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Mesenchymal glioblastoma

MedGen UID:
821870
•Concept ID:
C3829122
•
Neoplastic Process
Synonyms: glioblastoma mesenchymal subtype; Mesenchymal Glioblastoma; mesenchymal glioblastoma
 
Monarch Initiative: MONDO:0000459

Definition

A molecular subtype of glioblastoma characterized by the presence of NF1 mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesenchymal glioblastoma

Professional guidelines

PubMed

Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment.
Vo VTA, Kim S, Hua TNM, Oh J, Jeong Y
Commun Biol 2022 Jun 16;5(1):593. doi: 10.1038/s42003-022-03538-y. PMID: 35710828Free PMC Article

Recent clinical studies

Etiology

Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro.
Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females.
Bhawe K, Das JK, Yoo C, Felty Q, Gong Z, Deoraj A, Liuzzi JP, Ehtesham NZ, Hasnain SE, Singh VP, Mohapatra I, Komotar RJ, Roy D
J Cancer Res Clin Oncol 2022 Jul;148(7):1641-1682. Epub 2022 Apr 20 doi: 10.1007/s00432-022-03987-2. PMID: 35441887
ABCG1 maintains high-grade glioma survival in vitro and in vivo.
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH
Oncotarget 2016 Apr 26;7(17):23416-24. doi: 10.18632/oncotarget.8030. PMID: 26981778Free PMC Article
Gliomatosis cerebri: no evidence for a separate brain tumor entity.
Herrlinger U, Jones DTW, Glas M, Hattingen E, Gramatzki D, Stuplich M, Felsberg J, Bähr O, Gielen GH, Simon M, Wiewrodt D, Schabet M, Hovestadt V, Capper D, Steinbach JP, von Deimling A, Lichter P, Pfister SM, Weller M, Reifenberger G
Acta Neuropathol 2016 Feb;131(2):309-319. Epub 2015 Oct 22 doi: 10.1007/s00401-015-1495-z. PMID: 26493382
Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling.
Reifenberger G, Weber RG, Riehmer V, Kaulich K, Willscher E, Wirth H, Gietzelt J, Hentschel B, Westphal M, Simon M, Schackert G, Schramm J, Matschke J, Sabel MC, Gramatzki D, Felsberg J, Hartmann C, Steinbach JP, Schlegel U, Wick W, Radlwimmer B, Pietsch T, Tonn JC, von Deimling A, Binder H, Weller M, Loeffler M; German Glioma Network
Int J Cancer 2014 Oct 15;135(8):1822-31. Epub 2014 Mar 28 doi: 10.1002/ijc.28836. PMID: 24615357

Diagnosis

Dual p38MAPK and MEK inhibition disrupts adaptive chemoresistance in mesenchymal glioblastoma to temozolomide.
Cheng HS, Chong YK, Lim EKY, Lee XY, Pang QY, Novera W, Marvalim C, Lee JXT, Ang BT, Tang C, Tan NS
Neuro Oncol 2024 Jul 5;26(7):1247-1261. doi: 10.1093/neuonc/noae028. PMID: 38366847Free PMC Article
NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation.
Su IC, Su YK, Setiawan SA, Yadav VK, Fong IH, Yeh CT, Lin CM, Liu HW
Int J Mol Sci 2023 Apr 22;24(9) doi: 10.3390/ijms24097706. PMID: 37175412Free PMC Article
Aberrant L-Fucose Accumulation and Increased Core Fucosylation Are Metabolic Liabilities in Mesenchymal Glioblastoma.
Pieri V, Gallotti AL, Drago D, Cominelli M, Pagano I, Conti V, Valtorta S, Coliva A, Lago S, Michelatti D, Massimino L, Ungaro F, Perani L, Spinelli A, Castellano A, Falini A, Zippo A, Poliani PL, Moresco RM, Andolfo A, Galli R
Cancer Res 2023 Jan 18;83(2):195-218. doi: 10.1158/0008-5472.CAN-22-0677. PMID: 36409826
Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes.
Keller M, Blom M, Conze LL, Guo M, Hägerstrand D, Aspenström P
Sci Rep 2022 Jun 14;12(1):9838. doi: 10.1038/s41598-022-14063-7. PMID: 35701472Free PMC Article
The adaptive transition of glioblastoma stem cells and its implications on treatments.
Wang Z, Zhang H, Xu S, Liu Z, Cheng Q
Signal Transduct Target Ther 2021 Mar 23;6(1):124. doi: 10.1038/s41392-021-00491-w. PMID: 33753720Free PMC Article

Therapy

NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation.
Su IC, Su YK, Setiawan SA, Yadav VK, Fong IH, Yeh CT, Lin CM, Liu HW
Int J Mol Sci 2023 Apr 22;24(9) doi: 10.3390/ijms24097706. PMID: 37175412Free PMC Article
Characterization of transcriptome profile and clinical features of a novel immunotherapy target CD204 in diffuse glioma.
Yuan Y, Zhao Q, Zhao S, Zhang P, Zhao H, Li Z, Du Y, Tian X, Lu J
Cancer Med 2019 Jul;8(8):3811-3821. Epub 2019 May 29 doi: 10.1002/cam4.2312. PMID: 31140757Free PMC Article
MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.
Bell JB, Eckerdt FD, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, Platanias LC
Mol Cancer Res 2016 Oct;14(10):984-993. Epub 2016 Jun 30 doi: 10.1158/1541-7786.MCR-16-0172. PMID: 27364770Free PMC Article

Prognosis

Dual p38MAPK and MEK inhibition disrupts adaptive chemoresistance in mesenchymal glioblastoma to temozolomide.
Cheng HS, Chong YK, Lim EKY, Lee XY, Pang QY, Novera W, Marvalim C, Lee JXT, Ang BT, Tang C, Tan NS
Neuro Oncol 2024 Jul 5;26(7):1247-1261. doi: 10.1093/neuonc/noae028. PMID: 38366847Free PMC Article
Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro.
Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment.
Vo VTA, Kim S, Hua TNM, Oh J, Jeong Y
Commun Biol 2022 Jun 16;5(1):593. doi: 10.1038/s42003-022-03538-y. PMID: 35710828Free PMC Article
Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes.
Keller M, Blom M, Conze LL, Guo M, Hägerstrand D, Aspenström P
Sci Rep 2022 Jun 14;12(1):9838. doi: 10.1038/s41598-022-14063-7. PMID: 35701472Free PMC Article
Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target.
Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, Zhou S, Wang YA, Fuller GN, Huse J, Gilboa E, Kang N, Huang X, Verhaak R, Li S, Heimberger AB
J Clin Invest 2019 Jan 2;129(1):137-149. Epub 2018 Nov 19 doi: 10.1172/JCI121266. PMID: 30307407Free PMC Article

Clinical prediction guides

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.
Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK
J Clin Invest 2023 Mar 1;133(5) doi: 10.1172/JCI147087. PMID: 36856115Free PMC Article
Aberrant L-Fucose Accumulation and Increased Core Fucosylation Are Metabolic Liabilities in Mesenchymal Glioblastoma.
Pieri V, Gallotti AL, Drago D, Cominelli M, Pagano I, Conti V, Valtorta S, Coliva A, Lago S, Michelatti D, Massimino L, Ungaro F, Perani L, Spinelli A, Castellano A, Falini A, Zippo A, Poliani PL, Moresco RM, Andolfo A, Galli R
Cancer Res 2023 Jan 18;83(2):195-218. doi: 10.1158/0008-5472.CAN-22-0677. PMID: 36409826
Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro.
Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females.
Bhawe K, Das JK, Yoo C, Felty Q, Gong Z, Deoraj A, Liuzzi JP, Ehtesham NZ, Hasnain SE, Singh VP, Mohapatra I, Komotar RJ, Roy D
J Cancer Res Clin Oncol 2022 Jul;148(7):1641-1682. Epub 2022 Apr 20 doi: 10.1007/s00432-022-03987-2. PMID: 35441887
Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression.
Murata H, Yoshimoto K, Hatae R, Akagi Y, Mizoguchi M, Hata N, Kuga D, Nakamizo A, Amano T, Sayama T, Iihara K
J Neurooncol 2015 Oct;125(1):33-41. Epub 2015 Aug 14 doi: 10.1007/s11060-015-1886-y. PMID: 26272600

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