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Diffuse gastric adenocarcinoma

MedGen UID:
79019
•Concept ID:
C0279635
•
Neoplastic Process
Synonyms: Adenocarcinoma of Linitis Plastica Type; adenocarcinoma of linitis plastica type; Adenocarcinoma of the Linitis Plastica Type; adenocarcinoma of the linitis plastica type; carcinoma, diffuse type; carcinoma, diffuse type (morphologic abnormality); Diffuse Adenocarcinoma of Stomach; diffuse adenocarcinoma of stomach; Diffuse Adenocarcinoma of the Stomach; diffuse adenocarcinoma of the stomach; diffuse gastric adenocarcinoma; Diffuse Stomach Adenocarcinoma; diffuse stomach adenocarcinoma; diffuse type stomach adenocarcinoma; Gastric Diffuse Adenocarcinoma; gastric diffuse adenocarcinoma; stomach diffuse type adenocarcinoma
 
Monarch Initiative: MONDO:0005017

Definition

An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse gastric adenocarcinoma

Professional guidelines

PubMed

Survival following operative management of gastric linitis plastica compared with non-operative management.
Thompson RJ, Ranaghan L, Kennedy R, Clements W, Carey PD, Kennedy JA
Ann R Coll Surg Engl 2017 Mar;99(3):228-232. Epub 2016 Nov 4 doi: 10.1308/rcsann.2016.0337. PMID: 27809576Free PMC Article

Recent clinical studies

Etiology

Predictors of self-expanding metallic stent dysfunction in malignant gastric outlet obstruction.
Suder-Castro LS, Ramírez-Solís ME, Hernández-Guerrero AI, de la Mora-Levy JG, Alonso-Lárraga JO, Hernández-Lara AH
Rev Gastroenterol Mex (Engl Ed) 2020 Jul-Sep;85(3):275-281. Epub 2020 Mar 27 doi: 10.1016/j.rgmx.2019.07.009. PMID: 32229056
Specific Histopathologic Features Aid in Distinguishing Diffuse-type Gastric Adenocarcinoma From Metastatic Lobular Breast Carcinoma.
Clinton LK, Plesec T, Goldblum JR, Hajifathalian K, Downs-Kelly E, Patil DT
Am J Surg Pathol 2020 Jan;44(1):77-86. doi: 10.1097/PAS.0000000000001341. PMID: 31403964
A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.
Ajani JA, Abramov M, Bondarenko I, Shparyk Y, Gorbunova V, Hontsa A, Otchenash N, Alsina M, Lazarev S, Feliu J, Elme A, Esko V, Abdalla K, Verma U, Benedetti F, Aoyama T, Mizuguchi H, Makris L, Rosati G; DIGEST Study Group
Ann Oncol 2017 Sep 1;28(9):2142-2148. doi: 10.1093/annonc/mdx275. PMID: 28911091
Survival following operative management of gastric linitis plastica compared with non-operative management.
Thompson RJ, Ranaghan L, Kennedy R, Clements W, Carey PD, Kennedy JA
Ann R Coll Surg Engl 2017 Mar;99(3):228-232. Epub 2016 Nov 4 doi: 10.1308/rcsann.2016.0337. PMID: 27809576Free PMC Article
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer.
Norton JA, Ham CM, Van Dam J, Jeffrey RB, Longacre TA, Huntsman DG, Chun N, Kurian AW, Ford JM
Ann Surg 2007 Jun;245(6):873-9. doi: 10.1097/01.sla.0000254370.29893.e4. PMID: 17522512Free PMC Article

Diagnosis

Diffuse gastric adenocarcinoma during pregnancy and genetic counseling.
Gutiérrez Pérez C, Rodríguez Ledesma I, Blanco Abad C, Catoya Villa JL, Chivato Martín-Falquina I, Cuenca Zarzuela A, López Muñoz AM
Rev Esp Enferm Dig 2023 Oct;115(10):580-581. doi: 10.17235/reed.2022.9412/2022. PMID: 36562524
L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article
Gastric adenocarcinoma in childhood: a case report and a literature review.
Bustamante RH, Romero W
Cir Pediatr 2021 Jul 1;34(3):151-155. PMID: 34254755
Tailoring subtractive cell biopanning to identify diffuse gastric adenocarcinoma-associated antigens via human scFv antibodies.
Mehdipour T, Tohidkia MR, Ata Saei A, Kazemi A, Khajeh S, Rahim Rahimi AA, Nikfarjam S, Farhadi M, Halimi M, Soleimani R, Zubarev RA, Nouri M
Immunology 2020 Jan;159(1):96-108. Epub 2019 Nov 8 doi: 10.1111/imm.13129. PMID: 31596953Free PMC Article
Specific Histopathologic Features Aid in Distinguishing Diffuse-type Gastric Adenocarcinoma From Metastatic Lobular Breast Carcinoma.
Clinton LK, Plesec T, Goldblum JR, Hajifathalian K, Downs-Kelly E, Patil DT
Am J Surg Pathol 2020 Jan;44(1):77-86. doi: 10.1097/PAS.0000000000001341. PMID: 31403964

Therapy

The role of magnification endoscopy in the early diagnosis of gastric signet ring cell carcinoma.
Gómez Díez C, Wolfe García PM, García Alles L, Terán Lantarón Á
Rev Esp Enferm Dig 2024 Aug;116(8):442-443. doi: 10.17235/reed.2023.9364/2022. PMID: 36719330
A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.
Ajani JA, Abramov M, Bondarenko I, Shparyk Y, Gorbunova V, Hontsa A, Otchenash N, Alsina M, Lazarev S, Feliu J, Elme A, Esko V, Abdalla K, Verma U, Benedetti F, Aoyama T, Mizuguchi H, Makris L, Rosati G; DIGEST Study Group
Ann Oncol 2017 Sep 1;28(9):2142-2148. doi: 10.1093/annonc/mdx275. PMID: 28911091
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer.
Norton JA, Ham CM, Van Dam J, Jeffrey RB, Longacre TA, Huntsman DG, Chun N, Kurian AW, Ford JM
Ann Surg 2007 Jun;245(6):873-9. doi: 10.1097/01.sla.0000254370.29893.e4. PMID: 17522512Free PMC Article

Prognosis

L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article
Mining topoisomerase isoforms in gastric cancer.
Hou G, Deng J, You X, Chen J, Jiang Y, Qian T, Bi Y, Song B, Xu Y, Yang X
Gene 2020 Sep 5;754:144859. Epub 2020 Jun 11 doi: 10.1016/j.gene.2020.144859. PMID: 32535049
Tailoring subtractive cell biopanning to identify diffuse gastric adenocarcinoma-associated antigens via human scFv antibodies.
Mehdipour T, Tohidkia MR, Ata Saei A, Kazemi A, Khajeh S, Rahim Rahimi AA, Nikfarjam S, Farhadi M, Halimi M, Soleimani R, Zubarev RA, Nouri M
Immunology 2020 Jan;159(1):96-108. Epub 2019 Nov 8 doi: 10.1111/imm.13129. PMID: 31596953Free PMC Article
Specific Histopathologic Features Aid in Distinguishing Diffuse-type Gastric Adenocarcinoma From Metastatic Lobular Breast Carcinoma.
Clinton LK, Plesec T, Goldblum JR, Hajifathalian K, Downs-Kelly E, Patil DT
Am J Surg Pathol 2020 Jan;44(1):77-86. doi: 10.1097/PAS.0000000000001341. PMID: 31403964
Survival following operative management of gastric linitis plastica compared with non-operative management.
Thompson RJ, Ranaghan L, Kennedy R, Clements W, Carey PD, Kennedy JA
Ann R Coll Surg Engl 2017 Mar;99(3):228-232. Epub 2016 Nov 4 doi: 10.1308/rcsann.2016.0337. PMID: 27809576Free PMC Article

Clinical prediction guides

L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article
Predictors of self-expanding metallic stent dysfunction in malignant gastric outlet obstruction.
Suder-Castro LS, Ramírez-Solís ME, Hernández-Guerrero AI, de la Mora-Levy JG, Alonso-Lárraga JO, Hernández-Lara AH
Rev Gastroenterol Mex (Engl Ed) 2020 Jul-Sep;85(3):275-281. Epub 2020 Mar 27 doi: 10.1016/j.rgmx.2019.07.009. PMID: 32229056
Biflorin inhibits the proliferation of gastric cancer cells by decreasing MYC expression.
Barbosa-Jobim GS, Costa-Lira É, Ralph ACL, Gregório L, Lemos TLG, Burbano RR, Calcagno DQ, Smith MAC, Montenegro RC, Vasconcellos MC
Toxicol In Vitro 2020 Mar;63:104735. Epub 2019 Nov 18 doi: 10.1016/j.tiv.2019.104735. PMID: 31751609
Tailoring subtractive cell biopanning to identify diffuse gastric adenocarcinoma-associated antigens via human scFv antibodies.
Mehdipour T, Tohidkia MR, Ata Saei A, Kazemi A, Khajeh S, Rahim Rahimi AA, Nikfarjam S, Farhadi M, Halimi M, Soleimani R, Zubarev RA, Nouri M
Immunology 2020 Jan;159(1):96-108. Epub 2019 Nov 8 doi: 10.1111/imm.13129. PMID: 31596953Free PMC Article
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Shen JX, Liu J, Li GW, Huang YT, Wu HT
Oncotarget 2016 May 3;7(18):25340-9. doi: 10.18632/oncotarget.8294. PMID: 27015121Free PMC Article

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