Pulmonary non-tuberculous mycobacterial infection

MedGen UID:: 758704
•Concept ID:: C3472679
•: Disease or Syndrome

Synonyms:	Atypical mycobacterial infection of lung; Non-tuberculous mycobacterial lung disease; non-tuberculous mycobacterial lung disease; Nontuberculous mycobacterial lung disease; nontuberculous mycobacterial lung disease; Nontuberculous Mycobacterial Lung Disease; pulmonary non-tuberculous mycobacterial infection
SNOMED CT:	Atypical mycobacterial infection of lung (1731000119106); Nontuberculous mycobacterial lung disease (1731000119106)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0018469
Orphanet:	ORPHA411703

Definition

A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including Mycobacterium avium complex, Mycobacterium kansasii, or Mycobacterium xenopi, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities. [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPulmonary non-tuberculous mycobacterial infection

Disease, Respiratory Tract
- Disorder of lung
  - Pulmonary non-tuberculous mycobacterial infection

Professional guidelines

PubMed

Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643 Free PMC Article

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Recent clinical studies

Etiology

Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.

Flume PA, Garcia BA, Wilson D, Steed L, Dorman SE, Winthrop K
Respir Med 2023 Jan;206:107069. Epub 2022 Dec 2 doi: 10.1016/j.rmed.2022.107069. PMID: 36493605

The antimicrobial susceptibility of non-tuberculous mycobacteria.

Cowman S, Burns K, Benson S, Wilson R, Loebinger MR
J Infect 2016 Mar;72(3):324-31. Epub 2015 Dec 24 doi: 10.1016/j.jinf.2015.12.007. PMID: 26723913

CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients.

Lee Y, Song JW, Chae EJ, Lee HJ, Lee CW, Do KH, Seo JB, Kim MY, Lee JS, Song KS, Shim TS
Br J Radiol 2013 Apr;86(1024):20120209. Epub 2013 Feb 25 doi: 10.1259/bjr.20120209. PMID: 23440166 Free PMC Article

Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643 Free PMC Article

See all (4)

Diagnosis

Multiple Postoperative Lung Infections after Thymoma Surgery Diagnosed as Nontuberculous Mycobacterial Infection.

Nie CX, Zhang JB, Ji HL, Li XR, Luo JF, Fu AS, Ge YL, Liu TJ, Chen T
Clin Lab 2024 Aug 1;70(8) doi: 10.7754/Clin.Lab.2024.240315. PMID: 39193971

Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.

Setoguchi D, Iwanaga N, Ito Y, Ashizawa N, Hirayama T, Takeda K, Ide S, Takemoto S, Tashiro M, Hosogaya N, Takazono T, Sakamoto N, Obase Y, Izumikawa K, Yanagihara K, Mukae H
J Infect Chemother 2023 Jun;29(6):615-619. Epub 2023 Mar 13 doi: 10.1016/j.jiac.2023.03.010. PMID: 36921763

The antimicrobial susceptibility of non-tuberculous mycobacteria.

Cowman S, Burns K, Benson S, Wilson R, Loebinger MR
J Infect 2016 Mar;72(3):324-31. Epub 2015 Dec 24 doi: 10.1016/j.jinf.2015.12.007. PMID: 26723913

CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients.

Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643 Free PMC Article

See all (6)

Therapy

Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.

Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.

Flume PA, Garcia BA, Wilson D, Steed L, Dorman SE, Winthrop K
Respir Med 2023 Jan;206:107069. Epub 2022 Dec 2 doi: 10.1016/j.rmed.2022.107069. PMID: 36493605

Pharmacokinetics and Adverse Effects of Clofazimine in the Treatment of Pulmonary Non-Tuberculous Mycobacterial Infection.

Watanabe F, Furuuchi K, Hanada K, Fujiwara K, Uesugi F, Hiramatsu M, Yoshiyama T, Shiraishi Y, Kurashima A, Ohta K, Morimoto K
Antimicrob Agents Chemother 2022 Aug 16;66(8):e0044122. Epub 2022 Jul 7 doi: 10.1128/aac.00441-22. PMID: 35862744 Free PMC Article

Endobronchial carcinoid tumor combined with pulmonary non-tuberculous mycobacterial infection: report of two cases.

Nakamura Y, Okada Y, Endo C, Aikawa H, Sakurada A, Sato M, Kondo T
Lung Cancer 2003 Feb;39(2):227-9. doi: 10.1016/s0169-5002(02)00450-6. PMID: 12581578

Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Al Jarad N, Demertzis P, Jones DJ, Barnes NC, Rudd RM, Gaya H, Wedzicha JA, Hughes DT, Empey DW
Thorax 1996 Feb;51(2):137-9. doi: 10.1136/thx.51.2.137. PMID: 8711643 Free PMC Article

See all (5)