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Oropharyngeal Undifferentiated Carcinoma

MedGen UID:
76095
•Concept ID:
C0280318
•
Neoplastic Process
Synonym: Oropharyngeal Lymphoepithelioma

Definition

A non-keratinizing carcinoma arising from the oropharynx. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate. [from NCI]

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: [email protected]; ESMO Guidelines Committee. Electronic address: [email protected]; ESTRO Executive Board. Electronic address: [email protected]
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
HPV-associated oropharyngeal squamous cell carcinoma.
Smith TJ, Mendez A, Donald C, Nagel TH
JAAPA 2017 Jan;30(1):14-19. doi: 10.1097/01.JAA.0000510985.76167.ed. PMID: 27941569
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Diagnosis

Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma.
Ferris RL, Westra W
Annu Rev Pathol 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424. PMID: 36693202Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: [email protected]; ESMO Guidelines Committee. Electronic address: [email protected]; ESTRO Executive Board. Electronic address: [email protected]
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Masticator space: imaging anatomy for diagnosis.
Meltzer DE, Shatzkes DR
Otolaryngol Clin North Am 2012 Dec;45(6):1233-51. doi: 10.1016/j.otc.2012.08.003. PMID: 23153747
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311).
Ferris RL, Flamand Y, Weinstein GS, Li S, Quon H, Mehra R, Garcia JJ, Chung CH, Gillison ML, Duvvuri U, O'Malley BW Jr, Ozer E, Thomas GR, Koch WM, Gross ND, Bell RB, Saba NF, Lango M, Méndez E, Burtness B
J Clin Oncol 2022 Jan 10;40(2):138-149. Epub 2021 Oct 26 doi: 10.1200/JCO.21.01752. PMID: 34699271Free PMC Article
Therapeutic strategies: Surgery for human papillomavirus-associated oropharyngeal carcinoma.
Mclean T, Fitzgerald C, Boyle JO
J Surg Oncol 2021 Nov;124(6):935-944. Epub 2021 Sep 30 doi: 10.1002/jso.26695. PMID: 34595753
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer.
Pignon JP, Bourhis J, Domenge C, Designé L
Lancet 2000 Mar 18;355(9208):949-55. PMID: 10768432

Prognosis

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: [email protected]; ESMO Guidelines Committee. Electronic address: [email protected]; ESTRO Executive Board. Electronic address: [email protected]
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
An unusual palatine tonsil lesion.
Fabre C, Gil H, Righini CA
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Sep;136(4):331-333. Epub 2019 Jun 17 doi: 10.1016/j.anorl.2019.05.014. PMID: 31221589
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Tonsillar carcinoma.
Guay ME, Lavertu P
Eur Arch Otorhinolaryngol 1995;252(5):259-64. doi: 10.1007/BF00185386. PMID: 7576581

Clinical prediction guides

Ninety-day mortality following transoral robotic surgery or radiation at Commission on Cancer-accredited facilities.
Janopaul-Naylor JR, Rupji M, Tobillo RA, Lorenz JW, Switchenko JM, Tian S, Kaka AS, Qian DC, Schlafstein AJ, Steuer CE, Remick JS, Rudra S, McDonald MW, Saba NF, Stokes WA, Patel MR, Bates JE
Head Neck 2023 Mar;45(3):658-663. Epub 2022 Dec 22 doi: 10.1002/hed.27282. PMID: 36549012Free PMC Article
Presentation and outcomes of patients with clinically T1-2, N0 oropharynx squamous cell carcinoma: The interplay of primary treatment modality and human papillomavirus status.
Al-Qurayshi Z, Zhu VL, Bayon R, Buchakjian MR
Head Neck 2023 Jan;45(1):64-74. Epub 2022 Oct 7 doi: 10.1002/hed.27211. PMID: 36205359
Posttreatment FDG-PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma.
Miller JA, Moradi F, Sundaram V, Liang R, Zhang C, Nguyen NK, Akhtar F, Liu Y, Ren Y, Harandi N, Weng Y, Pollom EL, Colevas AD, Divi V, Holsinger FC, Beadle BM, Le QT, Gensheimer MF
Head Neck 2022 Nov;44(11):2491-2504. Epub 2022 Aug 3 doi: 10.1002/hed.27160. PMID: 35920790
Estimated Cost of Circulating Tumor DNA for Posttreatment Surveillance of Human Papillomavirus-Associated Oropharyngeal Cancer.
Kowalchuk RO, Kamdem Talom BC, Van Abel KM, Ma DM, Waddle MR, Routman DM
JAMA Netw Open 2022 Jan 4;5(1):e2144783. doi: 10.1001/jamanetworkopen.2021.44783. PMID: 35076706Free PMC Article
Interobserver variation in parotid gland delineation: a study of its impact on intensity-modulated radiotherapy solutions with a systematic review of the literature.
Loo SW, Martin WM, Smith P, Cherian S, Roques TW
Br J Radiol 2012 Aug;85(1016):1070-7. doi: 10.1259/bjr/32038456. PMID: 22815411Free PMC Article

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Distant metastases in human papillomavirus-related oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.
Crossley JR, Nelson LL, Chou J, Maxwell JH
Head Neck 2023 Jan;45(1):275-282. Epub 2022 Oct 28 doi: 10.1002/hed.27230. PMID: 36306202
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Racial disparities and human papillomavirus status in oropharyngeal cancer: A systematic review and meta-analysis.
Lenze NR, Farquhar DR, Mazul AL, Masood MM, Zevallos JP
Head Neck 2019 Jan;41(1):256-261. Epub 2018 Dec 18 doi: 10.1002/hed.25414. PMID: 30561088
Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature.
Kreeft AM, van der Molen L, Hilgers FJ, Balm AJ
Eur Arch Otorhinolaryngol 2009 Nov;266(11):1687-1698. doi: 10.1007/s00405-009-1089-2. PMID: 19756680

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