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Postpartum Obstetric Thromboembolism

MedGen UID:
821253
•Concept ID:
C3828505
•
Disease or Syndrome

Definition

Presence of a blood clot in the maternal vascular system which originated from a distant site during the postpartum period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostpartum Obstetric Thromboembolism

Professional guidelines

PubMed

Management of venous thromboembolism in pregnancy.
Kalaitzopoulos DR, Panagopoulos A, Samant S, Ghalib N, Kadillari J, Daniilidis A, Samartzis N, Makadia J, Palaiodimos L, Kokkinidis DG, Spyrou N
Thromb Res 2022 Mar;211:106-113. Epub 2022 Feb 7 doi: 10.1016/j.thromres.2022.02.002. PMID: 35149395
ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins–Obstetrics
Obstet Gynecol 2018 Jul;132(1):e18-e34. doi: 10.1097/AOG.0000000000002703. PMID: 29939939
ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Jul;132(1):e1-e17. doi: 10.1097/AOG.0000000000002706. PMID: 29939938

Recent clinical studies

Etiology

Anticoagulation Regimens in Pregnancy.
Saad A, Safarzadeh M, Shepherd M
Obstet Gynecol Clin North Am 2023 Mar;50(1):241-249. doi: 10.1016/j.ogc.2022.10.010. PMID: 36822707
Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins–Obstetrics
Obstet Gynecol 2018 Jul;132(1):e18-e34. doi: 10.1097/AOG.0000000000002703. PMID: 29939939
ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Jul;132(1):e1-e17. doi: 10.1097/AOG.0000000000002706. PMID: 29939938
Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child.
Catalano PM, Shankar K
BMJ 2017 Feb 8;356:j1. doi: 10.1136/bmj.j1. PMID: 28179267Free PMC Article

Diagnosis

Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.
Maughan BC, Marin M, Han J, Gibbins KJ, Brixey AG, Caughey AB, Kline JA, Jarman AF
Obstet Gynecol Surv 2022 Jul;77(7):433-444. doi: 10.1097/OGX.0000000000001043. PMID: 35792687Free PMC Article
Management of venous thromboembolism in pregnancy.
Kalaitzopoulos DR, Panagopoulos A, Samant S, Ghalib N, Kadillari J, Daniilidis A, Samartzis N, Makadia J, Palaiodimos L, Kokkinidis DG, Spyrou N
Thromb Res 2022 Mar;211:106-113. Epub 2022 Feb 7 doi: 10.1016/j.thromres.2022.02.002. PMID: 35149395
Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins–Obstetrics
Obstet Gynecol 2018 Jul;132(1):e18-e34. doi: 10.1097/AOG.0000000000002703. PMID: 29939939
ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Jul;132(1):e1-e17. doi: 10.1097/AOG.0000000000002706. PMID: 29939938

Therapy

Anticoagulation Regimens in Pregnancy.
Saad A, Safarzadeh M, Shepherd M
Obstet Gynecol Clin North Am 2023 Mar;50(1):241-249. doi: 10.1016/j.ogc.2022.10.010. PMID: 36822707
Management of venous thromboembolism in pregnancy.
Kalaitzopoulos DR, Panagopoulos A, Samant S, Ghalib N, Kadillari J, Daniilidis A, Samartzis N, Makadia J, Palaiodimos L, Kokkinidis DG, Spyrou N
Thromb Res 2022 Mar;211:106-113. Epub 2022 Feb 7 doi: 10.1016/j.thromres.2022.02.002. PMID: 35149395
Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins–Obstetrics
Obstet Gynecol 2018 Jul;132(1):e18-e34. doi: 10.1097/AOG.0000000000002703. PMID: 29939939
ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Jul;132(1):e1-e17. doi: 10.1097/AOG.0000000000002706. PMID: 29939938

Prognosis

Maternal Mortality in Low and Middle-Income Countries.
Lawrence ER, Klein TJ, Beyuo TK
Obstet Gynecol Clin North Am 2022 Dec;49(4):713-733. doi: 10.1016/j.ogc.2022.07.001. PMID: 36328676
Peripartum Cardiomyopathy.
Farrell AS, Kuller JA, Goldstein SA, Dotters-Katz SK
Obstet Gynecol Surv 2021 Aug;76(8):485-492. doi: 10.1097/OGX.0000000000000903. PMID: 34449851
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Medical problems in pregnancy.
Narayan B, Nelson-Piercy C
Clin Med (Lond) 2017 Jun;17(3):251-257. doi: 10.7861/clinmedicine.17-3-251. PMID: 28572227Free PMC Article
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article

Clinical prediction guides

Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials.
Cheema HA, Ahmad AB, Ehsan M, Shahid A, Ayyan M, Azeem S, Hussain A, Shahid A, Nashwan AJ, Mikuš M, Laganà AS
Am J Obstet Gynecol MFM 2023 Aug;5(8):101049. Epub 2023 Jun 11 doi: 10.1016/j.ajogmf.2023.101049. PMID: 37311484
How Do We Treat Pregnancy-Related Venous Thromboembolism?
Linnemann B, Seelbach-Goebel B, Heimerl S, Hart C
Hamostaseologie 2020 Feb;40(1):54-63. Epub 2019 Nov 4 doi: 10.1055/s-0039-1700501. PMID: 31683346
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Postpartum Care and Contraception in Obese Women.
Maclean CC, Thompson IS
Clin Obstet Gynecol 2016 Mar;59(1):204-15. doi: 10.1097/GRF.0000000000000176. PMID: 26694498
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO
Chest 2012 Feb;141(2 Suppl):e691S-e736S. doi: 10.1378/chest.11-2300. PMID: 22315276Free PMC Article

Recent systematic reviews

Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials.
Cheema HA, Ahmad AB, Ehsan M, Shahid A, Ayyan M, Azeem S, Hussain A, Shahid A, Nashwan AJ, Mikuš M, Laganà AS
Am J Obstet Gynecol MFM 2023 Aug;5(8):101049. Epub 2023 Jun 11 doi: 10.1016/j.ajogmf.2023.101049. PMID: 37311484
Obstetric venous thromboembolism: a systematic review of dalteparin and pregnancy.
Hellgren M, Mistafa O
J Obstet Gynaecol 2019 May;39(4):439-450. Epub 2018 Nov 14 doi: 10.1080/01443615.2018.1499713. PMID: 30426808
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Incidence of venous thromboembolism during pregnancy and the puerperium: a systematic review and meta-analysis.
Meng K, Hu X, Peng X, Zhang Z
J Matern Fetal Neonatal Med 2015 Feb;28(3):245-53. Epub 2014 May 7 doi: 10.3109/14767058.2014.913130. PMID: 24716782

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