U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subacute cutaneous lupus erythematosus

MedGen UID:
7403
•Concept ID:
C0024140
•
Disease or Syndrome
Synonyms: Lupus Erythematosus, Cutaneous, Subacute; Lupus Erythematosus, Subacute Cutaneous
SNOMED CT: Subacute cutaneous lupus erythematosus (239891002); SCLE - Subacute cutaneous lupus erythematosus (239891002); SACLE - Subacute cutaneous lupus erythematosus (239891002)
 
Monarch Initiative: MONDO:0015573
Orphanet: ORPHA163525

Definition

A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubacute cutaneous lupus erythematosus
Follow this link to review classifications for Subacute cutaneous lupus erythematosus in Orphanet.

Professional guidelines

PubMed

Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.
Bao A, Petri MA, Fava A, Kang J
Lupus Sci Med 2023 Dec 19;10(2) doi: 10.1136/lupus-2023-001007. PMID: 38114267Free PMC Article
Apremilast for the Treatment of Concomitant Subacute Cutaneous Lupus Erythematosus and Psoriasis.
Tsiogka A, Gerochristou M, Agrogianni A, Gregoriou S, Rigopoulos D, Kontochristopoulos G
Skinmed 2022;20(5):391-392. Epub 2022 Oct 31 PMID: 36314710
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane.
Mayor-Ibarguren A, Roldán-Puchalt MC, Gómez-Fernández C, Albízuri-Prado F, Álvarez-Escola C
JAMA Dermatol 2016 Jan;152(1):109-11. doi: 10.1001/jamadermatol.2015.2702. PMID: 26444320
Drug-induced subacute cutaneous lupus erythematosus: a paradigm for bedside-to-bench patient-oriented translational clinical investigation.
Sontheimer RD, Henderson CL, Grau RH
Arch Dermatol Res 2009 Jan;301(1):65-70. Epub 2008 Sep 17 doi: 10.1007/s00403-008-0890-x. PMID: 18797894
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013

Diagnosis

Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Mimics of Dermatitis.
Bailiff OA, Mowad CM
Immunol Allergy Clin North Am 2021 Aug;41(3):493-515. doi: 10.1016/j.iac.2021.04.009. PMID: 34225903
Omeprazole-Induced Subacute Cutaneous Lupus Erythematosus.
Hall EL, Peravali R, Patel TS
JAMA Dermatol 2020 Sep 1;156(9):1013. doi: 10.1001/jamadermatol.2020.2415. PMID: 32639541Free PMC Article
Proton Pump Inhibitor-Induced Subacute Cutaneous Lupus Erythematosus.
Patel NB, Cuervo-Pardo L, Tan TL, Kundu RV, Chiarella SE
J Allergy Clin Immunol Pract 2020 Jan;8(1):326-327. Epub 2019 Aug 16 doi: 10.1016/j.jaip.2019.07.025. PMID: 31427196
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Therapy

Subacute cutaneous lupus erythematosus induced by Pfizer COVID-19 vaccine.
Magnaterra E, Magliulo M, Mariotti EB, Ruffo DI Calabria V, Quintarelli L, Corrà A, Aimo C, Verdelli A, Caproni M
Ital J Dermatol Venerol 2023 Jun;158(3):266-267. Epub 2023 Mar 7 doi: 10.23736/S2784-8671.23.07373-5. PMID: 36881332
Omeprazole-Induced Subacute Cutaneous Lupus Erythematosus.
Hall EL, Peravali R, Patel TS
JAMA Dermatol 2020 Sep 1;156(9):1013. doi: 10.1001/jamadermatol.2020.2415. PMID: 32639541Free PMC Article
Proton Pump Inhibitor-Induced Subacute Cutaneous Lupus Erythematosus.
Patel NB, Cuervo-Pardo L, Tan TL, Kundu RV, Chiarella SE
J Allergy Clin Immunol Pract 2020 Jan;8(1):326-327. Epub 2019 Aug 16 doi: 10.1016/j.jaip.2019.07.025. PMID: 31427196
Capecitabine-induced Subacute Cutaneous Lupus Erythematosus.
Rocha A, Almeida HL Jr, Zerwes G, Oliveira Filho UL
An Bras Dermatol 2019 Sep-Oct;94(5):618-619. Epub 2019 Sep 30 doi: 10.1016/j.abd.2019.09.004. PMID: 31777367Free PMC Article
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article

Prognosis

Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, Ellis S, Clarke A, Wace H, Martin B, Smith J
Drugs R D 2020 Dec;20(4):319-330. doi: 10.1007/s40268-020-00320-5. PMID: 32960413Free PMC Article
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane.
Mayor-Ibarguren A, Roldán-Puchalt MC, Gómez-Fernández C, Albízuri-Prado F, Álvarez-Escola C
JAMA Dermatol 2016 Jan;152(1):109-11. doi: 10.1001/jamadermatol.2015.2702. PMID: 26444320
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus.
Ryan E, Marshman G, Astill D
Australas J Dermatol 2012 Nov;53(4):303-6. Epub 2011 Dec 29 doi: 10.1111/j.1440-0960.2011.00842.x. PMID: 23157783
Subacute cutaneous lupus erythematosus.
Sontheimer RD
Clin Dermatol 1985 Jul-Sep;3(3):58-68. doi: 10.1016/0738-081x(85)90078-1. PMID: 3880024

Clinical prediction guides

Deucravacitinib in moderate-to-severe psoriasis.
Vu A, Maloney V, Gordon KB
Immunotherapy 2022 Nov;14(16):1279-1290. Epub 2022 Nov 14 doi: 10.2217/imt-2022-0109. PMID: 36373503
Subacute cutaneous lupus erythematosus observed with ciprofloxacin.
Newman AJ, Mullens D, Lin CC, Barr J
BMJ Case Rep 2018 Dec 22;11(1) doi: 10.1136/bcr-2018-227707. PMID: 30580309Free PMC Article
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013
Subacute cutaneous lupus erythematosus.
David-Bajar KM
J Invest Dermatol 1993 Jan;100(1):2S-8S. doi: 10.1111/1523-1747.ep12355164. PMID: 8423385

Recent systematic reviews

COVID-19 and exacerbation of dermatological diseases: A review of the available literature.
Aram K, Patil A, Goldust M, Rajabi F
Dermatol Ther 2021 Nov;34(6):e15113. Epub 2021 Sep 7 doi: 10.1111/dth.15113. PMID: 34453380Free PMC Article
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, Ellis S, Clarke A, Wace H, Martin B, Smith J
Drugs R D 2020 Dec;20(4):319-330. doi: 10.1007/s40268-020-00320-5. PMID: 32960413Free PMC Article
Cutaneous effects of antihypertensive drugs.
Baccino D, Merlo G, Cozzani E, Rosa GM, Tini G, Burlando M, Parodi A
G Ital Dermatol Venereol 2020 Apr;155(2):202-211. Epub 2019 Jun 12 doi: 10.23736/S0392-0488.19.06360-0. PMID: 31195782
A systematic review of drug-induced subacute cutaneous lupus erythematosus.
Lowe GC, Henderson CL, Grau RH, Hansen CB, Sontheimer RD
Br J Dermatol 2011 Mar;164(3):465-72. Epub 2011 Feb 17 doi: 10.1111/j.1365-2133.2010.10110.x. PMID: 21039412
Lupus erythematosus and other autoimmune diseases related to statin therapy: a systematic review.
Noël B
J Eur Acad Dermatol Venereol 2007 Jan;21(1):17-24. doi: 10.1111/j.1468-3083.2006.01838.x. PMID: 17207162

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...