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Paranasal Sinus Polyp

MedGen UID:
75536
•Concept ID:
C0264231
•
Neoplastic Process
Synonyms: Accessory Sinus Polyp; Nasal sinus polyp; Polyp of accessory sinus; Polyp of Accessory Sinus; Polyp of nasal sinus; Polyp of Paranasal Sinus; Polyp of the Accessory Sinus; Polyp of the Paranasal Sinus
SNOMED CT: Nasal sinus polyp (32307003); Polyp of nasal sinus (32307003); Polyp of accessory sinus (32307003)

Definition

A polyp that arises from the paranasal sinus mucosa. Causes include allergic rhinitis, chronic sinusitis, and cystic fibrosis. It is characterized by the presence of edematous tissue infiltrated by inflammatory cells, including eosinophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanasal Sinus Polyp

Professional guidelines

PubMed

Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions.
Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
Chapurin N, Wu J, Labby AB, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2022 Jul;150(1):22-32. Epub 2022 Apr 22 doi: 10.1016/j.jaci.2022.04.013. PMID: 35469844Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

Pediatric Versus Adult Chronic Rhinosinusitis.
Snidvongs K, Sangubol M, Poachanukoon O
Curr Allergy Asthma Rep 2020 Jun 6;20(8):29. doi: 10.1007/s11882-020-00924-6. PMID: 32506185
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Nasal Cavity and Paranasal Sinus Diseases Affecting Orbit.
Samil KS, Yasar C, Ercan A, Hanifi B, Hilal K
J Craniofac Surg 2015 Jun;26(4):e348-51. doi: 10.1097/SCS.0000000000001827. PMID: 26080260
Modification of the Lund-Kennedy endoscopic scoring system improves its reliability and correlation with patient-reported outcome measures.
Psaltis AJ, Li G, Vaezeafshar R, Cho KS, Hwang PH
Laryngoscope 2014 Oct;124(10):2216-23. Epub 2014 Apr 2 doi: 10.1002/lary.24654. PMID: 24615873
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

Diagnosis

Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
Chronic nasal dysfunction.
Jankowski R, Nguyen DT, Russel A, Toussaint B, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1):41-49. Epub 2017 Dec 14 doi: 10.1016/j.anorl.2017.11.006. PMID: 29249643
Revision Functional Endoscopic Sinus Surgery.
Levine CG, Casiano RR
Otolaryngol Clin North Am 2017 Feb;50(1):143-164. doi: 10.1016/j.otc.2016.08.012. PMID: 27888911
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2016 Jun;6(6):555-6. doi: 10.1002/alr.21806. PMID: 27342395

Therapy

Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Allergic fungal rhinosinusitis.
Dykewicz MS, Rodrigues JM, Slavin RG
J Allergy Clin Immunol 2018 Aug;142(2):341-351. doi: 10.1016/j.jaci.2018.06.023. PMID: 30080526
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2016 Jun;6(6):555-6. doi: 10.1002/alr.21806. PMID: 27342395
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Prognosis

Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions.
Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Chapter 7: Nasal polyps.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:22-23. doi: 10.2500/aap.2012.33.3537. PMID: 22794680
Mycotic sinusitis.
Eloy P, Bertrand B, Rombeaux P, Delos M, Trigaux JP
Acta Otorhinolaryngol Belg 1997;51(4):339-52. PMID: 9444380

Clinical prediction guides

Exhalation Delivery Systems for Application of Intranasal Corticosteroids.
Kovacs AJ, Adappa ND, Kuan EC
Ear Nose Throat J 2021 Jun;100(5):309-313. Epub 2020 Dec 11 doi: 10.1177/0145561320980194. PMID: 33305974
Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps.
Avdeeva K, Fokkens W
Curr Allergy Asthma Rep 2018 Mar 24;18(4):25. doi: 10.1007/s11882-018-0776-8. PMID: 29574586Free PMC Article
Olfaction in Endoscopic Sinus and Skull Base Surgery.
Thompson CF, Kern RC, Conley DB
Otolaryngol Clin North Am 2015 Oct;48(5):795-804. Epub 2015 Jun 24 doi: 10.1016/j.otc.2015.05.007. PMID: 26117298
Modification of the Lund-Kennedy endoscopic scoring system improves its reliability and correlation with patient-reported outcome measures.
Psaltis AJ, Li G, Vaezeafshar R, Cho KS, Hwang PH
Laryngoscope 2014 Oct;124(10):2216-23. Epub 2014 Apr 2 doi: 10.1002/lary.24654. PMID: 24615873
Chapter 7: Nasal polyps.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:22-23. doi: 10.2500/aap.2012.33.3537. PMID: 22794680

Recent systematic reviews

Chronic rhinosinusitis with nasal polyps (CRSwNP) treated with omalizumab, dupilumab, or mepolizumab: A systematic review of the current knowledge towards an attempt to compare agents' efficacy.
Papacharalampous GX, Constantinidis J, Fotiadis G, Zhang N, Bachert C, Katotomichelakis M
Int Forum Allergy Rhinol 2024 Jan;14(1):96-109. Epub 2023 Jul 18 doi: 10.1002/alr.23234. PMID: 37394893
Isolated sphenoid sinus opacifications: a systematic review and meta-analysis.
Moss WJ, Finegersh A, Jafari A, Panuganti B, Coffey CS, DeConde A, Husseman J
Int Forum Allergy Rhinol 2017 Dec;7(12):1201-1206. Epub 2017 Oct 12 doi: 10.1002/alr.22023. PMID: 29024448
Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.
Lal D, Jategaonkar AA, Borish L, Chambliss LR, Gnagi SH, Hwang PH, Rank MA, Stankiewicz JA, Lund VJ
Rhinology 2016 Jun;54(2):99-104. doi: 10.4193/Rhino15.228. PMID: 26800862Free PMC Article
Post-sinus surgery insertion of steroid-eluting bioabsorbable intranasal devices: A systematic review.
Rizan C, Elhassan HA
Laryngoscope 2016 Jan;126(1):86-92. Epub 2015 Jul 7 doi: 10.1002/lary.25460. PMID: 26154025
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

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