U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unbearable Pain

MedGen UID:
768654
•Concept ID:
C3640014
•
Sign or Symptom

Definition

A sensation of extreme discomfort and anguish that is overwhelming and unendurable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnbearable Pain

Professional guidelines

PubMed

Medical cannabis for chronic pain: can it make a difference in pain management?
Maharajan MK, Yong YJ, Yip HY, Woon SS, Yeap KM, Yap KY, Yip SC, Yap KX
J Anesth 2020 Feb;34(1):95-103. Epub 2019 Sep 18 doi: 10.1007/s00540-019-02680-y. PMID: 31535218
Calciphylaxis: Approach to Diagnosis and Management.
Seethapathy H, Noureddine L
Adv Chronic Kidney Dis 2019 Nov;26(6):484-490. doi: 10.1053/j.ackd.2019.09.005. PMID: 31831126
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036

Recent clinical studies

Etiology

'You have a little human being kicking inside you and an unbearable pain of knowing there will be a void at the end': A meta-ethnography exploring the experience of parents whose baby is diagnosed antenatally with a life limiting or life-threatening condition.
Tatterton MJ, Fisher MJ
Palliat Med 2023 Oct;37(9):1289-1302. Epub 2023 May 2 doi: 10.1177/02692163231172244. PMID: 37129319Free PMC Article
Constitutive Inflammatory Cytokine Storm: A Major Threat to Human Health.
Gupta KK, Khan MA, Singh SK
J Interferon Cytokine Res 2020 Jan;40(1):19-23. Epub 2019 Nov 22 doi: 10.1089/jir.2019.0085. PMID: 31755797
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Post-piercing perichondritis.
Fernandez AP, Neto IC, Anias CR, Pinto PCL, de Carvalho E Castro J, Carpes AF
Braz J Otorhinolaryngol 2008 Nov-Dec;74(6):933-937. doi: 10.1016/S1808-8694(15)30156-7. PMID: 19582352Free PMC Article
Sedation-free colonoscopy.
Takahashi Y, Tanaka H, Kinjo M, Sakumoto K
Dis Colon Rectum 2005 Apr;48(4):855-9. doi: 10.1007/s10350-004-0860-0. PMID: 15768182

Diagnosis

Calciphylaxis: Approach to Diagnosis and Management.
Seethapathy H, Noureddine L
Adv Chronic Kidney Dis 2019 Nov;26(6):484-490. doi: 10.1053/j.ackd.2019.09.005. PMID: 31831126
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Treatment options in painful chronic pancreatitis: a systematic review.
D'Haese JG, Ceyhan GO, Demir IE, Tieftrunk E, Friess H
HPB (Oxford) 2014 Jun;16(6):512-21. Epub 2013 Aug 29 doi: 10.1111/hpb.12173. PMID: 24033614Free PMC Article
Post-piercing perichondritis.
Fernandez AP, Neto IC, Anias CR, Pinto PCL, de Carvalho E Castro J, Carpes AF
Braz J Otorhinolaryngol 2008 Nov-Dec;74(6):933-937. doi: 10.1016/S1808-8694(15)30156-7. PMID: 19582352Free PMC Article
Sedation-free colonoscopy.
Takahashi Y, Tanaka H, Kinjo M, Sakumoto K
Dis Colon Rectum 2005 Apr;48(4):855-9. doi: 10.1007/s10350-004-0860-0. PMID: 15768182

Therapy

Exudate Absorbing and Antimicrobial Hydrogel Integrated with Multifunctional Curcumin-Loaded Magnesium Polyphenol Network for Facilitating Burn Wound Healing.
Gong Y, Wang P, Cao R, Wu J, Ji H, Wang M, Hu C, Huang P, Wang X
ACS Nano 2023 Nov 28;17(22):22355-22370. Epub 2023 Nov 6 doi: 10.1021/acsnano.3c04556. PMID: 37930078
Calciphylaxis: Approach to Diagnosis and Management.
Seethapathy H, Noureddine L
Adv Chronic Kidney Dis 2019 Nov;26(6):484-490. doi: 10.1053/j.ackd.2019.09.005. PMID: 31831126
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Photodynamic Therapy: Past, Present and Future.
Chilakamarthi U, Giribabu L
Chem Rec 2017 Aug;17(8):775-802. Epub 2017 Jan 2 doi: 10.1002/tcr.201600121. PMID: 28042681
Post-piercing perichondritis.
Fernandez AP, Neto IC, Anias CR, Pinto PCL, de Carvalho E Castro J, Carpes AF
Braz J Otorhinolaryngol 2008 Nov-Dec;74(6):933-937. doi: 10.1016/S1808-8694(15)30156-7. PMID: 19582352Free PMC Article

Prognosis

Rheumatoid Arthritis Has Won the Battle but Not the War: How Many Joints Will We Save Tomorrow?
Oberemok VV, Andreeva O, Laikova K, Alieva E, Temirova Z
Medicina (Kaunas) 2023 Oct 18;59(10) doi: 10.3390/medicina59101853. PMID: 37893571Free PMC Article
Factors affecting pain in patients undergoing bilateral cataract surgery.
Liu P, Zhang S, Geng Z, Yuan R, Ye J
Int Ophthalmol 2020 Feb;40(2):297-303. Epub 2019 Oct 17 doi: 10.1007/s10792-019-01178-6. PMID: 31624986
Calciphylaxis: Approach to Diagnosis and Management.
Seethapathy H, Noureddine L
Adv Chronic Kidney Dis 2019 Nov;26(6):484-490. doi: 10.1053/j.ackd.2019.09.005. PMID: 31831126
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036
Pain and pain generation in pancreatic cancer.
di Mola FF, di Sebastiano P
Langenbecks Arch Surg 2008 Nov;393(6):919-22. Epub 2008 Jan 12 doi: 10.1007/s00423-007-0277-z. PMID: 18193269

Clinical prediction guides

Understanding the psychodynamics of the pathway to suicide.
Gibbons R
Int Rev Psychiatry 2024 Jun-Aug;36(4-5):508-516. Epub 2024 May 24 doi: 10.1080/09540261.2024.2351937. PMID: 39470097
Blank pain and pathological mourning in the analytic situation.
Groarke S
Int J Psychoanal 2023 Dec;104(6):1006-1024. Epub 2023 Dec 21 doi: 10.1080/00207578.2023.2234969. PMID: 38127483
Psychological pain and previous suicide attempts in young adults: Results with the Portuguese version of the Psychache Scale.
Campos RC, Holden RR
J Clin Psychol 2020 Oct;76(10):1965-1971. Epub 2020 May 14 doi: 10.1002/jclp.22973. PMID: 32410279
Factors affecting pain in patients undergoing bilateral cataract surgery.
Liu P, Zhang S, Geng Z, Yuan R, Ye J
Int Ophthalmol 2020 Feb;40(2):297-303. Epub 2019 Oct 17 doi: 10.1007/s10792-019-01178-6. PMID: 31624986
Diagnosis and management of spinal infections.
Nagashima H, Tanishima S, Tanida A
J Orthop Sci 2018 Jan;23(1):8-13. Epub 2017 Oct 20 doi: 10.1016/j.jos.2017.09.016. PMID: 29066036

Recent systematic reviews

Prevalence and causes of self-medication for oral health problems: a systematic review and meta-analysis.
Katebi K, Eslami H, Jabbari S
BMC Oral Health 2024 Sep 19;24(1):1115. doi: 10.1186/s12903-024-04900-8. PMID: 39300478Free PMC Article
Safety and efficacy of microwave ablation for benign thyroid nodules and papillary thyroid microcarcinomas: A systematic review and meta-analysis.
Cui T, Jin C, Jiao D, Teng D, Sui G
Eur J Radiol 2019 Sep;118:58-64. Epub 2019 Jun 29 doi: 10.1016/j.ejrad.2019.06.027. PMID: 31439259
Treatment options in painful chronic pancreatitis: a systematic review.
D'Haese JG, Ceyhan GO, Demir IE, Tieftrunk E, Friess H
HPB (Oxford) 2014 Jun;16(6):512-21. Epub 2013 Aug 29 doi: 10.1111/hpb.12173. PMID: 24033614Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...