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End Organ Damage from Diabetes

MedGen UID:
823063
•Concept ID:
C3830315
•
Finding

Definition

Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes. The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnd Organ Damage from Diabetes

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Recent clinical studies

Etiology

Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Diagnosis

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Therapy

Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors.
Zheng W, Li H, Go Y, Chan XHF, Huang Q, Wu J
Nutrients 2022 Nov 1;14(21) doi: 10.3390/nu14214588. PMID: 36364850Free PMC Article
Classical and Nonclassical Manifestations of Primary Hyperparathyroidism.
El-Hajj Fuleihan G, Chakhtoura M, Cipriani C, Eastell R, Karonova T, Liu JM, Minisola S, Mithal A, Moreira CA, Peacock M, Schini M, Silva B, Walker M, El Zein O, Marcocci C
J Bone Miner Res 2022 Nov;37(11):2330-2350. Epub 2022 Oct 17 doi: 10.1002/jbmr.4679. PMID: 36245249
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Prognosis

Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management.
Dogra P, Bancos I, Young WF Jr
Mayo Clin Proc 2023 Aug;98(8):1207-1215. doi: 10.1016/j.mayocp.2023.04.023. PMID: 37536806
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial.
Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators, Yusuf S, Teo K, Anderson C, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P
Lancet 2008 Sep 27;372(9644):1174-83. Epub 2008 Aug 29 doi: 10.1016/S0140-6736(08)61242-8. PMID: 18757085

Clinical prediction guides

Classical and Nonclassical Manifestations of Primary Hyperparathyroidism.
El-Hajj Fuleihan G, Chakhtoura M, Cipriani C, Eastell R, Karonova T, Liu JM, Minisola S, Mithal A, Moreira CA, Peacock M, Schini M, Silva B, Walker M, El Zein O, Marcocci C
J Bone Miner Res 2022 Nov;37(11):2330-2350. Epub 2022 Oct 17 doi: 10.1002/jbmr.4679. PMID: 36245249
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article
Renal transplantation today.
Neipp M, Jackobs S, Klempnauer J
Langenbecks Arch Surg 2009 Jan;394(1):1-16. Epub 2008 May 14 doi: 10.1007/s00423-008-0335-1. PMID: 18478256

Recent systematic reviews

Clinical evidence for high-risk CE-marked medical devices for glucose management: A systematic review and meta-analysis.
Bano A, Künzler J, Wehrli F, Kastrati L, Rivero T, Llane A, Valz Gris A, Fraser AG, Stettler C, Hovorka R, Laimer M, Bally L; CORE‐MD investigators
Diabetes Obes Metab 2024 Oct;26(10):4753-4766. Epub 2024 Aug 14 doi: 10.1111/dom.15849. PMID: 39143655
The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review.
Nasimi Doost Azgomi R, Karimi A, Zarshenas MM, Moini Jazani A
Diabetes Metab Syndr 2022 Jan;16(1):102365. Epub 2021 Dec 14 doi: 10.1016/j.dsx.2021.102365. PMID: 34923214
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
A systematic review on the impact of diabetes mellitus on the ocular surface.
Shih KC, Lam KS, Tong L
Nutr Diabetes 2017 Mar 20;7(3):e251. doi: 10.1038/nutd.2017.4. PMID: 28319106Free PMC Article
Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.
Piccoli GB, Clari R, Ghiotto S, Castelluccia N, Colombi N, Mauro G, Tavassoli E, Melluzza C, Cabiddu G, Gernone G, Mongilardi E, Ferraresi M, Rolfo A, Todros T
Rev Diabet Stud 2013 Spring;10(1):6-26. Epub 2013 May 10 doi: 10.1900/RDS.2013.10.6. PMID: 24172695Free PMC Article

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