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T-cell childhood acute lymphocytic leukemia

MedGen UID:
75996
•Concept ID:
C0279583
•
Neoplastic Process
Synonyms: childhood precursor T-lymphoblastic leukaemia; Childhood Precursor T-Lymphoblastic Leukemia; childhood precursor T-lymphoblastic leukemia; childhood T acute lymphoblastic leukaemia; Childhood T Acute Lymphoblastic Leukemia; childhood T acute lymphoblastic leukemia; Childhood T-Acute Lymphoblastic Leukemia; childhood T-ALL; childhood T-cell acute lymphoblastic leukaemia; Childhood T-Cell Acute Lymphoblastic Leukemia; childhood T-cell acute lymphoblastic leukemia; T-cell childhood acute lymphoblastic leukaemia; T-Cell Childhood Acute Lymphoblastic Leukemia; T-cell childhood acute lymphoblastic leukemia; T-Cell Childhood ALL; T-cell childhood ALL; T-cell paediatric acute lymphoblastic leukaemia; T-cell paediatric acute lymphocytic leukaemia; T-cell paediatric ALL; T-Cell Pediatric Acute Lymphoblastic Leukemia; T-cell pediatric acute lymphoblastic leukemia; T-cell pediatric acute lymphocytic leukemia; T-Cell Pediatric ALL; T-cell pediatric ALL
 
Monarch Initiative: MONDO:0000871

Definition

An acute lymphoblastic leukemia of T-cell origin occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell childhood acute lymphocytic leukemia

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Śliwa-Tytko P, Kaczmarska A, Lejman M, Zawitkowska J
Int J Mol Sci 2022 May 15;23(10) doi: 10.3390/ijms23105515. PMID: 35628334Free PMC Article
Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management.
Rausch CR, Jabbour EJ, Kantarjian HM, Kadia TM
Cancer 2020 Mar 15;126(6):1152-1160. Epub 2019 Dec 3 doi: 10.1002/cncr.32606. PMID: 31794095

Recent clinical studies

Etiology

Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Precision medicine in acute lymphoblastic leukemia.
Pui CH
Front Med 2020 Dec;14(6):689-700. Epub 2020 Oct 19 doi: 10.1007/s11684-020-0759-8. PMID: 33074527Free PMC Article
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article

Diagnosis

How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.
Kruse A, Abdel-Azim N, Kim HN, Ruan Y, Phan V, Ogana H, Wang W, Lee R, Gang EJ, Khazal S, Kim YM
Int J Mol Sci 2020 Feb 5;21(3) doi: 10.3390/ijms21031054. PMID: 32033444Free PMC Article

Therapy

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.
Amini L, Silbert SK, Maude SL, Nastoupil LJ, Ramos CA, Brentjens RJ, Sauter CS, Shah NN, Abou-El-Enein M
Nat Rev Clin Oncol 2022 May;19(5):342-355. Epub 2022 Mar 22 doi: 10.1038/s41571-022-00607-3. PMID: 35318469
Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma.
Teachey DT, Devidas M, Wood BL, Chen Z, Hayashi RJ, Hermiston ML, Annett RD, Archer JH, Asselin BL, August KJ, Cho SY, Dunsmore KP, Fisher BT, Freedman JL, Galardy PJ, Harker-Murray P, Horton TM, Jaju AI, Lam A, Messinger YH, Miles RR, Okada M, Patel SI, Schafer ES, Schechter T, Singh N, Steele AC, Sulis ML, Vargas SL, Winter SS, Wood C, Zweidler-McKay P, Bollard CM, Loh ML, Hunger SP, Raetz EA
J Clin Oncol 2022 Jul 1;40(19):2106-2118. Epub 2022 Mar 10 doi: 10.1200/JCO.21.02678. PMID: 35271306Free PMC Article
T cell-engaging therapies - BiTEs and beyond.
Goebeler ME, Bargou RC
Nat Rev Clin Oncol 2020 Jul;17(7):418-434. Epub 2020 Apr 2 doi: 10.1038/s41571-020-0347-5. PMID: 32242094
Immunotherapy in pediatric acute lymphoblastic leukemia.
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Mechanisms of resistance to CAR T cell therapy.
Shah NN, Fry TJ
Nat Rev Clin Oncol 2019 Jun;16(6):372-385. doi: 10.1038/s41571-019-0184-6. PMID: 30837712Free PMC Article

Prognosis

How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.
Amini L, Silbert SK, Maude SL, Nastoupil LJ, Ramos CA, Brentjens RJ, Sauter CS, Shah NN, Abou-El-Enein M
Nat Rev Clin Oncol 2022 May;19(5):342-355. Epub 2022 Mar 22 doi: 10.1038/s41571-022-00607-3. PMID: 35318469
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia.
Lato MW, Przysucha A, Grosman S, Zawitkowska J, Lejman M
Int J Mol Sci 2021 Apr 26;22(9) doi: 10.3390/ijms22094502. PMID: 33925883Free PMC Article
Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091Free PMC Article

Clinical prediction guides

MRD in ALL: Optimization and Innovations.
Pierce E, Mautner B, Mort J, Blewett A, Morris A, Keng M, El Chaer F
Curr Hematol Malig Rep 2022 Aug;17(4):69-81. Epub 2022 May 26 doi: 10.1007/s11899-022-00664-6. PMID: 35616771
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia.
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.
Kruse A, Abdel-Azim N, Kim HN, Ruan Y, Phan V, Ogana H, Wang W, Lee R, Gang EJ, Khazal S, Kim YM
Int J Mol Sci 2020 Feb 5;21(3) doi: 10.3390/ijms21031054. PMID: 32033444Free PMC Article
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Recent systematic reviews

Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis.
Willyanto SE, Alimsjah YA, Tanjaya K, Tuekprakhon A, Pawestri AR
Ann Med 2024 Dec;56(1):2349796. Epub 2024 May 13 doi: 10.1080/07853890.2024.2349796. PMID: 38738799Free PMC Article
Comparison of blinatumomab and CAR T-cell therapy in relapsed/refractory acute lymphoblastic leukemia: a systematic review and meta-analysis.
Zhai Y, Hong J, Wang J, Jiang Y, Wu W, Lv Y, Guo J, Tian L, Sun H, Li Y, Li C, Zhan H, Zhao Z
Expert Rev Hematol 2024 Jan-Mar;17(1-3):67-76. Epub 2024 Jan 4 doi: 10.1080/17474086.2023.2298732. PMID: 38135295
A systematic review and meta-analysis of CD22 CAR T-cells alone or in combination with CD19 CAR T-cells.
Fergusson NJ, Adeel K, Kekre N, Atkins H, Hay KA
Front Immunol 2023;14:1178403. Epub 2023 Apr 27 doi: 10.3389/fimmu.2023.1178403. PMID: 37180149Free PMC Article
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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