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Lyme arthritis

MedGen UID:
66074
•Concept ID:
C0242381
•
Disease or Syndrome
Synonyms: Arthritis, Lyme; Lyme Arthritis
SNOMED CT: Arthritis in Lyme disease (33937009); Lyme arthritis (33937009)

Definition

Joint inflammation, most often affecting large joints, associated with Lyme disease, presenting months after infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme arthritis

Professional guidelines

PubMed

Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis.
Steere AC, Angelis SM
Arthritis Rheum 2006 Oct;54(10):3079-86. doi: 10.1002/art.22131. PMID: 17009226

Recent clinical studies

Etiology

Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Lyme disease.
Evans J
Curr Opin Rheumatol 2000 Jul;12(4):311-7. doi: 10.1097/00002281-200007000-00014. PMID: 10910185
Psoriasis and Lyme arthritis.
Bianchi G, Buffrini L, Grignolo MC, Rovetta G, Crovato F, Monteforte P
Acta Derm Venereol Suppl (Stockh) 1994;186:119-20. PMID: 8073810
Lyme disease: an orthopedic perspective.
Lawrence SJ
Orthopedics 1992 Nov;15(11):1331-5. doi: 10.3928/0147-7447-19921101-12. PMID: 1461815

Diagnosis

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Lyme Arthritis.
Chan SS, Pollock AN
Pediatr Emerg Care 2015 Sep;31(9):680-1. doi: 10.1097/PEC.0000000000000576. PMID: 26335237
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Therapy

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Prognosis

Hemarthrosis in a Pediatric Patient With Immune Thrombocytopenia and Lyme Arthritis.
Wheeler JA, Rodriguez V, Jacobson-Kelly AE
J Pediatr Hematol Oncol 2024 Jan 1;46(1):e115-e117. Epub 2023 Nov 2 doi: 10.1097/MPH.0000000000002780. PMID: 37916847
Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Evans J
Curr Opin Rheumatol 2000 Jul;12(4):311-7. doi: 10.1097/00002281-200007000-00014. PMID: 10910185

Clinical prediction guides

Sleep fragmentation disrupts Lyme arthritis resolution in mice.
Jackson CD, Badran M, Gozal D, Brown CR, Khalyfa A
Sleep Med 2024 Feb;114:196-202. Epub 2024 Jan 11 doi: 10.1016/j.sleep.2024.01.011. PMID: 38219655
A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.
Brouwer MAE, van de Schoor FR, Vrijmoeth HD, Netea MG, Joosten LAB
Immunol Rev 2020 Mar;294(1):63-79. Epub 2020 Jan 13 doi: 10.1111/imr.12837. PMID: 31930745Free PMC Article
Non-Hodgkin Lymphoma with Synovial Involvement of the Knee.
Kim B, Raphael B, Liu C, Golden BD
Bull Hosp Jt Dis (2013) 2019 Dec;77(4):275-278. PMID: 31785142
Immunology of reactive arthritides.
Burmester GR, Daser A, Kamradt T, Krause A, Mitchison NA, Sieper J, Wolf N
Annu Rev Immunol 1995;13:229-50. doi: 10.1146/annurev.iy.13.040195.001305. PMID: 7612222
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Recent systematic reviews

Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015-2017.
Geebelen L, Van Cauteren D, Devleesschauwer B, Moreels S, Tersago K, Van Oyen H, Speybroeck N, Lernout T
Ticks Tick Borne Dis 2019 Apr;10(3):598-605. Epub 2018 Dec 28 doi: 10.1016/j.ttbdis.2018.12.007. PMID: 30772196
Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution.
Jarosz AC, Badawi A
Inflamm Res 2019 Jan;68(1):7-17. Epub 2018 Aug 18 doi: 10.1007/s00011-018-1180-5. PMID: 30121835Free PMC Article

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