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Rhesus Hemolytic Disease of the Newborn

MedGen UID:
810688
•Concept ID:
C0853694
•
Disease or Syndrome
Synonyms: Erythroblastosis Fetalis, Rh Disease; RhD Hemolytic Disease of the Newborn; Rhesus D Hemolytic Disease of the Newborn; Rhesus Disease

Definition

A disorder caused when there is a Rh-factor blood-type incompatibility between the mother and fetus, and the mother''s immune system forms antibodies that attack the red blood cells of her unborn child. This disorder can only occur if the mother is Rh-negative and the fetus is Rh-positive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhesus Hemolytic Disease of the Newborn

Professional guidelines

PubMed

Jack Bowman: Winnipeg's contributions to the treatment and prevention of Rhesus hemolytic disease of the newborn.
Warren P, Jamieson JC
Transfus Med Rev 2010 Jan;24(1):68-76. doi: 10.1016/j.tmrv.2009.09.007. PMID: 19962577
The impact of phototherapy in the management of neonatal hyperbilirubinemia: comparison of historical cohorts.
Valaes T, Koliopoulos C, Koltsidopoulos A
Acta Paediatr 1996 Mar;85(3):273-6. doi: 10.1111/j.1651-2227.1996.tb14013.x. PMID: 8695978

Recent clinical studies

Etiology

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction.
Zipursky A, Bhutani VK
Semin Fetal Neonatal Med 2015 Feb;20(1):2-5. Epub 2015 Jan 9 doi: 10.1016/j.siny.2014.12.001. PMID: 25582277

Diagnosis

History and current standard of postnatal management in hemolytic disease of the fetus and newborn.
De Winter DP, Hulzebos C, Van 't Oever RM, De Haas M, Verweij EJ, Lopriore E
Eur J Pediatr 2023 Feb;182(2):489-500. Epub 2022 Dec 5 doi: 10.1007/s00431-022-04724-0. PMID: 36469119
Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
How to use: the direct antiglobulin test in newborns.
Keir A, Agpalo M, Lieberman L, Callum J
Arch Dis Child Educ Pract Ed 2015 Aug;100(4):198-203. Epub 2014 Nov 13 doi: 10.1136/archdischild-2013-305553. PMID: 25395493
Anti-E in pregnancy.
Moran P, Robson SC, Reid MM
BJOG 2000 Nov;107(11):1436-8. doi: 10.1111/j.1471-0528.2000.tb11662.x. PMID: 11117776

Therapy

The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Detection of fetomaternal hemorrhage.
Kim YA, Makar RS
Am J Hematol 2012 Apr;87(4):417-23. Epub 2012 Jan 9 doi: 10.1002/ajh.22255. PMID: 22231030
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
Smits-Wintjens VE, Walther FJ, Lopriore E
Semin Fetal Neonatal Med 2008 Aug;13(4):265-71. Epub 2008 Apr 2 doi: 10.1016/j.siny.2008.02.005. PMID: 18387863
Rhesus disease: the model for fetal therapy.
Nicolaides KH, Rodeck CH
Br J Hosp Med 1985 Sep;34(3):141-8. PMID: 3933599

Prognosis

The rhesus incompatible pregnancy and its consequences for affected fetuses and neonates.
Tyndall C, Cuzzilla R, Kane SC
Transfus Apher Sci 2020 Oct;59(5):102948. Epub 2020 Sep 16 doi: 10.1016/j.transci.2020.102948. PMID: 33008742
The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature.
Olusanya BO, Osibanjo FB, Mabogunje CA, Slusher TM, Olowe SA
Niger J Clin Pract 2016 Jan-Feb;19(1):1-17. doi: 10.4103/1119-3077.173703. PMID: 26755212
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
The investigation of infants with RhD-negative mothers: can we safely omit the umbilical cord blood direct antiglobulin test?
James RM, McGuire W, Smith DP
Arch Dis Child Fetal Neonatal Ed 2011 Jul;96(4):F301-4. Epub 2010 Jul 21 doi: 10.1136/adc.2009.175851. PMID: 20659940
Rhesus haemolytic disease.
Whittle MJ
Arch Dis Child 1992 Jan;67(1 Spec No):65-8. doi: 10.1136/adc.67.1_spec_no.65. PMID: 1536591Free PMC Article

Clinical prediction guides

Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D, Lopriore E
BMC Pregnancy Childbirth 2023 Oct 18;23(1):738. doi: 10.1186/s12884-023-06061-y. PMID: 37853331Free PMC Article
Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
The investigation of infants with RhD-negative mothers: can we safely omit the umbilical cord blood direct antiglobulin test?
James RM, McGuire W, Smith DP
Arch Dis Child Fetal Neonatal Ed 2011 Jul;96(4):F301-4. Epub 2010 Jul 21 doi: 10.1136/adc.2009.175851. PMID: 20659940
Anti-Kell in pregnancy.
Leggat HM, Gibson JM, Barron SL, Reid MM
Br J Obstet Gynaecol 1991 Feb;98(2):162-5. doi: 10.1111/j.1471-0528.1991.tb13362.x. PMID: 2004052

Recent systematic reviews

Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.
de Winter DP, Kaminski A, Tjoa ML, Oepkes D
BMC Pregnancy Childbirth 2023 Jan 7;23(1):12. doi: 10.1186/s12884-022-05329-z. PMID: 36611144Free PMC Article
Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.
Olusanya BO, Osibanjo FB, Slusher TM
PLoS One 2015;10(2):e0117229. Epub 2015 Feb 12 doi: 10.1371/journal.pone.0117229. PMID: 25675342Free PMC Article
Management and prevention of red cell alloimmunization in pregnancy: a systematic review.
Moise KJ Jr, Argoti PS
Obstet Gynecol 2012 Nov;120(5):1132-9. doi: 10.1097/aog.0b013e31826d7dc1. PMID: 23090532
Etiology of nonimmune hydrops fetalis: a systematic review.
Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E
Am J Med Genet A 2009 May;149A(5):844-51. doi: 10.1002/ajmg.a.32655. PMID: 19334091
Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates.
Alcock GS, Liley H
Cochrane Database Syst Rev 2002;(3):CD003313. doi: 10.1002/14651858.CD003313. PMID: 12137687

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