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Colon Undifferentiated Carcinoma

MedGen UID:
76008
•Concept ID:
C0279643
•
Neoplastic Process
Synonyms: Carcinoma Simplex of the Colon.; Colon Anaplastic Carcinoma; Undifferentiated Carcinoma of Colon; Undifferentiated Carcinoma of the Colon; Undifferentiated Colonic Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the colon. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Undifferentiated Carcinoma

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4. Epub 2019 May 30 doi: 10.1053/j.gastro.2019.05.057. PMID: 31154022Free PMC Article
Evolving endoscopic strategies for detection and treatment of neoplastic lesions in inflammatory bowel disease.
Murthy SK, Kiesslich R
Gastrointest Endosc 2013 Mar;77(3):351-9. Epub 2013 Jan 12 doi: 10.1016/j.gie.2012.11.030. PMID: 23317581
Large bowel adenomas.
Fenoglio-Preiser CM, Sivak MV Jr, DeCosse JJ
CA Cancer J Clin 1989 Jul-Aug;39(4):219-25. doi: 10.3322/canjclin.39.4.219. PMID: 2503236

Diagnosis

Medullary carcinoma in the colon.
Kelly ML
ANZ J Surg 2023 Mar;93(3):710-711. Epub 2022 Jul 4 doi: 10.1111/ans.17901. PMID: 35789052
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Large bowel adenomas.
Fenoglio-Preiser CM, Sivak MV Jr, DeCosse JJ
CA Cancer J Clin 1989 Jul-Aug;39(4):219-25. doi: 10.3322/canjclin.39.4.219. PMID: 2503236

Therapy

Natural orifice specimen extraction surgery versus small-incision assisted laparoscopic radical right hemicolectomy.
Yu M, Cai Z, Zhou H, Fingerhut A, He Z, Xue P, Song H, Yang X, Cheng X, Zhang S, Xu X, Zhong H, Abuduaini N, Liu J, Wang X, Feng B
Future Oncol 2023 Dec;19(40):2641-2650. Epub 2023 Dec 18 doi: 10.2217/fon-2023-0769. PMID: 38108112
An Uncommon Cause of Hematochezia.
Ishtiaq R, Aziz M, Wilhelm DM, Gaduputi VV, Hamdani SU
J Gastrointest Cancer 2021 Mar;52(1):359-364. doi: 10.1007/s12029-020-00470-4. PMID: 32761320
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
A spangled colon.
Raghoo R, Laverman GD, Woittiez AJ, van den Hout JH, de Vries PA
Neth J Med 2012 Oct;70(8):376-80. PMID: 23065988
Esophagocoloplasty.
Gregorie HB Jr
Ann Surg 1972 May;175(5):740-51. doi: 10.1097/00000658-197205000-00014. PMID: 5028488Free PMC Article

Prognosis

Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction.
Romayor I, Márquez J, Benedicto A, Herrero A, Arteta B, Olaso E
Am J Physiol Gastrointest Liver Physiol 2021 Jun 1;320(6):G1002-G1013. Epub 2021 Apr 14 doi: 10.1152/ajpgi.00078.2021. PMID: 33851541
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Primary combined neuroendocrine carcinoma (small-cell type) and squamous cell carcinoma of the colon.
Hassan U, Mozayani B, Wong NA
Histopathology 2016 Apr;68(5):755-8. Epub 2015 Sep 8 doi: 10.1111/his.12786. PMID: 26212098
Colon cancer.
Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J
Crit Rev Oncol Hematol 2010 May;74(2):106-33. doi: 10.1016/j.critrevonc.2010.01.010. PMID: 20138539
The adenoma-carcinoma sequence.
Day DW
Scand J Gastroenterol Suppl 1984;104:99-107. PMID: 6597553

Clinical prediction guides

Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT.
Güzel Y, Kaplan İ, Kepenek F, Söğütçü N, Kömek H
Clin Nucl Med 2022 Jul 1;47(7):e509-e512. Epub 2022 Apr 5 doi: 10.1097/RLU.0000000000004166. PMID: 35675142
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
Okerberg ES, Hainley A, Brown H, Aban A, Alemayehu S, Shih A, Wu J, Patricelli MP, Kozarich JW, Nomanbhoy T, Rosenblum JS
PLoS One 2016;11(3):e0152934. Epub 2016 Mar 31 doi: 10.1371/journal.pone.0152934. PMID: 27031502Free PMC Article
UK guidance for the pathological reporting of serrated lesions of the colorectum.
Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843

Recent systematic reviews

Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis.
Di Y, Ding L, Gao L, Huang H
BMC Cancer 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. PMID: 37612616Free PMC Article
Antibody-Functionalized Nanoformulations for Targeted Therapy of Colorectal Cancer: A Systematic Review.
Cepero A, Luque C, Cabeza L, Perazzoli G, Quiñonero F, Mesas C, Melguizo C, Prados J
Int J Nanomedicine 2022;17:5065-5080. Epub 2022 Oct 31 doi: 10.2147/IJN.S368814. PMID: 36345508Free PMC Article
Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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