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Recurrent Childhood Lymphoblastic Lymphoma

MedGen UID:
75864
•Concept ID:
C0278739
•
Neoplastic Process
Synonyms: Recurrent Childhood Precursor Lymphoblastic Lymphoma; Recurrent Pediatric Lymphoblastic Lymphoma; Relapsed Childhood Lymphoblastic Lymphoma; Relapsed Pediatric Lymphoblastic Lymphoma

Definition

The reemergence of lymphoblastic lymphoma in childhood after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Lymphoblastic Lymphoma

Professional guidelines

PubMed

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia.
Ryan SL, Peden JF, Kingsbury Z, Schwab CJ, James T, Polonen P, Mijuskovic M, Becq J, Yim R, Cranston RE, Hedges DJ, Roberts KG, Mullighan CG, Vora A, Russell LJ, Bain R, Moorman AV, Bentley DR, Harrison CJ, Ross MT
Leukemia 2023 Mar;37(3):518-528. Epub 2023 Jan 19 doi: 10.1038/s41375-022-01806-8. PMID: 36658389Free PMC Article
Targeted Treatment and Immunotherapy in High-risk and Relapsed/ Refractory Pediatric Acute Lymphoblastic Leukemia.
Graiqevci-Uka V, Behluli E, Spahiu L, Liehr T, Temaj G
Curr Pediatr Rev 2023;19(2):150-156. doi: 10.2174/1573396318666220901165247. PMID: 36056858Free PMC Article
Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium.
Buchmann S, Schrappe M, Baruchel A, Biondi A, Borowitz M, Campbell M, Cario G, Cazzaniga G, Escherich G, Harrison CJ, Heyman M, Hunger SP, Kiss C, Liu HC, Locatelli F, Loh ML, Manabe A, Mann G, Pieters R, Pui CH, Rives S, Schmiegelow K, Silverman LB, Stary J, Vora A, Brown P
Blood 2022 Mar 24;139(12):1785-1793. doi: 10.1182/blood.2021012328. PMID: 34192312Free PMC Article

Recent clinical studies

Etiology

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia.
Pulsipher MA, Han X, Maude SL, Laetsch TW, Qayed M, Rives S, Boyer MW, Hiramatsu H, Yanik GA, Driscoll T, Myers GD, Bader P, Baruchel A, Buechner J, Stefanski HE, Kalfoglou C, Nguyen K, Waldron ER, Thudium Mueller K, Maier HJ, Kari G, Grupp SA
Blood Cancer Discov 2022 Jan;3(1):66-81. Epub 2021 Dec 1 doi: 10.1158/2643-3230.BCD-21-0095. PMID: 35019853Free PMC Article
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089

Diagnosis

Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia.
Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ, Zhu X, Liu X
Blood 2018 May 17;131(20):2256-2261. Epub 2018 Feb 6 doi: 10.1182/blood-2017-11-817510. PMID: 29434033Free PMC Article
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article

Therapy

Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article
PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia.
Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ, Zhu X, Liu X
Blood 2018 May 17;131(20):2256-2261. Epub 2018 Feb 6 doi: 10.1182/blood-2017-11-817510. PMID: 29434033Free PMC Article
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089

Prognosis

Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089

Clinical prediction guides

Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia.
Pulsipher MA, Han X, Maude SL, Laetsch TW, Qayed M, Rives S, Boyer MW, Hiramatsu H, Yanik GA, Driscoll T, Myers GD, Bader P, Baruchel A, Buechner J, Stefanski HE, Kalfoglou C, Nguyen K, Waldron ER, Thudium Mueller K, Maier HJ, Kari G, Grupp SA
Blood Cancer Discov 2022 Jan;3(1):66-81. Epub 2021 Dec 1 doi: 10.1158/2643-3230.BCD-21-0095. PMID: 35019853Free PMC Article
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089

Recent systematic reviews

PEG-asparaginase treatment regimens for acute lymphoblastic leukaemia in children: a network meta-analysis.
Lynggaard LS, Rank CU, Als-Nielsen B, Hoejfeldt SG, Heyman M, Schmiegelow K, Albertsen BK
Cochrane Database Syst Rev 2023 May 31;5(5):CD014570. doi: 10.1002/14651858.CD014570.pub2. PMID: 37260073Free PMC Article
How much asparaginase is needed for optimal outcome in childhood acute lymphoblastic leukaemia? A systematic review.
Brigitha LJ, Pieters R, van der Sluis IM
Eur J Cancer 2021 Nov;157:238-249. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.025. PMID: 34536947
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914

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