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Vaginal squamous cell carcinoma

MedGen UID:
66775
•Concept ID:
C0238518
•
Neoplastic Process
Synonyms: carcinoma of vagina squamous cell; epidermoid carcinoma of the vagina; epidermoid carcinoma of vagina; epidermoid cell carcinoma of the vagina; epidermoid cell carcinoma of vagina; Squamous cell cancer of vagina; squamous cell carcinoma of the vagina; squamous cell carcinoma of the vulva/vagina; Squamous cell carcinoma of vagina; squamous cell carcinoma of vagina; vagina epidermoid carcinoma; vagina epidermoid cell carcinoma; vagina squamous cell carcinoma; vaginal epidermoid carcinoma; vaginal epidermoid cell carcinoma; vaginal squamous cell cancer; vaginal squamous cell cancer, NOS; Vaginal Squamous Cell Carcinoma; vaginal squamous cell carcinoma; Vaginal Squamous Cell Carcinoma, NOS; Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
SNOMED CT: Squamous cell carcinoma of vagina (105121000119102); Squamous cell cancer of vagina (105121000119102)
 
Monarch Initiative: MONDO:0006490

Definition

Vaginal squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available. [from NCI]

Professional guidelines

PubMed

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Cervical cancer screening clinical practice guidelines in oncology.
Partridge EE, Abu-Rustum NR, Campos S, Edelson M, Fahey PJ, Fiorica J, Greer BE, Lieberman RW, Likes W, Molpus KL, Nava ME, Reynolds RK, Singh DK, Smith-McCune K, Soper J, Teng N, Trimble CL, Wilczynski S; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2004 Nov;2(6):570-87. doi: 10.6004/jnccn.2004.0048. PMID: 19780301
Current concepts in obstetrics and gynecology: The patient with an abnormal Pap smear--screening techniques and management.
Richart RM
N Engl J Med 1980 Feb 7;302(6):332-4. doi: 10.1056/NEJM198002073020606. PMID: 6985710

Recent clinical studies

Etiology

Outcomes of vaginal squamous cell carcinoma of patients treated with radiation therapy: a series of 37 patients from a single expert center.
Romano E, Janati S, Monnier L, Darai É, Bendifallah S, Schlienger M, Touboul E, Rivin Del Campo E, Huguet F
Clin Transl Oncol 2020 Aug;22(8):1345-1354. Epub 2019 Dec 23 doi: 10.1007/s12094-019-02264-y. PMID: 31873914
Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database.
Ghezelayagh T, Rauh-Hain JA, Growdon WB
Obstet Gynecol 2015 Jun;125(6):1353-1361. doi: 10.1097/AOG.0000000000000861. PMID: 26000506
Rapid progression of primary vaginal squamous cell carcinoma in a young HIV-infected woman.
Lee YC, Holcomb K, Buhl A, Holden J, Abulafia O
Gynecol Oncol 2000 Sep;78(3 Pt 1):380-2. doi: 10.1006/gyno.2000.5924. PMID: 10985898

Diagnosis

An Unusual Manifestation of Elevated Liver Enzymes and Architecture.
Wasserman R, Reddy S, Grider D
Gastroenterology 2023 Sep;165(3):e4-e6. Epub 2022 Dec 31 doi: 10.1053/j.gastro.2022.12.032. PMID: 36596397
Advanced primary vaginal squamous cell carcinoma: A case report and literature review.
Shen Y, Meng X, Wang L, Wang X, Chang H
Front Immunol 2022;13:1007462. Epub 2022 Nov 22 doi: 10.3389/fimmu.2022.1007462. PMID: 36483563Free PMC Article
Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database.
Ghezelayagh T, Rauh-Hain JA, Growdon WB
Obstet Gynecol 2015 Jun;125(6):1353-1361. doi: 10.1097/AOG.0000000000000861. PMID: 26000506

Therapy

Outcomes of vaginal squamous cell carcinoma of patients treated with radiation therapy: a series of 37 patients from a single expert center.
Romano E, Janati S, Monnier L, Darai É, Bendifallah S, Schlienger M, Touboul E, Rivin Del Campo E, Huguet F
Clin Transl Oncol 2020 Aug;22(8):1345-1354. Epub 2019 Dec 23 doi: 10.1007/s12094-019-02264-y. PMID: 31873914
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Definitive Radiotherapy for Primary Squamous Cell Carcinoma of the Vagina: Are High-Dose External Beam Radiotherapy and High-Dose-Rate Brachytherapy Boost the Best Treatment? Experience of Two Italian Institutes.
Laliscia C, Gadducci A, Fabrini MG, Barcellini A, Guerrieri ME, Parietti E, Ursino S, Morganti R, Cafaro I, Paiar F
Oncol Res Treat 2017;40(11):697-701. Epub 2017 Oct 20 doi: 10.1159/000480350. PMID: 29065399
Sustained complete remission with taxane-based chemotherapy in stage IVB primary vaginal squamous cell carcinoma.
Aggarwal S, Goel G, Banerji N, Khullar H
Hematol Oncol Stem Cell Ther 2009;2(2):362-3. doi: 10.1016/s1658-3876(09)50027-1. PMID: 20118062
Exclusive radiotherapy for primary squamous cell carcinoma of the vagina.
de Crevoisier R, Sanfilippo N, Gerbaulet A, Morice P, Pomel C, Castaigne D, Pautier P, Lhomme C, Duvillard P, Haie-meder C
Radiother Oncol 2007 Dec;85(3):362-70. Epub 2007 Oct 25 doi: 10.1016/j.radonc.2007.09.015. PMID: 17963909

Prognosis

Time trends in the incidence and survival of vaginal squamous cell carcinoma and high-grade vaginal intraepithelial neoplasia in Denmark - A nationwide population-based study.
Bertoli HK, Baandrup L, Aalborg GL, Kjaer AK, Thomsen LT, Kjaer SK
Gynecol Oncol 2020 Sep;158(3):734-739. Epub 2020 Jun 19 doi: 10.1016/j.ygyno.2020.05.683. PMID: 32571683
Outcomes of vaginal squamous cell carcinoma of patients treated with radiation therapy: a series of 37 patients from a single expert center.
Romano E, Janati S, Monnier L, Darai É, Bendifallah S, Schlienger M, Touboul E, Rivin Del Campo E, Huguet F
Clin Transl Oncol 2020 Aug;22(8):1345-1354. Epub 2019 Dec 23 doi: 10.1007/s12094-019-02264-y. PMID: 31873914
Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.
Han T, Jin Y, Li Y, Bi Y, Pan L
Medicine (Baltimore) 2018 Dec;97(49):e13470. doi: 10.1097/MD.0000000000013470. PMID: 30544435Free PMC Article
Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database.
Ghezelayagh T, Rauh-Hain JA, Growdon WB
Obstet Gynecol 2015 Jun;125(6):1353-1361. doi: 10.1097/AOG.0000000000000861. PMID: 26000506
Uterine prolapse complicated by vaginal cancer: a case report and literature review.
Wang Y, Li Q, Du H, Lv S, Liu H
Gynecol Obstet Invest 2014;77(2):141-4. Epub 2014 Jan 23 doi: 10.1159/000357566. PMID: 24481208

Clinical prediction guides

Time trends in the incidence and survival of vaginal squamous cell carcinoma and high-grade vaginal intraepithelial neoplasia in Denmark - A nationwide population-based study.
Bertoli HK, Baandrup L, Aalborg GL, Kjaer AK, Thomsen LT, Kjaer SK
Gynecol Oncol 2020 Sep;158(3):734-739. Epub 2020 Jun 19 doi: 10.1016/j.ygyno.2020.05.683. PMID: 32571683
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Primary vaginal squamous cell carcinoma in the young patient.
Di Domenico A
Gynecol Oncol 1989 Nov;35(2):181-7. doi: 10.1016/0090-8258(89)90040-1. PMID: 2680798

Recent systematic reviews

Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092

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