U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ocular melanoma with extraocular extension

MedGen UID:
75884
•Concept ID:
C0278869
•
Neoplastic Process
Synonyms: Extraocular Extension Melanoma; extraocular extension melanoma; Extraocular Extension of Melanoma; extraocular extension of melanoma; Ocular Melanoma with Extraocular Extension; ocular melanoma with extraocular extension
 
Monarch Initiative: MONDO:0006326

Definition

A melanoma arising from and extending beyond the structures of the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular melanoma with extraocular extension

Professional guidelines

PubMed

Delays between Uveal Melanoma Diagnosis and Treatment Increase the Risk of Metastatic Death.
Stålhammar G
Ophthalmology 2024 Sep;131(9):1094-1104. Epub 2023 Nov 21 doi: 10.1016/j.ophtha.2023.11.021. PMID: 37995852
Diagnosis and treatment of orbital invasion in uveal melanoma.
Blanco G
Can J Ophthalmol 2004 Jun;39(4):388-96. doi: 10.1016/s0008-4182(04)80010-3. PMID: 15327104
Current management of posterior uveal melanoma.
Shields JA, Shields CL
Mayo Clin Proc 1993 Dec;68(12):1196-200. doi: 10.1016/s0025-6196(12)60072-x. PMID: 8246622

Recent clinical studies

Etiology

A comprehensive review of PRAME and BAP1 in melanoma: Genomic instability and immunotherapy targets.
Aljabali AAA, Tambuwala MM, El-Tanani M, Hassan SS, Lundstrom K, Mishra V, Mishra Y, Hromić-Jahjefendić A, Redwan EM, Uversky VN
Cell Signal 2024 Dec;124:111434. Epub 2024 Sep 24 doi: 10.1016/j.cellsig.2024.111434. PMID: 39326690
Identification of extraocular extension in uveal melanoma by ophthalmological ultrasound.
Stael Apolo JA, Conde I, Fernández D, Fernández S, Bande M, Pardo M, Ruiz-Oliva F, Blanco MJ, Piñeiro A
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):70-76. Epub 2021 Dec 24 doi: 10.1016/j.oftale.2021.02.004. PMID: 35152951
Prognosis of uveal melanoma based on race in 8100 patients: The 2015 Doyne Lecture.
Shields CL, Kaliki S, Cohen MN, Shields PW, Furuta M, Shields JA
Eye (Lond) 2015 Aug;29(8):1027-35. Epub 2015 Aug 7 doi: 10.1038/eye.2015.51. PMID: 26248525Free PMC Article
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659

Diagnosis

Cavitary ciliochoroidal melanoma with extraocular extension.
Anguita R, Thaung C, Sagoo MS
Can J Ophthalmol 2024 Feb;59(1):e83. Epub 2023 Oct 17 doi: 10.1016/j.jcjo.2023.09.008. PMID: 37863107
Identification of extraocular extension in uveal melanoma by ophthalmological ultrasound.
Stael Apolo JA, Conde I, Fernández D, Fernández S, Bande M, Pardo M, Ruiz-Oliva F, Blanco MJ, Piñeiro A
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):70-76. Epub 2021 Dec 24 doi: 10.1016/j.oftale.2021.02.004. PMID: 35152951
Massive Extraocular Extension of Uveal Melanoma.
Greenberg EL, Cox KF, Margo CE, Leyngold IM
Ophthalmic Plast Reconstr Surg 2016 Nov/Dec;32(6):e166. doi: 10.1097/IOP.0000000000000691. PMID: 27097065
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Therapy

Combined photodynamic therapy and transpupillary thermotherapy for small choroidal melanoma.
Rolfe OJ, Stark AL, Hamilton HR, D'Mellow M, Palmer JM, McGrath LA, Warrier SK, Glasson WJ
Can J Ophthalmol 2024 Dec;59(6):409-416. Epub 2024 Feb 29 doi: 10.1016/j.jcjo.2024.02.001. PMID: 38431268
Scleral necrosis after brachytherapy for uveal melanoma: Analysis of risk factors.
Jabbarli L, Guberina M, Biewald E, Flühs D, Guberina N, Le Guin CHD, Sauerwein W, Bornfeld N, Stuschke M, Bechrakis NE
Clin Exp Ophthalmol 2021 May;49(4):357-367. Epub 2021 May 4 doi: 10.1111/ceo.13928. PMID: 33866652
Staging of ciliary body and choroidal melanomas based on anatomic extent.
Kujala E, Damato B, Coupland SE, Desjardins L, Bechrakis NE, Grange JD, Kivelä T
J Clin Oncol 2013 Aug 1;31(22):2825-31. Epub 2013 Jul 1 doi: 10.1200/JCO.2012.45.2771. PMID: 23816968
Uveal melanoma: management and outcome of patients with extraocular spread.
Bellmann C, Lumbroso-Le Rouic L, Levy C, Plancher C, Dendale R, Sastre-Garau X, Asselain B, Desjardins L
Br J Ophthalmol 2010 May;94(5):569-74. Epub 2009 Dec 3 doi: 10.1136/bjo.2009.165423. PMID: 19965816
Current management of posterior uveal melanoma.
Shields JA, Shields CL
Mayo Clin Proc 1993 Dec;68(12):1196-200. doi: 10.1016/s0025-6196(12)60072-x. PMID: 8246622

Prognosis

A comprehensive review of PRAME and BAP1 in melanoma: Genomic instability and immunotherapy targets.
Aljabali AAA, Tambuwala MM, El-Tanani M, Hassan SS, Lundstrom K, Mishra V, Mishra Y, Hromić-Jahjefendić A, Redwan EM, Uversky VN
Cell Signal 2024 Dec;124:111434. Epub 2024 Sep 24 doi: 10.1016/j.cellsig.2024.111434. PMID: 39326690
Identification of extraocular extension in uveal melanoma by ophthalmological ultrasound.
Stael Apolo JA, Conde I, Fernández D, Fernández S, Bande M, Pardo M, Ruiz-Oliva F, Blanco MJ, Piñeiro A
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):70-76. Epub 2021 Dec 24 doi: 10.1016/j.oftale.2021.02.004. PMID: 35152951
Prognosis of uveal melanoma based on race in 8100 patients: The 2015 Doyne Lecture.
Shields CL, Kaliki S, Cohen MN, Shields PW, Furuta M, Shields JA
Eye (Lond) 2015 Aug;29(8):1027-35. Epub 2015 Aug 7 doi: 10.1038/eye.2015.51. PMID: 26248525Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Intraocular schwannoma.
You JY, Finger PT, Iacob C, McCormick SA, Milman T
Surv Ophthalmol 2013 Jan-Feb;58(1):77-85. Epub 2012 Sep 14 doi: 10.1016/j.survophthal.2012.04.003. PMID: 22981398

Clinical prediction guides

Association Between Uveal Melanoma and Allostatic Load.
Sureshkumar H, Eathara A, Datta A, Alahmadi R, Nguyen RH, Heiferman MJ
Anticancer Res 2024 Aug;44(8):3375-3380. doi: 10.21873/anticanres.17158. PMID: 39060061
Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659
Uveal melanoma: management and outcome of patients with extraocular spread.
Bellmann C, Lumbroso-Le Rouic L, Levy C, Plancher C, Dendale R, Sastre-Garau X, Asselain B, Desjardins L
Br J Ophthalmol 2010 May;94(5):569-74. Epub 2009 Dec 3 doi: 10.1136/bjo.2009.165423. PMID: 19965816

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...