U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mixed cell type kidney Wilms tumor

MedGen UID:
76001
•Concept ID:
C0279611
•
Neoplastic Process
Synonym: Mixed cell type kidney Wilms' tumor
 
Monarch Initiative: MONDO:0003318

Definition

Wilms tumor of the kidney characterized by the presence of blastema, epithelial, and mesenchymal components (triphasic pattern) or a combination of two of them (biphasic pattern). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed cell type kidney Wilms tumor

Professional guidelines

PubMed

Perioperative management after high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell transplantation for pediatric solid tumors.
Uehara S, Oue T, Nakahata K, Nara K, Ueno T, Owari M, Usui N, Miyamura T, Hashii Y
Eur J Pediatr Surg 2015 Feb;25(1):118-22. Epub 2014 Aug 11 doi: 10.1055/s-0034-1386638. PMID: 25111275
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability.
Ma G, Gao A, Chen J, Liu P, Sarda R, Gulliver J, Wang Y, Joiner C, Hu M, Kim EJ, Yeger H, Le HD, Chen X, Li WJ, Xu W
Cell Rep Med 2024 Oct 15;5(10):101770. Epub 2024 Oct 4 doi: 10.1016/j.xcrm.2024.101770. PMID: 39368485Free PMC Article
Somatic-type Malignancies in Testicular Germ Cell Tumors: A Clinicopathologic Study of 63 Cases.
Hwang MJ, Hamza A, Zhang M, Tu SM, Pisters LL, Czerniak B, Guo CC
Am J Surg Pathol 2022 Jan 1;46(1):11-17. doi: 10.1097/PAS.0000000000001789. PMID: 34334690Free PMC Article
Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases.
Zaloudek CJ, Norris HJ
Cancer 1981 Jul 15;48(2):354-66. doi: 10.1002/1097-0142(19810715)48:2<354::aid-cncr2820480222>3.0.co;2-q. PMID: 6263458

Diagnosis

Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability.
Ma G, Gao A, Chen J, Liu P, Sarda R, Gulliver J, Wang Y, Joiner C, Hu M, Kim EJ, Yeger H, Le HD, Chen X, Li WJ, Xu W
Cell Rep Med 2024 Oct 15;5(10):101770. Epub 2024 Oct 4 doi: 10.1016/j.xcrm.2024.101770. PMID: 39368485Free PMC Article
Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum?
Argani P
Clin Lab Med 2005 Jun;25(2):379-92. doi: 10.1016/j.cll.2005.01.002. PMID: 15848742
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818
The evolution of the diagnosis and understanding of primitive and embryonic neoplasms in children: living through an epoch.
Dehner LP
Mod Pathol 1998 Jul;11(7):669-85. PMID: 9688189

Therapy

Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability.
Ma G, Gao A, Chen J, Liu P, Sarda R, Gulliver J, Wang Y, Joiner C, Hu M, Kim EJ, Yeger H, Le HD, Chen X, Li WJ, Xu W
Cell Rep Med 2024 Oct 15;5(10):101770. Epub 2024 Oct 4 doi: 10.1016/j.xcrm.2024.101770. PMID: 39368485Free PMC Article
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination.
Suwabe T, Shibasaki Y, Tamura S, Katagiri T, Fuse K, Ida-Kurasaki T, Ushiki T, Sone H, Narita M, Masuko M
Int J Hematol 2024 Apr;119(4):399-406. Epub 2024 Mar 1 doi: 10.1007/s12185-024-03723-1. PMID: 38427208
Role of Canagliflozin on function of CD34+ve endothelial progenitor cells (EPC) in patients with type 2 diabetes.
Nandula SR, Kundu N, Awal HB, Brichacek B, Fakhri M, Aimalla N, Elzarki A, Amdur RL, Sen S
Cardiovasc Diabetol 2021 Feb 13;20(1):44. doi: 10.1186/s12933-021-01235-4. PMID: 33581737Free PMC Article
Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.
Awal HB, Nandula SR, Domingues CC, Dore FJ, Kundu N, Brichacek B, Fakhri M, Elzarki A, Ahmadi N, Safai S, Fosso M, Amdur RL, Sen S
Cardiovasc Diabetol 2020 Jun 3;19(1):72. doi: 10.1186/s12933-020-01046-z. PMID: 32493344Free PMC Article
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Prognosis

CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor.
Xiang B, Chen ML, Gao ZQ, Mi T, Shi QL, Dong JJ, Tian XM, Liu F, Wei GH
BMC Med Genomics 2023 Aug 17;16(1):189. doi: 10.1186/s12920-023-01627-3. PMID: 37592341Free PMC Article
Somatic-type Malignancies in Testicular Germ Cell Tumors: A Clinicopathologic Study of 63 Cases.
Hwang MJ, Hamza A, Zhang M, Tu SM, Pisters LL, Czerniak B, Guo CC
Am J Surg Pathol 2022 Jan 1;46(1):11-17. doi: 10.1097/PAS.0000000000001789. PMID: 34334690Free PMC Article
Role of Canagliflozin on function of CD34+ve endothelial progenitor cells (EPC) in patients with type 2 diabetes.
Nandula SR, Kundu N, Awal HB, Brichacek B, Fakhri M, Aimalla N, Elzarki A, Amdur RL, Sen S
Cardiovasc Diabetol 2021 Feb 13;20(1):44. doi: 10.1186/s12933-021-01235-4. PMID: 33581737Free PMC Article
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases.
Zaloudek CJ, Norris HJ
Cancer 1981 Jul 15;48(2):354-66. doi: 10.1002/1097-0142(19810715)48:2<354::aid-cncr2820480222>3.0.co;2-q. PMID: 6263458

Clinical prediction guides

CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor.
Xiang B, Chen ML, Gao ZQ, Mi T, Shi QL, Dong JJ, Tian XM, Liu F, Wei GH
BMC Med Genomics 2023 Aug 17;16(1):189. doi: 10.1186/s12920-023-01627-3. PMID: 37592341Free PMC Article
Role of Canagliflozin on function of CD34+ve endothelial progenitor cells (EPC) in patients with type 2 diabetes.
Nandula SR, Kundu N, Awal HB, Brichacek B, Fakhri M, Aimalla N, Elzarki A, Amdur RL, Sen S
Cardiovasc Diabetol 2021 Feb 13;20(1):44. doi: 10.1186/s12933-021-01235-4. PMID: 33581737Free PMC Article
Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms.
Ohishi Y, Oda Y, Kurihara S, Kaku T, Yasunaga M, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M
Hum Pathol 2009 Aug;40(8):1168-75. Epub 2009 Apr 14 doi: 10.1016/j.humpath.2009.01.002. PMID: 19368953
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Yang Y, Niu ZB, Hou Y, Wang CL
J Pediatr Surg 2006 Jun;41(6):1062-6. doi: 10.1016/j.jpedsurg.2006.01.072. PMID: 16769335
Pathological relevance of epithelial and mesenchymal phenotype plasticity.
Guarino M, Micheli P, Pallotti F, Giordano F
Pathol Res Pract 1999;195(6):379-89. doi: 10.1016/S0344-0338(99)80011-9. PMID: 10399178

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...