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Presenile dementia

MedGen UID:
8278
•Concept ID:
C0011265
•
Mental or Behavioral Dysfunction
Synonyms: Dementia, Presenile; Presenile Dementia
SNOMED CT: Presenile dementia (12348006)

Definition

The presence of dementia in an individual younger than age sixty five. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPresenile dementia

Professional guidelines

PubMed

Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Wong TH, Seelaar H, Melhem S, Rozemuller AJM, van Swieten JC
Neurobiol Aging 2020 Feb;86:201.e9-201.e14. Epub 2019 Jan 29 doi: 10.1016/j.neurobiolaging.2019.01.015. PMID: 30797548
Complete recovery from psychosis upon miglustat treatment in a juvenile Niemann-Pick C patient.
Szakszon K, Szegedi I, Magyar A, Oláh E, Andrejkovics M, Balla P, Lengyel A, Berényi E, Balogh I
Eur J Paediatr Neurol 2014 Jan;18(1):75-8. Epub 2013 Oct 1 doi: 10.1016/j.ejpn.2013.08.002. PMID: 24119781
Differential diagnosis of presenile dementia on clinical grounds.
Gustafson L, Nilsson L
Acta Psychiatr Scand 1982 Mar;65(3):194-209. doi: 10.1111/j.1600-0447.1982.tb00840.x. PMID: 7072512

Recent clinical studies

Etiology

COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US.
Wang Q, Davis PB, Gurney ME, Xu R
Alzheimers Dement 2021 Aug;17(8):1297-1306. Epub 2021 Feb 9 doi: 10.1002/alz.12296. PMID: 33559975Free PMC Article
Vascular cognitive impairment: A preventable component of dementia.
Azarpazhooh MR, Hachinski V
Handb Clin Neurol 2019;167:377-391. doi: 10.1016/B978-0-12-804766-8.00020-0. PMID: 31753144
Alzheimer Disease: Scientific Breakthroughs and Translational Challenges.
Caselli RJ, Beach TG, Knopman DS, Graff-Radford NR
Mayo Clin Proc 2017 Jun;92(6):978-994. doi: 10.1016/j.mayocp.2017.02.011. PMID: 28578785Free PMC Article
Rapidly progressive young-onset dementias: neuropsychiatric aspects.
Shrestha R, Wuerz T, Appleby BS
Psychiatr Clin North Am 2015 Jun;38(2):221-32. Epub 2015 Mar 2 doi: 10.1016/j.psc.2015.01.001. PMID: 25998112
Frontotemporal dementia--a brief review.
Sjögren M, Andersen C
Mech Ageing Dev 2006 Feb;127(2):180-7. Epub 2005 Dec 5 doi: 10.1016/j.mad.2005.09.015. PMID: 16330083

Diagnosis

Vascular cognitive impairment: A preventable component of dementia.
Azarpazhooh MR, Hachinski V
Handb Clin Neurol 2019;167:377-391. doi: 10.1016/B978-0-12-804766-8.00020-0. PMID: 31753144
Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
Rapidly progressive young-onset dementias: neuropsychiatric aspects.
Shrestha R, Wuerz T, Appleby BS
Psychiatr Clin North Am 2015 Jun;38(2):221-32. Epub 2015 Mar 2 doi: 10.1016/j.psc.2015.01.001. PMID: 25998112
Presenile dementia syndromes: an update on taxonomy and diagnosis.
Greicius MD, Geschwind MD, Miller BL
J Neurol Neurosurg Psychiatry 2002 Jun;72(6):691-700. doi: 10.1136/jnnp.72.6.691. PMID: 12023408Free PMC Article
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587

Therapy

Hashimoto's encephalopathy mimicking presenile dementia.
Goh KK, Chiu YH, Shen WW
Gen Hosp Psychiatry 2014 May-Jun;36(3):360.e9-11. Epub 2014 Jan 17 doi: 10.1016/j.genhosppsych.2014.01.006. PMID: 24559930
Organic solvents and presenile dementia (the painters' syndrome). A critical review of the Danish literature.
Errebo-Knudsen EO, Olsen F
Sci Total Environ 1986 Jan;48(1-2):45-67. doi: 10.1016/0048-9697(86)90153-1. PMID: 3511526
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587
Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.
Christie JE, Shering A, Ferguson J, Glen AI
Br J Psychiatry 1981 Jan;138:46-50. doi: 10.1192/bjp.138.1.46. PMID: 7023592
Brain aging and Alzheimer's disease.
Crapper DR, DeBoni U
Can Psychiatr Assoc J 1978 Jan;23(4):229-33. doi: 10.1177/070674377802300406. PMID: 667780

Prognosis

Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
Hashimoto's encephalopathy mimicking presenile dementia.
Goh KK, Chiu YH, Shen WW
Gen Hosp Psychiatry 2014 May-Jun;36(3):360.e9-11. Epub 2014 Jan 17 doi: 10.1016/j.genhosppsych.2014.01.006. PMID: 24559930
Presenile dementia syndromes: an update on taxonomy and diagnosis.
Greicius MD, Geschwind MD, Miller BL
J Neurol Neurosurg Psychiatry 2002 Jun;72(6):691-700. doi: 10.1136/jnnp.72.6.691. PMID: 12023408Free PMC Article
Utility of auditory P300 in detection of presenile dementia.
Filipović SR, Kostić VS
J Neurol Sci 1995 Aug;131(2):150-5. doi: 10.1016/0022-510x(95)00093-h. PMID: 7595640
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587

Clinical prediction guides

Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Wong TH, Seelaar H, Melhem S, Rozemuller AJM, van Swieten JC
Neurobiol Aging 2020 Feb;86:201.e9-201.e14. Epub 2019 Jan 29 doi: 10.1016/j.neurobiolaging.2019.01.015. PMID: 30797548
Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
CSF-tau and CSF-Abeta(1-42) in posterior cortical atrophy.
Baumann TP, Duyar H, Sollberger M, Kuhle J, Regeniter A, Gomez-Mancilla B, Schmidtke K, Monsch AU
Dement Geriatr Cogn Disord 2010;29(6):530-3. Epub 2010 Jul 1 doi: 10.1159/000314679. PMID: 20606434
Utility of auditory P300 in detection of presenile dementia.
Filipović SR, Kostić VS
J Neurol Sci 1995 Aug;131(2):150-5. doi: 10.1016/0022-510x(95)00093-h. PMID: 7595640
The clinical phenomenology of presenile dementia. A critical review of the literature.
Liston EH
J Nerv Ment Dis 1979 Jun;167(6):329-36. doi: 10.1097/00005053-197906000-00001. PMID: 376780

Recent systematic reviews

The role of brain perfusion SPECT in the diagnosis of frontotemporal dementia: A systematic review.
Athanasio BS, Oliveira ACS, Pedrosa AL, Borges RS, Neto AOM, Oliveira RA, de Resende EPF, de Moraes RF, Caramelli P, de Souza LC
J Neuroimaging 2024 May-Jun;34(3):308-319. Epub 2024 Jan 8 doi: 10.1111/jon.13189. PMID: 38192155

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