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hypoxia

MedGen UID:
66846
•Concept ID:
C0242184
•
Pathologic Function
Synonyms: Deficiencies, Oxygen; Deficiency, Oxygen; Hypoxia; Oxygen Deficiencies; Oxygen Deficiency
SNOMED CT: Hypoxia (389086002); Decreased oxygen supply (389086002); Hypoxic (389086002)

Definition

A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). [from NCI]

Professional guidelines

PubMed

Shock: aetiology, pathophysiology and management.
Blumlein D, Griffiths I
Br J Nurs 2022 Apr 21;31(8):422-428. doi: 10.12968/bjon.2022.31.8.422. PMID: 35439071
COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management.
Ochani R, Asad A, Yasmin F, Shaikh S, Khalid H, Batra S, Sohail MR, Mahmood SF, Ochani R, Hussham Arshad M, Kumar A, Surani S
Infez Med 2021 Mar 1;29(1):20-36. PMID: 33664170
Primary Dysmenorrhea: Assessment and Treatment.
Guimarães I, Póvoa AM
Rev Bras Ginecol Obstet 2020 Aug;42(8):501-507. Epub 2020 Jun 19 doi: 10.1055/s-0040-1712131. PMID: 32559803Free PMC Article

Recent clinical studies

Etiology

Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities.
Beckers C, Pruschy M, Vetrugno I
Semin Cancer Biol 2024 Jan;98:19-30. Epub 2023 Nov 29 doi: 10.1016/j.semcancer.2023.11.006. PMID: 38040401
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher J, Mallet RT, Burtscher M, Millet GP
Ageing Res Rev 2021 Jul;68:101343. Epub 2021 Apr 15 doi: 10.1016/j.arr.2021.101343. PMID: 33862277
Genetics of the hypoxia-inducible factors in human cancers.
Tanimoto K
Exp Cell Res 2017 Jul 15;356(2):166-172. Epub 2017 Mar 18 doi: 10.1016/j.yexcr.2017.03.035. PMID: 28322821
High altitude illness.
Hartman-Ksycińska A, Kluz-Zawadzka J, Lewandowski B
Przegl Epidemiol 2016;70(3):490-499. PMID: 27888818
ECMO--long term follow-up.
Bohn D
Paediatr Respir Rev 2006;7 Suppl 1:S194-5. Epub 2006 Jun 6 doi: 10.1016/j.prrv.2006.04.204. PMID: 16798561

Diagnosis

Hypoxia and Metabolism in Metastasis.
Zhang T, Suo C, Zheng C, Zhang H
Adv Exp Med Biol 2019;1136:87-95. doi: 10.1007/978-3-030-12734-3_6. PMID: 31201718
Neonatal electroencephalography recordings.
Yao D, Deng X, Wang M
Minerva Pediatr 2019 Jun;71(3):304-308. Epub 2016 Jul 21 doi: 10.23736/S0026-4946.16.04711-3. PMID: 27441493
Severe exercise-induced hypoxemia.
Garvey C, Tiep B, Carter R, Barnett M, Hart M, Casaburi R
Respir Care 2012 Jul;57(7):1154-60. Epub 2012 Feb 10 doi: 10.4187/respcare.01469. PMID: 22325845
Hypoxia-inducible factor-1 (HIF-1).
Ke Q, Costa M
Mol Pharmacol 2006 Nov;70(5):1469-80. Epub 2006 Aug 3 doi: 10.1124/mol.106.027029. PMID: 16887934
Occupational methaemoglobinaemia.
Bradberry SM, Aw TC, Williams NR, Vale JA
Occup Environ Med 2001 Sep;58(9):611-5; quiz 616. doi: 10.1136/oem.58.9.611. PMID: 11511749Free PMC Article

Therapy

Estimating Cardiovascular Benefits of Tirzepatide in Sleep Apnea and Obesity: Insight from the SURMOUNT-OSA Trials.
Beccuti G, Bioletto F, Parasiliti-Caprino M, Benso A, Ghigo E, Cicolin A, Broglio F
Curr Obes Rep 2024 Dec;13(4):739-742. Epub 2024 Oct 8 doi: 10.1007/s13679-024-00592-x. PMID: 39378016Free PMC Article
Targeted Therapies in Pheochromocytoma and Paraganglioma.
Wang K, Crona J, Beuschlein F, Grossman AB, Pacak K, Nölting S
J Clin Endocrinol Metab 2022 Nov 23;107(11):2963-2972. doi: 10.1210/clinem/dgac471. PMID: 35973976Free PMC Article
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Hyperbaric oxygen therapy and cancer--a review.
Moen I, Stuhr LE
Target Oncol 2012 Dec;7(4):233-42. Epub 2012 Oct 2 doi: 10.1007/s11523-012-0233-x. PMID: 23054400Free PMC Article
Intraperitoneal photodynamic therapy.
Cengel KA, Glatstein E, Hahn SM
Cancer Treat Res 2007;134:493-514. doi: 10.1007/978-0-387-48993-3_34. PMID: 17633077

Prognosis

Hypoxia During One-Lung Ventilation-A Review and Update.
Campos JH, Feider A
J Cardiothorac Vasc Anesth 2018 Oct;32(5):2330-2338. Epub 2017 Dec 19 doi: 10.1053/j.jvca.2017.12.026. PMID: 29361458
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018.
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Hypothermia and neonatal encephalopathy.
Committee on Fetus and Newborn, Papile LA, Baley JE, Benitz W, Cummings J, Carlo WA, Eichenwald E, Kumar P, Polin RA, Tan RC, Wang KS
Pediatrics 2014 Jun;133(6):1146-50. doi: 10.1542/peds.2014-0899. PMID: 24864176
Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.
Kurinczuk JJ, White-Koning M, Badawi N
Early Hum Dev 2010 Jun;86(6):329-38. Epub 2010 Jun 16 doi: 10.1016/j.earlhumdev.2010.05.010. PMID: 20554402
Cot deaths.
J R Coll Gen Pract 1972 Oct;22(123):651-2. PMID: 5084460Free PMC Article

Clinical prediction guides

Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Comparing the Effectiveness of Methods to Measure Oxygen in Tissues for Prognosis and Treatment of Cancer.
Flood AB, Satinsky VA, Swartz HM
Adv Exp Med Biol 2016;923:113-120. doi: 10.1007/978-3-319-38810-6_15. PMID: 27526132Free PMC Article
Technical innovation in adjuvant radiotherapy: Evolution and evaluation of new treatments for today and tomorrow.
Kunkler IH, Ward C, Langdon SP
Breast 2015 Nov;24 Suppl 2:S114-9. Epub 2015 Oct 1 doi: 10.1016/j.breast.2015.07.026. PMID: 26429399
Post-anoxic vegetative state: imaging and prognostic perspectives.
Stanziano M, Foglia C, Soddu A, Gargano F, Papa M
Funct Neurol 2011 Jan-Mar;26(1):45-50. PMID: 21693088Free PMC Article
Arterial blood gas monitoring.
Gilbert HC, Vender JS
Crit Care Clin 1995 Jan;11(1):233-48. PMID: 7736269

Recent systematic reviews

Advances in pathogenesis of preeclampsia.
Yang M, Wang M, Li N
Arch Gynecol Obstet 2024 May;309(5):1815-1823. Epub 2024 Feb 29 doi: 10.1007/s00404-024-07393-6. PMID: 38421424
Cardiovascular and renal safety outcomes of hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat for anemia patients with chronic kidney disease: a systematic review and meta-analysis.
Tian L, Wang M, Liu M, Pang Y, Zhao J, Zheng B, Wang Y, Zhao W
Ren Fail 2024 Dec;46(1):2313864. Epub 2024 Feb 12 doi: 10.1080/0886022X.2024.2313864. PMID: 38345037Free PMC Article
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis.
Senefeld JW, Wiggins CC, Regimbal RJ, Dominelli PB, Baker SE, Joyner MJ
Med Sci Sports Exerc 2020 Oct;52(10):2250-2261. doi: 10.1249/MSS.0000000000002363. PMID: 32936597Free PMC Article
Cooling for newborns with hypoxic ischaemic encephalopathy.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article

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