U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute megakaryoblastic leukemia in adult

MedGen UID:
79016
Concept ID:
C0279632
Neoplastic Process
Synonyms: acute megakaryoblastic leukemia in adult; Adult Acute M7 Leukemia; Adult Acute Megakaryoblastic Leukemia; Adult Acute Megakaryocytic Leukemia; Adult Acute Megakaryocytic Leukemia (M7); M7 Adult Acute Leukemia; M7 Adult Acute Megakaryocytic Leukemia
 
Monarch Initiative: MONDO:0971091

Definition

An acute megakaryoblastic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute megakaryoblastic leukemia in adult

Professional guidelines

PubMed

Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ
Int J Lab Hematol 2013 Dec;35(6):629-36. Epub 2013 May 22 doi: 10.1111/ijlh.12101. PMID: 23693053
Helleberg C, Knudsen H, Hansen PB, Nikolajsen K, Kjaersgaard E, Ralfkiaer E, Johnsen HE
Leukemia 1997 Jun;11(6):830-4. doi: 10.1038/sj.leu.2400648. PMID: 9177436
Ruiz-Argüelles GJ, Marín-Lopez A, Lobato-Mendizábal E, Ruiz-Argüelles A, Nichols WL, Katzman JA
Br J Haematol 1986 Jan;62(1):55-63. doi: 10.1111/j.1365-2141.1986.tb02900.x. PMID: 3942696

Recent clinical studies

Etiology

Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Liu ZJ, Sola-Visner M
Curr Opin Hematol 2011 Sep;18(5):330-7. doi: 10.1097/MOH.0b013e3283497ed5. PMID: 21738028
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Diagnosis

Wertheim G
Clin Lab Med 2021 Sep;41(3):541-550. doi: 10.1016/j.cll.2021.04.002. PMID: 34304781
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167
de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA
Nat Genet 2017 Mar;49(3):451-456. Epub 2017 Jan 23 doi: 10.1038/ng.3772. PMID: 28112737Free PMC Article
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Therapy

Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Kandi R, Gutti U, Saladi RG, Gutti RK
Hematol Oncol Stem Cell Ther 2015 Jun;8(2):95-7. Epub 2014 Dec 27 doi: 10.1016/j.hemonc.2014.11.008. PMID: 25571789
Khan I, Malinge S, Crispino J
Crit Rev Oncog 2011;16(1-2):25-36. doi: 10.1615/critrevoncog.v16.i1-2.40. PMID: 22150305Free PMC Article
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128
Hossfeld DK, Tormey D, Ellison RR
Cancer 1975 Aug;36(2):576-81. doi: 10.1002/1097-0142(197508)36:2<576::aid-cncr2820360237>3.0.co;2-g. PMID: 1171722

Prognosis

Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Daniëls L, Guerti K, Vermeulen K, De Raeve H, Van Assche E, Van de Velde AL, Berneman ZN, Van Der Planken M
Acta Clin Belg 2007 Sep-Oct;62(5):308-14. doi: 10.1179/acb.2007.047. PMID: 18229464

Clinical prediction guides

Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T
Cancer Discov 2019 Dec;9(12):1736-1753. Epub 2019 Oct 29 doi: 10.1158/2159-8290.CD-18-1463. PMID: 31662298
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
Malinge S, Ragu C, Della-Valle V, Pisani D, Constantinescu SN, Perez C, Villeval JL, Reinhardt D, Landman-Parker J, Michaux L, Dastugue N, Baruchel A, Vainchenker W, Bourquin JP, Penard-Lacronique V, Bernard OA
Blood 2008 Nov 15;112(10):4220-6. Epub 2008 Aug 28 doi: 10.1182/blood-2008-01-136366. PMID: 18755984
Gilliland DG, Jordan CT, Felix CA
Hematology Am Soc Hematol Educ Program 2004:80-97. doi: 10.1182/asheducation-2004.1.80. PMID: 15561678

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...