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Leukemoid reaction of the newborn

MedGen UID:
760708
Concept ID:
C3536761
Finding
Synonyms: Infantile pseudoleukemia; Transient Leukemoid Reaction of the Newborn
SNOMED CT: Leukemoid reaction of the newborn (191273000); Infantile pseudoleukemia (191273000)

Definition

Increased white blood cell count and increased neutrophil precursors resembling leukemia in a neonate or fetus. Often, this is a response to medications received, infection or Down syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemoid reaction of the newborn

Professional guidelines

PubMed

Aziz-Bose R, Wachter F, Chiarle R, Lindeman NI, Kim AS, Degar BA, Davies K, Pikman Y
Blood Adv 2022 May 10;6(9):2893-2896. doi: 10.1182/bloodadvances.2021006865. PMID: 35090166Free PMC Article

Recent clinical studies

Etiology

Mohammad Khuzaini A, Mohd Baharudin JA, Md Fauzi A, Zulkeflee HA, Abdul Halim H, Mazli SK, Osman NFB
J Neonatal Perinatal Med 2024;17(2):269-273. doi: 10.3233/NPM-230146. PMID: 38728206
Sato T, Yoshida K, Toki T, Kanezaki R, Terui K, Saiki R, Ojima M, Ochi Y, Mizuno S, Yoshihara M, Uechi T, Kenmochi N, Tanaka S, Matsubayashi J, Kisai K, Kudo K, Yuzawa K, Takahashi Y, Tanaka T, Yamamoto Y, Kobayashi A, Kamio T, Sasaki S, Shiraishi Y, Chiba K, Tanaka H, Muramatsu H, Hama A, Hasegawa D, Sato A, Koh K, Karakawa S, Kobayashi M, Hara J, Taneyama Y, Imai C, Hasegawa D, Fujita N, Yoshitomi M, Iwamoto S, Yamato G, Saida S, Kiyokawa N, Deguchi T, Ito M, Matsuo H, Adachi S, Hayashi Y, Taga T, Saito AM, Horibe K, Watanabe K, Tomizawa D, Miyano S, Takahashi S, Ogawa S, Ito E
Blood 2024 Jun 20;143(25):2627-2643. doi: 10.1182/blood.2023022247. PMID: 38513239
Okamoto T, Nagaya K, Toriumi N, Sarashina T, Azuma H
Pediatr Int 2021 Oct;63(10):1243-1245. Epub 2021 Jul 4 doi: 10.1111/ped.14583. PMID: 34219329
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293

Diagnosis

Aziz-Bose R, Wachter F, Chiarle R, Lindeman NI, Kim AS, Degar BA, Davies K, Pikman Y
Blood Adv 2022 May 10;6(9):2893-2896. doi: 10.1182/bloodadvances.2021006865. PMID: 35090166Free PMC Article
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Gallagher-Lacey C, Afify Z, Yaish HM, Yoder BA, Christensen RD
Clin Pediatr (Phila) 2017 Mar;56(3):288-289. Epub 2016 Aug 20 doi: 10.1177/0009922816662460. PMID: 27530503
Mandal P, Mukherjee SB
Indian Pediatr 2015 Nov;52(11):973-4. doi: 10.1007/s13312-015-0755-2. PMID: 26615346
Doan S, Bertrand KC, Ma JC, Chauhan A, Warrier R
Clin Pediatr (Phila) 2014 Jul;53(8):804-6. Epub 2014 Mar 20 doi: 10.1177/0009922814527510. PMID: 24658909

Therapy

Yamato G, Tsumura Y, Muramatsu H, Shimada A, Imaizumi T, Tsukagoshi H, Kaburagi T, Shiba N, Yamada Y, Deguchi T, Kawai T, Terui K, Ito E, Watanabe K, Hayashi Y
Blood Adv 2024 Jun 25;8(12):3120-3129. doi: 10.1182/bloodadvances.2023011628. PMID: 38691583Free PMC Article
Watanabe T, Amari S, Tsukamoto K, Ito Y, Tomizawa D, Yoshioka T, Kanamori Y
Pediatr Int 2017 Apr;59(4):515-518. doi: 10.1111/ped.13250. PMID: 28401746
Herrera AJ, Macaraeg AL
South Med J 1986 Jan;79(1):78-9. doi: 10.1097/00007611-198601000-00024. PMID: 3945839
Alcena V
Am J Obstet Gynecol 1982 Dec 1;144(7):852-4. doi: 10.1016/0002-9378(82)90366-0. PMID: 7148909
Anday EK, Harris MC
J Pediatr 1982 Oct;101(4):614-6. doi: 10.1016/s0022-3476(82)80723-3. PMID: 7119969

Prognosis

Sato T, Yoshida K, Toki T, Kanezaki R, Terui K, Saiki R, Ojima M, Ochi Y, Mizuno S, Yoshihara M, Uechi T, Kenmochi N, Tanaka S, Matsubayashi J, Kisai K, Kudo K, Yuzawa K, Takahashi Y, Tanaka T, Yamamoto Y, Kobayashi A, Kamio T, Sasaki S, Shiraishi Y, Chiba K, Tanaka H, Muramatsu H, Hama A, Hasegawa D, Sato A, Koh K, Karakawa S, Kobayashi M, Hara J, Taneyama Y, Imai C, Hasegawa D, Fujita N, Yoshitomi M, Iwamoto S, Yamato G, Saida S, Kiyokawa N, Deguchi T, Ito M, Matsuo H, Adachi S, Hayashi Y, Taga T, Saito AM, Horibe K, Watanabe K, Tomizawa D, Miyano S, Takahashi S, Ogawa S, Ito E
Blood 2024 Jun 20;143(25):2627-2643. doi: 10.1182/blood.2023022247. PMID: 38513239
Triarico S, Trombatore G, Capozza MA, Romano A, Mastrangelo S, Attinà G, Maurizi P, Ruggiero A
Expert Rev Hematol 2022 Feb;15(2):127-135. Epub 2022 Feb 28 doi: 10.1080/17474086.2022.2044780. PMID: 35184659
Roseman AS, Blackburn PR, Bakshi S, Grady L, Abbott MA, Hassan S, Hunt J, Richardson M, Peterson JF, Nguyen P, Greipp PT, Singh R
Cancer Genet 2020 Jun;244:62-64. Epub 2020 May 4 doi: 10.1016/j.cancergen.2020.04.003. PMID: 32464589
Watanabe K
Pediatr Int 2019 Mar;61(3):222-229. Epub 2019 Mar 4 doi: 10.1111/ped.13776. PMID: 30593694
Doan S, Bertrand KC, Ma JC, Chauhan A, Warrier R
Clin Pediatr (Phila) 2014 Jul;53(8):804-6. Epub 2014 Mar 20 doi: 10.1177/0009922814527510. PMID: 24658909

Clinical prediction guides

Mohammad Khuzaini A, Mohd Baharudin JA, Md Fauzi A, Zulkeflee HA, Abdul Halim H, Mazli SK, Osman NFB
J Neonatal Perinatal Med 2024;17(2):269-273. doi: 10.3233/NPM-230146. PMID: 38728206
Yamato G, Tsumura Y, Muramatsu H, Shimada A, Imaizumi T, Tsukagoshi H, Kaburagi T, Shiba N, Yamada Y, Deguchi T, Kawai T, Terui K, Ito E, Watanabe K, Hayashi Y
Blood Adv 2024 Jun 25;8(12):3120-3129. doi: 10.1182/bloodadvances.2023011628. PMID: 38691583Free PMC Article
Watanabe K
Pediatr Int 2019 Mar;61(3):222-229. Epub 2019 Mar 4 doi: 10.1111/ped.13776. PMID: 30593694
Hoofien A, Yarden-Bilavski H, Ashkenazi S, Chodick G, Livni G
Eur J Pediatr 2018 Jul;177(7):1029-1036. Epub 2018 Apr 25 doi: 10.1007/s00431-018-3155-5. PMID: 29696475
Fong CT, Brodeur GM
Cancer Genet Cytogenet 1987 Sep;28(1):55-76. doi: 10.1016/0165-4608(87)90354-2. PMID: 2955886

Recent systematic reviews

Tamblyn JA, Norton A, Spurgeon L, Donovan V, Bedford Russell A, Bonnici J, Perkins K, Vyas P, Roberts I, Kilby MD
Arch Dis Child Fetal Neonatal Ed 2016 Jan;101(1):F67-71. Epub 2015 May 8 doi: 10.1136/archdischild-2014-308004. PMID: 25956670

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