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Nodding Syndrome

MedGen UID:
772552
Concept ID:
C3658353
Disease or Syndrome
Synonyms: Nodding Syndromes; Syndrome, Nodding; Syndromes, Nodding

Definition

Unexplained neurologic condition characterized by episodes of atonic seizures, convulsions or staring spells with further cognitive decline. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNodding Syndrome

Professional guidelines

PubMed

Colebunders R, Siewe Fodjo JN, Kamoen O, Amaral LJ, Hadermann A, Trevisan C, Taylor MJ, Gauglitz J, Hoerauf A, Sato Y, Polman K, Basáñez MG, Bhwana D, Lakwo T, Abd-Elfarag G, Pion SD
Infect Dis Poverty 2024 Jan 12;13(1):5. doi: 10.1186/s40249-024-01174-8. PMID: 38212805Free PMC Article
Colebunders R, Njamnshi AK, Menon S, Newton CR, Hotterbeekx A, Preux PM, Hopkins A, Vaillant M, Siewe Fodjo JN
PLoS Negl Trop Dis 2021 Jan;15(1):e0008965. Epub 2021 Jan 7 doi: 10.1371/journal.pntd.0008965. PMID: 33411705Free PMC Article
Idro R, Namusoke H, Abbo C, Mutamba BB, Kakooza-Mwesige A, Opoka RO, Musubire AK, Mwaka AD, Opar BT
BMJ Open 2014 Nov 14;4(11):e006476. doi: 10.1136/bmjopen-2014-006476. PMID: 25398677Free PMC Article

Recent clinical studies

Etiology

Soldatos A, Nutman TB, Johnson T, Dowell SF, Sejvar JJ, Wilson MR, DeRisi JL, Inati SK, Groden C, Evans C, O'Connell EM, Toliva BO, Aceng JR, Aryek-Kwe J, Toro C, Stratakis CA, Buckler AG, Cantilena C, Palmore TN, Thurm A, Baker EH, Chang R, Fauni H, Adams D, Macnamara EF, Lau CC, Malicdan MCV, Pusey-Swerdzewski B, Downing R, Bunga S, Thomas JD, Gahl WA, Nath A
Brain 2023 Mar 1;146(3):968-976. doi: 10.1093/brain/awac357. PMID: 36181424Free PMC Article
Idro R, Ogwang R, Kayongo E, Gumisiriza N, Lanyero A, Kakooza-Mwesige A, Opar B
Epileptic Disord 2018 Dec 1;20(6):508-516. doi: 10.1684/epd.2018.1012. PMID: 30530420
Colebunders R, Mandro M, Njamnshi AK, Boussinesq M, Hotterbeekx A, Kamgno J, O'Neill S, Hopkins A, Suykerbuyk P, Basáñez MG, Post RJ, Pedrique B, Preux PM, Stolk WA, Nutman TB, Idro R
Infect Dis Poverty 2018 Mar 22;7(1):23. doi: 10.1186/s40249-018-0400-0. PMID: 29580280Free PMC Article
Årdal C, Røttingen JA
Health Res Policy Syst 2016 Mar 17;14:19. doi: 10.1186/s12961-016-0091-6. PMID: 26983551Free PMC Article
de Polo G, Romaniello R, Otim A, Benjamin K, Bonanni P, Borgatti R
Seizure 2015 Sep;31:64-71. Epub 2015 Jul 20 doi: 10.1016/j.seizure.2015.07.006. PMID: 26362379

Diagnosis

Van Cutsem G, Siewe Fodjo JN, Dekker MCJ, Amaral LJ, Njamnshi AK, Colebunders R
Seizure 2023 Apr;107:132-135. Epub 2023 Mar 31 doi: 10.1016/j.seizure.2023.03.024. PMID: 37023626
Johnson TP, Sejvar J, Nutman TB, Nath A
Annu Rev Pathol 2020 Jan 24;15:395-417. doi: 10.1146/annurev-pathmechdis-012419-032748. PMID: 31977293
Spencer PS, Mazumder R, Palmer VS, Pollanen MS
Rev Neurol (Paris) 2019 Dec;175(10):679-685. Epub 2019 Nov 18 doi: 10.1016/j.neurol.2019.09.005. PMID: 31753452
Burton A
Lancet Neurol 2016 Jan;15(1):30-1. Epub 2015 Dec 8 doi: 10.1016/S1474-4422(15)00350-6. PMID: 26700904
Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article

Therapy

Hadermann A, Amaral LJ, Van Cutsem G, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2023 Feb;39(2):126-138. Epub 2022 Dec 15 doi: 10.1016/j.pt.2022.11.010. PMID: 36528471
Soldatos A, Nutman TB, Johnson T, Dowell SF, Sejvar JJ, Wilson MR, DeRisi JL, Inati SK, Groden C, Evans C, O'Connell EM, Toliva BO, Aceng JR, Aryek-Kwe J, Toro C, Stratakis CA, Buckler AG, Cantilena C, Palmore TN, Thurm A, Baker EH, Chang R, Fauni H, Adams D, Macnamara EF, Lau CC, Malicdan MCV, Pusey-Swerdzewski B, Downing R, Bunga S, Thomas JD, Gahl WA, Nath A
Brain 2023 Mar 1;146(3):968-976. doi: 10.1093/brain/awac357. PMID: 36181424Free PMC Article
Idro R, Opar B, Wamala J, Abbo C, Onzivua S, Mwaka DA, Kakooza-Mwesige A, Mbonye A, Aceng JR
Int J Infect Dis 2016 Apr;45:112-7. Epub 2016 Mar 14 doi: 10.1016/j.ijid.2016.03.002. PMID: 26987477
Colebunders R, Post R, O'Neill S, Haesaert G, Opar B, Lakwo T, Laudisoit A, Hendy A
Trop Med Int Health 2015 Feb;20(2):194-200. Epub 2014 Nov 19 doi: 10.1111/tmi.12421. PMID: 25348848
Korevaar DA, Visser BJ
Int J Infect Dis 2013 Mar;17(3):e149-52. Epub 2012 Nov 6 doi: 10.1016/j.ijid.2012.09.015. PMID: 23137614

Prognosis

Pollanen MS, Onzivua S, McKeever PM, Robertson J, Mackenzie IR, Kovacs GG, Olwa F, Kitara DL, Fong A
Brain 2023 Mar 1;146(3):954-967. doi: 10.1093/brain/awac137. PMID: 35411378Free PMC Article
Årdal C, Røttingen JA
Health Res Policy Syst 2016 Mar 17;14:19. doi: 10.1186/s12961-016-0091-6. PMID: 26983551Free PMC Article
de Polo G, Romaniello R, Otim A, Benjamin K, Bonanni P, Borgatti R
Seizure 2015 Sep;31:64-71. Epub 2015 Jul 20 doi: 10.1016/j.seizure.2015.07.006. PMID: 26362379
Iyengar PJ, Wamala J, Ratto J, Blanton C, Malimbo M, Lukwago L, Becknell S, Downing R, Bunga S, Sejvar J, Makumbi I; Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 2014 Jul 18;63(28):603-6. PMID: 25029112Free PMC Article
Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article

Clinical prediction guides

Soldatos A, Nutman TB, Johnson T, Dowell SF, Sejvar JJ, Wilson MR, DeRisi JL, Inati SK, Groden C, Evans C, O'Connell EM, Toliva BO, Aceng JR, Aryek-Kwe J, Toro C, Stratakis CA, Buckler AG, Cantilena C, Palmore TN, Thurm A, Baker EH, Chang R, Fauni H, Adams D, Macnamara EF, Lau CC, Malicdan MCV, Pusey-Swerdzewski B, Downing R, Bunga S, Thomas JD, Gahl WA, Nath A
Brain 2023 Mar 1;146(3):968-976. doi: 10.1093/brain/awac357. PMID: 36181424Free PMC Article
Pollanen MS, Onzivua S, McKeever PM, Robertson J, Mackenzie IR, Kovacs GG, Olwa F, Kitara DL, Fong A
Brain 2023 Mar 1;146(3):954-967. doi: 10.1093/brain/awac137. PMID: 35411378Free PMC Article
Hotterbeekx A, Lammens M, Idro R, Akun PR, Lukande R, Akena G, Nath A, Taylor J, Olwa F, Kumar-Singh S, Colebunders R
J Neuropathol Exp Neurol 2019 Nov 1;78(11):1049-1058. doi: 10.1093/jnen/nlz090. PMID: 31553445Free PMC Article
Colebunders R, Nelson Siewe FJ, Hotterbeekx A
Trends Parasitol 2018 Mar;34(3):208-216. Epub 2017 Dec 26 doi: 10.1016/j.pt.2017.11.009. PMID: 29288080
Idro R, Opar B, Wamala J, Abbo C, Onzivua S, Mwaka DA, Kakooza-Mwesige A, Mbonye A, Aceng JR
Int J Infect Dis 2016 Apr;45:112-7. Epub 2016 Mar 14 doi: 10.1016/j.ijid.2016.03.002. PMID: 26987477

Recent systematic reviews

Metanmo S, Dossa D, Ahmat DN, Winkler AS, Boumediene F
Neuroepidemiology 2024;58(2):92-119. Epub 2024 Jan 15 doi: 10.1159/000536013. PMID: 38171341
Siewe Fodjo JN, Van Cutsem G, Amaral LJ, Colebunders R
Seizure 2023 Aug;110:253-261. Epub 2023 Jul 10 doi: 10.1016/j.seizure.2023.07.006. PMID: 37451075
Luna J, Metanmo S, Boumediene F, Mbelesso P, Auditeau E, Ajzenberg D, Preux PM
J Neurol Sci 2021 Feb 15;421:117314. Epub 2021 Jan 9 doi: 10.1016/j.jns.2021.117314. PMID: 33493958

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