonadal men.

Bernie AM, Scovell JM, Ramasamy R
Aging Male 2014 Dec;17(4):195-8. Epub 2014 Sep 23 doi: 10.3109/13685538.2014.963041. PMID: 25247629

See all (57)

Recent systematic reviews

Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.

Tienforti D, Castellini C, Di Giulio F, Totaro M, Dalmazio G, Spagnolo L, Muselli M, Corona G, Baroni MG, Barbonetti A
Andrology 2023 Sep;11(6):1067-1076. Epub 2023 Jan 18 doi: 10.1111/andr.13373. PMID: 36604313

Effects of treatment for diabetes mellitus on testosterone concentrations: A systematic review.

Van Cauwenberghe J, De Block C, Vanderschueren D, Antonio L
Andrology 2023 Feb;11(2):225-233. Epub 2022 Nov 11 doi: 10.1111/andr.13318. PMID: 36251281

The effect of testosterone replacement therapy on prostate-specific antigen (PSA) levels in men being treated for hypogonadism: a systematic review and meta-analysis.

Kang DY, Li HJ
Medicine (Baltimore) 2015 Jan;94(3):e410. doi: 10.1097/MD.0000000000000410. PMID: 25621688 Free PMC Article

The effect of androgen-replacement therapy on prostate growth: a systematic review and meta-analysis.

Cui Y, Zhang Y
Eur Urol 2013 Nov;64(5):811-22. Epub 2013 Apr 3 doi: 10.1016/j.eururo.2013.03.042. PMID: 23567065

See all (4)

MedGen

National Center for Biotechnology Information

Send to:

Eunuchism

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity