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Posthemorrhagic hydrocephalus

MedGen UID:
721409
•Concept ID:
C1299564
•
Disease or Syndrome
Synonyms: Post Hemorrhagic Hydrocephalus; Post-Hemorrhagic Hydrocephalus; Post-hemorrhagic hydrocephalus
SNOMED CT: Posthemorrhagic hydrocephalus (371116000); Post-hemorrhagic hydrocephalus (371116000)

Definition

An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a later sequela of an intraventricular or subarachnoid hemorrhage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosthemorrhagic hydrocephalus

Professional guidelines

PubMed

Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts.
Robinson S
J Neurosurg Pediatr 2012 Mar;9(3):242-58. doi: 10.3171/2011.12.PEDS11136. PMID: 22380952Free PMC Article
Medical management of neonatal posthemorrhagic hydrocephalus.
Hansen AR, Snyder EY
Neurosurg Clin N Am 1998 Jan;9(1):95-104. PMID: 9405767

Recent clinical studies

Etiology

Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review.
Holste KG, Xia F, Ye F, Keep RF, Xi G
Fluids Barriers CNS 2022 Apr 1;19(1):28. doi: 10.1186/s12987-022-00324-0. PMID: 35365172Free PMC Article
Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.
Koschnitzky JE, Keep RF, Limbrick DD Jr, McAllister JP 2nd, Morris JA, Strahle J, Yung YC
Fluids Barriers CNS 2018 Mar 27;15(1):11. doi: 10.1186/s12987-018-0096-3. PMID: 29587767Free PMC Article
Infantile posthemorrhagic hydrocephalus.
Tsitouras V, Sgouros S
Childs Nerv Syst 2011 Oct;27(10):1595-608. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1521-y. PMID: 21928026
Alternatives to shunting.
Cinalli G
Childs Nerv Syst 1999 Nov;15(11-12):718-31. doi: 10.1007/s003810050461. PMID: 10603013

Diagnosis

Infant Hydrocephalus.
Lu VM, Shimony N, Jallo GI, Niazi TN
Pediatr Rev 2024 Aug 1;45(8):450-460. doi: 10.1542/pir.2023-006318. PMID: 39085190
Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Management of Posthemorrhagic Hydrocephalus.
Nayak N, Sankhla SK
Neurol India 2021 Nov-Dec;69(Supplement):S313-S319. doi: 10.4103/0028-3886.332257. PMID: 35102982
Infantile posthemorrhagic hydrocephalus.
Tsitouras V, Sgouros S
Childs Nerv Syst 2011 Oct;27(10):1595-608. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1521-y. PMID: 21928026
Posthemorrhagic hydrocephalus.
Holt PJ
J Child Neurol 1989;4 Suppl:S23-31. doi: 10.1177/0883073889004001s06. PMID: 2681374

Therapy

Minocycline attenuates hydrocephalus and inhibits iron accumulation, ependymal damage and epiplexus cell activation after intraventricular hemorrhage in aged rats.
Wan Y, Holste KG, Ye F, Hua Y, Keep RF, Xi G
Exp Neurol 2023 Nov;369:114523. Epub 2023 Aug 30 doi: 10.1016/j.expneurol.2023.114523. PMID: 37652293Free PMC Article
Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity.
Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S
Childs Nerv Syst 2022 Mar;38(3):511-520. Epub 2022 Jan 4 doi: 10.1007/s00381-021-05427-x. PMID: 34981170
Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.
Koschnitzky JE, Keep RF, Limbrick DD Jr, McAllister JP 2nd, Morris JA, Strahle J, Yung YC
Fluids Barriers CNS 2018 Mar 27;15(1):11. doi: 10.1186/s12987-018-0096-3. PMID: 29587767Free PMC Article
Complications of endoscopic third ventriculostomy.
Bouras T, Sgouros S
J Neurosurg Pediatr 2011 Jun;7(6):643-9. doi: 10.3171/2011.4.PEDS10503. PMID: 21631203
Alternatives to shunting.
Cinalli G
Childs Nerv Syst 1999 Nov;15(11-12):718-31. doi: 10.1007/s003810050461. PMID: 10603013

Prognosis

Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Biomarkers in adult posthemorrhagic hydrocephalus.
Hua C, Zhao G
Int J Stroke 2017 Aug;12(6):574-579. Epub 2017 Apr 19 doi: 10.1177/1747493017706187. PMID: 28421877
Biomarkers in neonatal posthemorrhagic hydrocephalus.
Merhar S
Neonatology 2012;101(1):1-7. Epub 2011 Jul 27 doi: 10.1159/000323498. PMID: 21791933Free PMC Article
Pediatric neurosonography.
Grant EG, White EM
J Child Neurol 1986 Oct;1(4):319-37. doi: 10.1177/088307388600100403. PMID: 3298401

Clinical prediction guides

Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity.
Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S
Childs Nerv Syst 2022 Mar;38(3):511-520. Epub 2022 Jan 4 doi: 10.1007/s00381-021-05427-x. PMID: 34981170
Early intervention and neurodevelopmental outcome of infants with posthemorrhagic hydrocephalus: A case series and literature review.
Garcia-Navarro V, Perez-Vega C, Robles-Lomelín P, Valdez-Sandoval P, Vazquez PMG, Rodriguez YL, Cortes SGL, Naranjo EC
Clin Neurol Neurosurg 2021 Feb;201:106432. Epub 2020 Dec 17 doi: 10.1016/j.clineuro.2020.106432. PMID: 33383466
Biomarkers in adult posthemorrhagic hydrocephalus.
Hua C, Zhao G
Int J Stroke 2017 Aug;12(6):574-579. Epub 2017 Apr 19 doi: 10.1177/1747493017706187. PMID: 28421877
Biomarkers in neonatal posthemorrhagic hydrocephalus.
Merhar S
Neonatology 2012;101(1):1-7. Epub 2011 Jul 27 doi: 10.1159/000323498. PMID: 21791933Free PMC Article

Recent systematic reviews

CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review.
Ben-Shoshan SD, Lolansen SD, Mathiesen TI, MacAulay N
Acta Neurochir (Wien) 2023 Nov;165(11):3271-3287. Epub 2023 Aug 29 doi: 10.1007/s00701-023-05746-9. PMID: 37642688
Intraventricular hemorrhage and posthemorrhagic hydrocephalus in preterm infants: diagnosis, classification, and treatment options.
Valdez Sandoval P, Hernández Rosales P, Quiñones Hernández DG, Chavana Naranjo EA, García Navarro V
Childs Nerv Syst 2019 Jun;35(6):917-927. Epub 2019 Apr 5 doi: 10.1007/s00381-019-04127-x. PMID: 30953157
Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants.
Mazzola CA, Choudhri AF, Auguste KI, Limbrick DD Jr, Rogido M, Mitchell L, Flannery AM; Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force
J Neurosurg Pediatr 2014 Nov;14 Suppl 1:8-23. doi: 10.3171/2014.7.PEDS14322. PMID: 25988778
Biomarkers in neonatal posthemorrhagic hydrocephalus.
Merhar S
Neonatology 2012;101(1):1-7. Epub 2011 Jul 27 doi: 10.1159/000323498. PMID: 21791933Free PMC Article
Complications of endoscopic third ventriculostomy.
Bouras T, Sgouros S
J Neurosurg Pediatr 2011 Jun;7(6):643-9. doi: 10.3171/2011.4.PEDS10503. PMID: 21631203

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