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Epithelioid cell nevus

MedGen UID:
75480
•Concept ID:
C0259820
•
Neoplastic Process
Synonyms: Epithelioid Cell Nevus; epithelioid cell nevus
SNOMED CT: Epithelioid cell nevus (11099005)
 
Monarch Initiative: MONDO:0044795

Definition

A Spitz nevus characterized by the presence of large epithelioid melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid cell nevus

Professional guidelines

PubMed

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Recent clinical studies

Etiology

Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy.
Kaye VN, Dehner LP
Arch Dermatol 1990 Dec;126(12):1581-3. PMID: 2256684
Spitz nevus (large spindle cell and/or epithelioid cell nevus). Age-related involvement of the suprabasal epidermis.
Mérot Y, Frenk E
Virchows Arch A Pathol Anat Histopathol 1989;415(2):97-101. doi: 10.1007/BF00784346. PMID: 2500774

Diagnosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Spitz nevus arising in the eyelid of a teenager.
Shields PW, Jakobiec FA, Stagner AM, Yoon MK
Surv Ophthalmol 2016 Mar-Apr;61(2):228-35. Epub 2015 Oct 22 doi: 10.1016/j.survophthal.2015.10.002. PMID: 26498574
Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy.
Kaye VN, Dehner LP
Arch Dermatol 1990 Dec;126(12):1581-3. PMID: 2256684
Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus).
Smith KJ, Barrett TL, Skelton HG 3rd, Lupton GP, Graham JH
Am J Surg Pathol 1989 Nov;13(11):931-9. doi: 10.1097/00000478-198911000-00003. PMID: 2802011
Nevus of large spindle and/or epithelioid cells (Spitz's nevus).
Paniago-Pereira C, Maize JC, Ackerman AB
Arch Dermatol 1978 Dec;114(12):1811-23. PMID: 367281

Prognosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
"Malignant Spitz nevus" in a 2-year-old Japanese child.
Nitta Y, Ohkochi Y, Hara K
J Dermatol 1995 Jul;22(7):500-3. doi: 10.1111/j.1346-8138.1995.tb03432.x. PMID: 7560441
Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy.
Kaye VN, Dehner LP
Arch Dermatol 1990 Dec;126(12):1581-3. PMID: 2256684

Clinical prediction guides

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Epithelioid melanocytic nevus with tubule and pseudoacini formation.
Uhlenhake EE, Smoller BR, Gardner JM, Shalin SC
J Cutan Pathol 2015 Mar;42(3):213-216. Epub 2014 Dec 23 doi: 10.1111/cup.12451. PMID: 25407962
Hyalinizing Spitz nevus: spindle and epithelioid cell nevus with paucicellular collagenous stroma.
Liu J, Cohen PR, Farhood A
South Med J 2004 Jan;97(1):102-6. doi: 10.1097/01.SMJ.0000055103.97445.AB. PMID: 14746435
Spindle and epithelioid cell nevus (Spitz nevus). Observation on nine cases.
Rădulescu D
Rom J Morphol Embryol 1994 Jan-Jun;40(1-2):15-8. PMID: 7640369
Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases.
Sau P, Graham JH, Helwig EB
J Am Acad Dermatol 1993 Apr;28(4):565-71. doi: 10.1016/0190-9622(93)70075-5. PMID: 8463457

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