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Kidney papillary necrosis

MedGen UID:: 7212
•Concept ID:: C0022667
•: Disease or Syndrome

Synonyms:	Kidney Papillary Necrosis; Necrosis, Kidney Papillary; Necrosis, Renal Medullary; Necrotizing Renal Papillitides; Necrotizing Renal Papillitis; Papillary Necrosis, Kidney; Papillitides, Necrotizing Renal; Renal Medullary Necrosis; Renal Papillitides, Necrotizing; Renal Papillitis, Necrotizing
SNOMED CT:	Necrotizing papillitis (90241004); Papillary necrosis (90241004); Necrotizing renal papillitis (90241004); Renal papillary necrosis (90241004)

HPO:	HP:0032632
Monarch Initiative:	MONDO:0006821

Definition

Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVKidney papillary necrosis

Congenital Systemic Disorder
- Abnormality of the genitourinary system
  - Abnormality of the urinary system
    - Abnormality of the urinary system physiology
      - Abnormal renal physiology
        Kidney disorder
        Kidney papillary necrosis

Professional guidelines

PubMed

PAPILLARY NECROSIS. PATHOLOGY AND MANAGEMENT OF THE ACUTE ATTACK.

BONNIN N
Am Heart J 1964 Dec;68:842-3. doi: 10.1016/0002-8703(64)90137-1. PMID: 14235965

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Recent clinical studies

Etiology

Over-the-counter analgesic use.

De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685

Herbs and the kidney.

Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
Am J Kidney Dis 2004 Jul;44(1):1-11. doi: 10.1053/j.ajkd.2004.02.009. PMID: 15211432

Whelton A
Am J Ther 2000 Mar;7(2):63-74. doi: 10.1097/00045391-200007020-00004. PMID: 11319575

Renal complications of nonsteroidal antiinflammatory drugs: identification and monitoring of those at risk.

Blackshear JL, Napier JS, Davidman M, Stillman MT
Semin Arthritis Rheum 1985 Feb;14(3):163-75. doi: 10.1016/0049-0172(85)90035-6. PMID: 3909403

Interstitial nephritis. A brief review.

Heptinstall RH
Am J Pathol 1976 Apr;83(1):213-36. PMID: 776003 Free PMC Article

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Diagnosis

Renal Papillary and Calyceal Lesions at CT Urography: Genitourinary Imaging.

Kawamoto S, Duggan P, Sheth S, Miyamoto H, Kazi ZN, Fishman EK
Radiographics 2017 Jan-Feb;37(1):358-359. doi: 10.1148/rg.2017160089. PMID: 28076022

Over-the-counter analgesic use.

De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685

Analgesic nephropathy.

De Broe ME, Elseviers MM
N Engl J Med 1998 Feb 12;338(7):446-52. doi: 10.1056/NEJM199802123380707. PMID: 9459649

Sickle cell disease.

Davies SC, Hewitt PE
Br J Hosp Med 1984 Jun;31(6):440-4. PMID: 6378295

Cryptococcal pyelonephritis.

Randall RE Jr, Stacy WK, Toone EC, Prout GR Jr, Madge GE, Shadomy HJ, Shadomy S, Utz JP
N Engl J Med 1968 Jul 11;279(2):60-5. doi: 10.1056/NEJM196807112790202. PMID: 5657012

See all (171)

Therapy

Over-the-counter analgesic use.

De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685

Analgesic nephropathy.

De Broe ME, Elseviers MM
N Engl J Med 1998 Feb 12;338(7):446-52. doi: 10.1056/NEJM199802123380707. PMID: 9459649

Analgesic nephropathy.

Kennedy A
J Clin Pathol Suppl (R Coll Pathol) 1975;9:14-23. PMID: 783211 Free PMC Article

Aspirin and the kidney.

Wigley RD
N Z Med J 1971 Nov;74(474):301-5. PMID: 4944327

Cryptococcal pyelonephritis.

Randall RE Jr, Stacy WK, Toone EC, Prout GR Jr, Madge GE, Shadomy HJ, Shadomy S, Utz JP
N Engl J Med 1968 Jul 11;279(2):60-5. doi: 10.1056/NEJM196807112790202. PMID: 5657012

See all (253)

Prognosis

Sickle cell trait and renal papillary necrosis.

Li EJ, Carroll VG
Clin Pediatr (Phila) 2014 Sep;53(10):1013-5. Epub 2014 May 7 doi: 10.1177/0009922814533418. PMID: 24807983

Emphysematous pyelonephritis.

Sean TG, Sheshadri S, Saravu K
J Assoc Physicians India 2002 Nov;50:1413-5. PMID: 12583474

Analgesic nephropathy.

Henrich WL
Am J Med Sci 1988 Jun;295(6):561-8. doi: 10.1097/00000441-198806000-00012. PMID: 3291614

Diabetic nephropathy.

Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591

Acetaminophen poisoning and toxicity.

Rumack BH, Matthew H
Pediatrics 1975 Jun;55(6):871-6. PMID: 1134886

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Clinical prediction guides

Prevalence of urinary tract infection during outpatient follow-up after renal transplantation.

Goya N, Tanabe K, Iguchi Y, Oshima T, Yagisawa T, Toma H, Agishi T, Ota K, Takahashi K
Infection 1997 Mar-Apr;25(2):101-5. doi: 10.1007/BF02113586. PMID: 9108185

Diabetic nephropathy.

Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591

Urographic changes in homozygous sickle cell disease.

Odita JC, Ugbodaga CI, Okafor LA, Ojogwu LI, Ogisi OA
Diagn Imaging 1983;52(5):259-63. PMID: 6617427

Phenacetin and analgesic nephropathy.

Burry A, Hopkins J
Med J Aust 1977 Jun 11;1(24):879-82. doi: 10.5694/j.1326-5377.1977.tb131210.x. PMID: 887016

Renal papillary necrosis; observations on five cases.

CATES JE, HEWER TF
Br Med J 1956 May 5;1(4974):1005-8. doi: 10.1136/bmj.1.4974.1005. PMID: 13304409 Free PMC Article

See all (33)