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Toxic polyneuropathy

MedGen UID:
78747
•Concept ID:
C0270934
•
Disease or Syndrome
Synonyms: Polyneuropathy due to toxic agents; Toxic Polyneuropathy
SNOMED CT: Toxic polyneuropathy (45600000); Polyneuropathy due to toxic agents (45600000)

Definition

Polyneuropathy that is caused by exposure to toxins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic polyneuropathy

Professional guidelines

PubMed

POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2021 Jul 1;96(7):872-888. Epub 2021 May 31 doi: 10.1002/ajh.26240. PMID: 34000085
Diagnosis and management of sensory polyneuropathy.
Gwathmey KG, Pearson KT
BMJ 2019 May 8;365:l1108. doi: 10.1136/bmj.l1108. PMID: 31068323
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Recent clinical studies

Etiology

Sequencing of Charcot-Marie-Tooth disease genes in a toxic polyneuropathy.
Beutler AS, Kulkarni AA, Kanwar R, Klein CJ, Therneau TM, Qin R, Banck MS, Boora GK, Ruddy KJ, Wu Y, Smalley RL, Cunningham JM, Le-Lindqwister NA, Beyerlein P, Schroth GP, Windebank AJ, Züchner S, Loprinzi CL
Ann Neurol 2014 Nov;76(5):727-37. Epub 2014 Sep 17 doi: 10.1002/ana.24265. PMID: 25164601Free PMC Article
Impairment of colour vision in patients with n-hexane exposure-dependent toxic polyneuropathy.
Issever H, Malat G, Sabuncu HH, Yuksel N
Occup Med (Lond) 2002 Jun;52(4):183-6. doi: 10.1093/occmed/52.4.183. PMID: 12091583
Increased expression of glial cell line-derived neurotrophic factor mRNA in muscle biopsies from patients with amyotrophic lateral sclerosis.
Grundström E, Askmark H, Lindeberg J, Nygren I, Ebendal T, Aquilonius SM
J Neurol Sci 1999 Jan 15;162(2):169-73. doi: 10.1016/s0022-510x(98)00333-5. PMID: 10202982
Peripheral nervous system and spinal cord involvement in lymphoma.
Correale J, Monteverde DA, Bueri JA, Reich EG
Acta Neurol Scand 1991 Jan;83(1):45-51. doi: 10.1111/j.1600-0404.1991.tb03957.x. PMID: 1849335
Toxic polyneuropathy of shoe workers in Italy. A clinical, neurophysiological and follow-up study.
Passero S, Battistini N, Cioni R, Giannini F, Paradiso C, Battista F, Carboncini F, Sartorelli E
Ital J Neurol Sci 1983 Dec;4(4):463-72. doi: 10.1007/BF02125628. PMID: 6674248

Diagnosis

Peripheral neuropathy: an underreported neurologic manifestation of inflammatory bowel disease.
García-Cabo C, Morís G
Eur J Intern Med 2015 Sep;26(7):468-75. Epub 2015 Jul 23 doi: 10.1016/j.ejim.2015.07.013. PMID: 26211733
Incidence of polyneuropathy in Utrecht, the Netherlands.
Visser NA, Notermans NC, Linssen RS, van den Berg LH, Vrancken AF
Neurology 2015 Jan 20;84(3):259-64. Epub 2014 Dec 12 doi: 10.1212/WNL.0000000000001160. PMID: 25503982
Arsenic toxicity from homeopathic treatment.
Chakraborti D, Mukherjee SC, Saha KC, Chowdhury UK, Rahman MM, Sengupta MK
J Toxicol Clin Toxicol 2003;41(7):963-7. doi: 10.1081/clt-120026518. PMID: 14705842
Effects of allyl chloride on occupationally exposed subjects.
He FS, Zhang SL
Scand J Work Environ Health 1985;11 Suppl 4:43-5. PMID: 3008322
Occupational peripheral neuropathies.
Lotti M, Becker CE, Aminoff MJ
West J Med 1982 Dec;137(6):493-8. PMID: 6299013Free PMC Article

Therapy

Peripheral neuropathy: an underreported neurologic manifestation of inflammatory bowel disease.
García-Cabo C, Morís G
Eur J Intern Med 2015 Sep;26(7):468-75. Epub 2015 Jul 23 doi: 10.1016/j.ejim.2015.07.013. PMID: 26211733
Toxicity of maduramicin.
Sharma N, Bhalla A, Varma S, Jain S, Singh S
Emerg Med J 2005 Dec;22(12):880-2. doi: 10.1136/emj.2004.020883. PMID: 16299200Free PMC Article
Arsenic toxicity from homeopathic treatment.
Chakraborti D, Mukherjee SC, Saha KC, Chowdhury UK, Rahman MM, Sengupta MK
J Toxicol Clin Toxicol 2003;41(7):963-7. doi: 10.1081/clt-120026518. PMID: 14705842
Toxic polyneuropathy due to glue-sniffing. Report of two cases with a light and electron-microscopic study of the peripheral nerves and muscles.
Shirabe T, Tsuda T, Terao A, Araki S
J Neurol Sci 1974 Jan;21(1):101-13. doi: 10.1016/0022-510x(74)90110-5. PMID: 4374510
Toxic polyneuropathy produced by methyl N-butyl ketone.
Mendell JR, Saida K, Ganansia MF, Jackson DB, Weiss H, Gardier RW, Chrisman C, Allen N, Couri D, O'Neill J, Marks B, Hetland L
Science 1974 Aug 30;185(4153):787-9. doi: 10.1126/science.185.4153.787. PMID: 4367263

Prognosis

Incidence of polyneuropathy in Utrecht, the Netherlands.
Visser NA, Notermans NC, Linssen RS, van den Berg LH, Vrancken AF
Neurology 2015 Jan 20;84(3):259-64. Epub 2014 Dec 12 doi: 10.1212/WNL.0000000000001160. PMID: 25503982
Lethal African trypanosomiasis in a traveler: MRI and neuropathology.
Braakman HM, van de Molengraft FJ, Hubert WW, Boerman DH
Neurology 2006 Apr 11;66(7):1094-6. doi: 10.1212/01.wnl.0000209306.41647.13. PMID: 16606924
Toxicity of maduramicin.
Sharma N, Bhalla A, Varma S, Jain S, Singh S
Emerg Med J 2005 Dec;22(12):880-2. doi: 10.1136/emj.2004.020883. PMID: 16299200Free PMC Article
Chronic polyneuropathies in Vest-Agder, Norway.
Mygland A, Monstad P
Eur J Neurol 2001 Mar;8(2):157-65. doi: 10.1046/j.1468-1331.2001.00187.x. PMID: 11284994
Peripheral nervous system and spinal cord involvement in lymphoma.
Correale J, Monteverde DA, Bueri JA, Reich EG
Acta Neurol Scand 1991 Jan;83(1):45-51. doi: 10.1111/j.1600-0404.1991.tb03957.x. PMID: 1849335

Clinical prediction guides

Chronic polyneuropathies in Vest-Agder, Norway.
Mygland A, Monstad P
Eur J Neurol 2001 Mar;8(2):157-65. doi: 10.1046/j.1468-1331.2001.00187.x. PMID: 11284994
Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane.
Governa M, Calisti R, Coppa G, Tagliavento G, Colombi A, Troni W
J Toxicol Environ Health 1987;20(3):219-28. doi: 10.1080/15287398709530976. PMID: 3029393
Toxic polyneuropathy of shoe workers in Italy. A clinical, neurophysiological and follow-up study.
Passero S, Battistini N, Cioni R, Giannini F, Paradiso C, Battista F, Carboncini F, Sartorelli E
Ital J Neurol Sci 1983 Dec;4(4):463-72. doi: 10.1007/BF02125628. PMID: 6674248
Toxic polyneuropathies after sniffing a glue thinner.
Altenkirch H, Mager J, Stoltenburg G, Helmbrecht J
J Neurol 1977 Jan 13;214(2):137-52. doi: 10.1007/BF02430351. PMID: 64597
Toxic polyneuropathy produced by methyl N-butyl ketone.
Mendell JR, Saida K, Ganansia MF, Jackson DB, Weiss H, Gardier RW, Chrisman C, Allen N, Couri D, O'Neill J, Marks B, Hetland L
Science 1974 Aug 30;185(4153):787-9. doi: 10.1126/science.185.4153.787. PMID: 4367263

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