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Abnormal red blood cell count

MedGen UID:
663423
•Concept ID:
C0580548
•
Finding
Synonyms: Abnormal RBC count; RBC (red blood cell) count abnormal; Red blood cell count abnormal; Red blood cell count outside reference range
SNOMED CT: Red blood cell count abnormal (165427000); Red blood cell count outside reference range (165427000); RBC (red blood cell) count abnormal (165427000)
 
HPO: HP:0020058

Definition

Any deviation from the normal number of red blood cells per volume in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal red blood cell count

Professional guidelines

PubMed

Hemolytic Anemia: Evaluation and Differential Diagnosis.
Phillips J, Henderson AC
Am Fam Physician 2018 Sep 15;98(6):354-361. PMID: 30215915
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Recent clinical studies

Etiology

Ruxolitinib.
Ajayi S, Becker H, Reinhardt H, Engelhardt M, Zeiser R, von Bubnoff N, Wäsch R
Recent Results Cancer Res 2018;212:119-132. doi: 10.1007/978-3-319-91439-8_6. PMID: 30069628
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura
J Thromb Haemost 2017 Feb;15(2):312-322. Epub 2017 Jan 30 doi: 10.1111/jth.13571. PMID: 27868334
One thousand patients with primary myelofibrosis: the mayo clinic experience.
Tefferi A, Lasho TL, Jimma T, Finke CM, Gangat N, Vaidya R, Begna KH, Al-Kali A, Ketterling RP, Hanson CA, Pardanani A
Mayo Clin Proc 2012 Jan;87(1):25-33. doi: 10.1016/j.mayocp.2011.11.001. PMID: 22212965Free PMC Article
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Diagnosis

Hemolytic Anemia: Evaluation and Differential Diagnosis.
Phillips J, Henderson AC
Am Fam Physician 2018 Sep 15;98(6):354-361. PMID: 30215915
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura
J Thromb Haemost 2017 Feb;15(2):312-322. Epub 2017 Jan 30 doi: 10.1111/jth.13571. PMID: 27868334
One thousand patients with primary myelofibrosis: the mayo clinic experience.
Tefferi A, Lasho TL, Jimma T, Finke CM, Gangat N, Vaidya R, Begna KH, Al-Kali A, Ketterling RP, Hanson CA, Pardanani A
Mayo Clin Proc 2012 Jan;87(1):25-33. doi: 10.1016/j.mayocp.2011.11.001. PMID: 22212965Free PMC Article
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Therapy

Monoclonal gammopathy-associated pure red cell aplasia.
Korde N, Zhang Y, Loeliger K, Poon A, Simakova O, Zingone A, Costello R, Childs R, Noel P, Silver S, Kwok M, Mo C, Young N, Landgren O, Sloand E, Maric I
Br J Haematol 2016 Jun;173(6):876-83. Epub 2016 Mar 21 doi: 10.1111/bjh.14012. PMID: 26999424Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2012 Jul 11;(7):CD003426. doi: 10.1002/14651858.CD003426.pub4. PMID: 22786485
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Singh PC, Ballas SK
Cochrane Database Syst Rev 2007 Oct 17;(4):CD003426. doi: 10.1002/14651858.CD003426.pub2. PMID: 17943791
Congenital hypoplastic anemia.
Diamond LK, Wang WC, Alter BP
Adv Pediatr 1976;22:349-78. PMID: 773132

Prognosis

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
One thousand patients with primary myelofibrosis: the mayo clinic experience.
Tefferi A, Lasho TL, Jimma T, Finke CM, Gangat N, Vaidya R, Begna KH, Al-Kali A, Ketterling RP, Hanson CA, Pardanani A
Mayo Clin Proc 2012 Jan;87(1):25-33. doi: 10.1016/j.mayocp.2011.11.001. PMID: 22212965Free PMC Article
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912
Congenital hypoplastic anemia.
Diamond LK, Wang WC, Alter BP
Adv Pediatr 1976;22:349-78. PMID: 773132

Clinical prediction guides

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Determining mean corpuscular volume and red blood cell count using electrochemical collision events.
Ho TLT, Hoang NTT, Lee J, Park JH, Kim BK
Biosens Bioelectron 2018 Jul 1;110:155-159. Epub 2018 Mar 26 doi: 10.1016/j.bios.2018.03.053. PMID: 29609162
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
One thousand patients with primary myelofibrosis: the mayo clinic experience.
Tefferi A, Lasho TL, Jimma T, Finke CM, Gangat N, Vaidya R, Begna KH, Al-Kali A, Ketterling RP, Hanson CA, Pardanani A
Mayo Clin Proc 2012 Jan;87(1):25-33. doi: 10.1016/j.mayocp.2011.11.001. PMID: 22212965Free PMC Article
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2012 Jul 11;(7):CD003426. doi: 10.1002/14651858.CD003426.pub4. PMID: 22786485
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Singh PC, Ballas SK
Cochrane Database Syst Rev 2007 Oct 17;(4):CD003426. doi: 10.1002/14651858.CD003426.pub2. PMID: 17943791
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Riddington C, De Franceschi L
Cochrane Database Syst Rev 2002;(4):CD003426. doi: 10.1002/14651858.CD003426. PMID: 12519597

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