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Minimal Aneuploidy

MedGen UID:
821807
Concept ID:
C3829059
Cell or Molecular Dysfunction

Definition

A numerical chromosomal abnormality characterized by the presence of copy number variations in less than five percent of chromosomal arms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinimal Aneuploidy

Professional guidelines

PubMed

Leaver M, Wells D
Hum Reprod Update 2020 Jan 1;26(1):16-42. doi: 10.1093/humupd/dmz033. PMID: 31774124
Sparks TN, Caughey AB
Semin Perinatol 2018 Aug;42(5):275-282. Epub 2018 Jul 26 doi: 10.1053/j.semperi.2018.07.003. PMID: 30173949Free PMC Article
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423

Recent clinical studies

Etiology

Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML
J Clin Oncol 2024 Oct 10;42(29):3491-3503. Epub 2024 Aug 9 doi: 10.1200/JCO.23.02238. PMID: 39121442Free PMC Article
Seckin S, Forman EJ
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):216-223. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000865. PMID: 37185353
Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG
Blood 2021 Jan 28;137(4):471-484. doi: 10.1182/blood.2020006287. PMID: 32881995Free PMC Article
Leaver M, Wells D
Hum Reprod Update 2020 Jan 1;26(1):16-42. doi: 10.1093/humupd/dmz033. PMID: 31774124
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423

Diagnosis

Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML
J Clin Oncol 2024 Oct 10;42(29):3491-3503. Epub 2024 Aug 9 doi: 10.1200/JCO.23.02238. PMID: 39121442Free PMC Article
Widman AJ, Shah M, Frydendahl A, Halmos D, Khamnei CC, Øgaard N, Rajagopalan S, Arora A, Deshpande A, Hooper WF, Quentin J, Bass J, Zhang M, Langanay T, Andersen L, Steinsnyder Z, Liao W, Rasmussen MH, Henriksen TV, Jensen SØ, Nors J, Therkildsen C, Sotelo J, Brand R, Schiffman JS, Shah RH, Cheng AP, Maher C, Spain L, Krause K, Frederick DT, den Brok W, Lohrisch C, Shenkier T, Simmons C, Villa D, Mungall AJ, Moore R, Zaikova E, Cerda V, Kong E, Lai D, Malbari MS, Marton M, Manaa D, Winterkorn L, Gelmon K, Callahan MK, Boland G, Potenski C, Wolchok JD, Saxena A, Turajlic S, Imielinski M, Berger MF, Aparicio S, Altorki NK, Postow MA, Robine N, Andersen CL, Landau DA
Nat Med 2024 Jun;30(6):1655-1666. Epub 2024 Jun 14 doi: 10.1038/s41591-024-03040-4. PMID: 38877116Free PMC Article
Rubio C, Navarro-Sánchez L, García-Pascual CM, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahçeci M, Kulmann MIR, López L, De la Fuente E, Navarro R, Valbuena D, Sakkas D, Rienzi L, Simón C
Am J Obstet Gynecol 2020 Nov;223(5):751.e1-751.e13. Epub 2020 May 26 doi: 10.1016/j.ajog.2020.04.035. PMID: 32470458
Leaver M, Wells D
Hum Reprod Update 2020 Jan 1;26(1):16-42. doi: 10.1093/humupd/dmz033. PMID: 31774124
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423

Therapy

Vong KI, Lee S, Au KS, Crowley TB, Capra V, Martino J, Haller M, Araújo C, Machado HR, George R, Gerding B, James KN, Stanley V, Jiang N, Alu K, Meave N, Nidhiry AS, Jiwani F, Tang I, Nisal A, Jhamb I, Patel A, Patel A, McEvoy-Venneri J, Barrows C, Shen C, Ha YJ, Howarth R, Strain M, Ashley-Koch AE, Azam M, Mumtaz S, Bot GM, Finnell RH, Kibar Z, Marwan AI, Melikishvili G, Meltzer HS, Mutchinick OM, Stevenson DA, Mroczkowski HJ, Ostrander B, Schindewolf E, Moldenhauer J, Zackai EH, Emanuel BS, Garcia-Minaur S, Nowakowska BA, Stevenson RE, Zaki MS, Northrup H, McNamara HK, Aldinger KA, Phelps IG, Deng M, Glass IA; Spina Bifida Sequencing Consortium‡, Morrow B, McDonald-McGinn DM, Sanna-Cherchi S, Lamb DJ, Gleeson JG
Science 2024 May 3;384(6695):584-590. Epub 2024 May 2 doi: 10.1126/science.adl1624. PMID: 38696583
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A
Hum Reprod Update 2023 Sep 5;29(5):570-633. doi: 10.1093/humupd/dmad010. PMID: 37192834
Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG
Blood 2021 Jan 28;137(4):471-484. doi: 10.1182/blood.2020006287. PMID: 32881995Free PMC Article
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423
Tarlatzis BC, Zepiridis L
Ann N Y Acad Sci 2003 Nov;997:93-104. doi: 10.1196/annals.1290.011. PMID: 14644814

Prognosis

Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A
Hum Reprod Update 2023 Sep 5;29(5):570-633. doi: 10.1093/humupd/dmad010. PMID: 37192834
Yang L, Wei Z, Chen X, Hu L, Peng X, Wang J, Lu C, Kong Y, Dong X, Ni Q, Lu Y, Wu B, Wang H, Meirelles K, Tian X, Zhang J, Chang F, Liu L, Li C, You W, Cheng G, Wang L, Cao Y, Chen C, Fang P, Tang S, Zhou W
Clin Genet 2022 Jan;101(1):101-109. Epub 2021 Oct 25 doi: 10.1111/cge.14075. PMID: 34671977
Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG
Blood 2021 Jan 28;137(4):471-484. doi: 10.1182/blood.2020006287. PMID: 32881995Free PMC Article
Tarlatzis BC, Zepiridis L
Ann N Y Acad Sci 2003 Nov;997:93-104. doi: 10.1196/annals.1290.011. PMID: 14644814
Oscier DG, Gardiner AC
Best Pract Res Clin Haematol 2001 Sep;14(3):609-30. doi: 10.1053/beha.2001.0157. PMID: 11640872

Clinical prediction guides

Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A
Hum Reprod Update 2023 Sep 5;29(5):570-633. doi: 10.1093/humupd/dmad010. PMID: 37192834
Wallace A, Krishna Y, Coupland SE, Heimann H, Diafas A, Hussain RN
Ophthalmology 2023 Oct;130(10):1046-1052. Epub 2023 May 13 doi: 10.1016/j.ophtha.2023.05.009. PMID: 37182744
Yang L, Wei Z, Chen X, Hu L, Peng X, Wang J, Lu C, Kong Y, Dong X, Ni Q, Lu Y, Wu B, Wang H, Meirelles K, Tian X, Zhang J, Chang F, Liu L, Li C, You W, Cheng G, Wang L, Cao Y, Chen C, Fang P, Tang S, Zhou W
Clin Genet 2022 Jan;101(1):101-109. Epub 2021 Oct 25 doi: 10.1111/cge.14075. PMID: 34671977
Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG
Blood 2021 Jan 28;137(4):471-484. doi: 10.1182/blood.2020006287. PMID: 32881995Free PMC Article
Rubio C, Navarro-Sánchez L, García-Pascual CM, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahçeci M, Kulmann MIR, López L, De la Fuente E, Navarro R, Valbuena D, Sakkas D, Rienzi L, Simón C
Am J Obstet Gynecol 2020 Nov;223(5):751.e1-751.e13. Epub 2020 May 26 doi: 10.1016/j.ajog.2020.04.035. PMID: 32470458

Recent systematic reviews

Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A
Hum Reprod Update 2023 Sep 5;29(5):570-633. doi: 10.1093/humupd/dmad010. PMID: 37192834
Dviri M, Madjunkova S, Koziarz A, Madjunkov M, Mashiach J, Nekolaichuk E, Trivodaliev K, Al-Asmar N, Moskovtsev SI, Librach C
Hum Reprod Update 2021 Apr 21;27(3):486-500. doi: 10.1093/humupd/dmaa052. PMID: 33355342
Sagi-Dain L, Peleg A, Sagi S
Prenat Diagn 2017 Nov;37(11):1061-1066. Epub 2017 Oct 15 doi: 10.1002/pd.5160. PMID: 28944967
Beck-Fruchter R, Shalev E, Weiss A
Reprod Biomed Online 2016 Mar;32(3):286-98. Epub 2015 Dec 23 doi: 10.1016/j.rbmo.2015.12.001. PMID: 26776822
Akolekar R, Beta J, Picciarelli G, Ogilvie C, D'Antonio F
Ultrasound Obstet Gynecol 2015 Jan;45(1):16-26. doi: 10.1002/uog.14636. PMID: 25042845

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