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Colon Undifferentiated Carcinoma

MedGen UID:
76008
•Concept ID:
C0279643
•
Neoplastic Process
Synonyms: Carcinoma Simplex of the Colon.; Colon Anaplastic Carcinoma; Undifferentiated Carcinoma of Colon; Undifferentiated Carcinoma of the Colon; Undifferentiated Colonic Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the colon. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Undifferentiated Carcinoma

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4. Epub 2019 May 30 doi: 10.1053/j.gastro.2019.05.057. PMID: 31154022Free PMC Article
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article

Diagnosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article

Therapy

Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Scan? Cure? Sure!
Goldberg RM, Ryan DP
Oncologist 2011;16(2):254-6. doi: 10.1634/theoncologist.2011-0014. PMID: 21349952Free PMC Article
Advances in colonic drug delivery.
Basit AW
Drugs 2005;65(14):1991-2007. doi: 10.2165/00003495-200565140-00006. PMID: 16162022
Esophagocoloplasty.
Gregorie HB Jr
Ann Surg 1972 May;175(5):740-51. doi: 10.1097/00000658-197205000-00014. PMID: 5028488Free PMC Article

Prognosis

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1.
Li Z, Zhu Z, Wang Y, Wang Y, Li W, Wang Z, Zhou X, Bao Y
Mol Med Rep 2021 Oct;24(4) Epub 2021 Aug 20 doi: 10.3892/mmr.2021.12375. PMID: 34414457Free PMC Article
Colonic clear cell adenocarcinoma with enteroblastic differentiation.
Shiratori Y, Suzuki K, Ikeya T
Clin J Gastroenterol 2020 Dec;13(6):1196-1199. Epub 2020 Aug 17 doi: 10.1007/s12328-020-01209-1. PMID: 32803644
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Colon cancer.
Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J
Crit Rev Oncol Hematol 2010 May;74(2):106-33. doi: 10.1016/j.critrevonc.2010.01.010. PMID: 20138539

Clinical prediction guides

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1.
Li Z, Zhu Z, Wang Y, Wang Y, Li W, Wang Z, Zhou X, Bao Y
Mol Med Rep 2021 Oct;24(4) Epub 2021 Aug 20 doi: 10.3892/mmr.2021.12375. PMID: 34414457Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Robot-assisted laparoscopic colorectal surgery.
Alimoglu O, Atak I, Orhun K, Eren T
Minerva Chir 2013 Oct;68(5):471-8. PMID: 24101004
Molecular genetics of colon cancer.
Tomlinson I, Ilyas M, Novelli M
Cancer Metastasis Rev 1997 Jun;16(1-2):67-79. doi: 10.1023/a:1005744323215. PMID: 9156280

Recent systematic reviews

Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis.
Di Y, Ding L, Gao L, Huang H
BMC Cancer 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. PMID: 37612616Free PMC Article
Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Medullary carcinoma in the colorectum: a systematic review and meta-analysis.
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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