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Orbital lymphoma

MedGen UID:
75744
•Concept ID:
C0271333
•
Neoplastic Process
Synonyms: Lymphoma of the orbit; Orbit lymphoma; Primary orbital lymphoma
SNOMED CT: Orbital lymphoma (13048006)
 
Monarch Initiative: MONDO:0004942

Definition

A lymphoma that arises from the structures of the orbit. Representative examples include mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbital lymphoma

Professional guidelines

PubMed

Subconjunctival Orbital Fat Prolapse: An Update on Diagnosis and Management.
Secondi R, Sánchez España JC, Castellar Cerpa J, Ibáñez Flores N
Semin Ophthalmol 2019;34(2):69-73. Epub 2019 Feb 9 doi: 10.1080/08820538.2019.1576743. PMID: 30741060
Orbital lymphoma: diagnostic approach and treatment outcome.
Eckardt AM, Lemound J, Rana M, Gellrich NC
World J Surg Oncol 2013 Mar 18;11:73. doi: 10.1186/1477-7819-11-73. PMID: 23506357Free PMC Article
Orbital lymphoma treatment.
Ahmad S, Nutting CM, Plowman PN
Radiother Oncol 2001 Oct;61(1):101. doi: 10.1016/s0167-8140(01)00423-6. PMID: 11695339

Recent clinical studies

Etiology

Paediatric orbital lymphoma; a case series and review of the literature.
Keren S, Lapira M, McCallum E, Sipkova Z, Qureshi A, Wilson S, Norris JH, Hildebrand GD
Eye (Lond) 2023 Apr;37(5):1002-1008. Epub 2022 Sep 28 doi: 10.1038/s41433-022-02266-1. PMID: 36171296Free PMC Article
Epidemiology, outcomes, and prognostic factors of orbital lymphoma in the United States.
Ahmed OM, Ma AK, Ahmed TM, Pointdujour-Lim R
Orbit 2020 Dec;39(6):397-402. Epub 2020 Jan 2 doi: 10.1080/01676830.2019.1704032. PMID: 31894706
Orbital Lymphoma-An International Multicenter Retrospective Study.
Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2019 Mar;199:44-57. Epub 2018 Nov 10 doi: 10.1016/j.ajo.2018.11.002. PMID: 30419193
Orbital lymphomas: clinical and radiological features.
Gerbino G, Boffano P, Benech R, Baietto F, Gallesio C, Arcuri F, Benech A
J Craniomaxillofac Surg 2014 Jul;42(5):508-12. Epub 2013 Aug 27 doi: 10.1016/j.jcms.2013.07.017. PMID: 24051193
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma.
Woolf DK, Ahmed M, Plowman PN
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):339-44. Epub 2012 Apr 20 doi: 10.1016/j.clon.2012.03.001. PMID: 22521959

Diagnosis

Paediatric orbital lymphoma; a case series and review of the literature.
Keren S, Lapira M, McCallum E, Sipkova Z, Qureshi A, Wilson S, Norris JH, Hildebrand GD
Eye (Lond) 2023 Apr;37(5):1002-1008. Epub 2022 Sep 28 doi: 10.1038/s41433-022-02266-1. PMID: 36171296Free PMC Article
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Recent Advances in Orbital Tumors--A Review of Publications from 2014-2016.
Honavar SG, Manjandavida FP
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):153-158. doi: 10.22608/APO.201736. PMID: 28399335
Natural Killer T-Cell Lymphoma of the Orbit: An Evidence-Based Approach.
Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
Uveitis masquerade syndrome and orbital lymphoma: two challenging diagnosis.
Guex-Crosier Y
Klin Monbl Augenheilkd 2014 Apr;231(4):303. Epub 2014 Apr 25 doi: 10.1055/s-0034-1368272. PMID: 24771150

Therapy

Orbital Lymphoma-An International Multicenter Retrospective Study.
Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2019 Mar;199:44-57. Epub 2018 Nov 10 doi: 10.1016/j.ajo.2018.11.002. PMID: 30419193
Orbital mantle cell lymphoma presenting as myasthenia gravis.
Karlin J, Peck T, Prenshaw K, Portell CA, Kirzhner M
Orbit 2017 Dec;36(6):365-369. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337202. PMID: 28820310
Natural Killer T-Cell Lymphoma of the Orbit: An Evidence-Based Approach.
Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma.
Woolf DK, Ahmed M, Plowman PN
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):339-44. Epub 2012 Apr 20 doi: 10.1016/j.clon.2012.03.001. PMID: 22521959
Orbital lymphoma: role of radiation.
Yadav BS, Sharma SC
Indian J Ophthalmol 2009 Mar-Apr;57(2):91-7. doi: 10.4103/0301-4738.44516. PMID: 19237780Free PMC Article

Prognosis

Orbital Lymphoma-An International Multicenter Retrospective Study.
Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2019 Mar;199:44-57. Epub 2018 Nov 10 doi: 10.1016/j.ajo.2018.11.002. PMID: 30419193
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Natural Killer T-Cell Lymphoma of the Orbit: An Evidence-Based Approach.
Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
Orbital lymphomas: clinical and radiological features.
Gerbino G, Boffano P, Benech R, Baietto F, Gallesio C, Arcuri F, Benech A
J Craniomaxillofac Surg 2014 Jul;42(5):508-12. Epub 2013 Aug 27 doi: 10.1016/j.jcms.2013.07.017. PMID: 24051193
Orbital lymphoma: role of radiation.
Yadav BS, Sharma SC
Indian J Ophthalmol 2009 Mar-Apr;57(2):91-7. doi: 10.4103/0301-4738.44516. PMID: 19237780Free PMC Article

Clinical prediction guides

Long-Term Clinical Outcomes and Sequelae of Therapy in Early-Stage Orbital Mucosa-Associated Lymphoid Tissue Lymphoma.
Panda G, Kalra B, Rishi A, Khanna N, Kakoti S, Sridhar E, Shet T, Sengar M, Nayak L, Bagal B, Jain H, Laskar SS, Goda JS
Clin Lymphoma Myeloma Leuk 2022 Jul;22(7):513-522. Epub 2021 Dec 25 doi: 10.1016/j.clml.2021.12.013. PMID: 35027338
Epidemiology, outcomes, and prognostic factors of orbital lymphoma in the United States.
Ahmed OM, Ma AK, Ahmed TM, Pointdujour-Lim R
Orbit 2020 Dec;39(6):397-402. Epub 2020 Jan 2 doi: 10.1080/01676830.2019.1704032. PMID: 31894706
Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis.
Marinò M, Ionni I, Lanzolla G, Sframeli A, Latrofa F, Rocchi R, Marcocci C
J Endocrinol Invest 2020 Apr;43(4):401-411. Epub 2019 Nov 5 doi: 10.1007/s40618-019-01141-3. PMID: 31691261
Orbital Lymphoma-An International Multicenter Retrospective Study.
Olsen TG, Holm F, Mikkelsen LH, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Sjö LD, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2019 Mar;199:44-57. Epub 2018 Nov 10 doi: 10.1016/j.ajo.2018.11.002. PMID: 30419193
Orbital mantle cell lymphoma presenting as myasthenia gravis.
Karlin J, Peck T, Prenshaw K, Portell CA, Kirzhner M
Orbit 2017 Dec;36(6):365-369. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337202. PMID: 28820310

Recent systematic reviews

Diffusion-Weighted Imaging of the Orbit: A Case Series and Systematic Review.
Gupta L, Peterson EL, Williams C, Altman E, Harpole R, Martin DJ, Escott EJ, Timoney PJ, Prendes MA
Ophthalmic Plast Reconstr Surg 2023 Sep-Oct 01;39(5):407-418. Epub 2023 Feb 9 doi: 10.1097/IOP.0000000000002325. PMID: 36757844
Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review.
Cameron CA, Tong JY, Juniat V, Patel S, Selva D
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):515-521. doi: 10.1097/IOP.0000000000002092. PMID: 34798654
Subconjunctival Orbital Fat Prolapse: An Update on Diagnosis and Management.
Secondi R, Sánchez España JC, Castellar Cerpa J, Ibáñez Flores N
Semin Ophthalmol 2019;34(2):69-73. Epub 2019 Feb 9 doi: 10.1080/08820538.2019.1576743. PMID: 30741060

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