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Recurrent Renal Cell Carcinoma

MedGen UID:
82958
•Concept ID:
C0278679
•
Neoplastic Process
Synonyms: Relapsed Renal Cell Carcinoma; Renal Cell Carcinoma, Recurrent

Definition

A reemergence of renal cell carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Renal Cell Carcinoma

Professional guidelines

PubMed

Effects of Tyrosine Kinase Inhibitors on Blood Pressure in Patients with Unresectable or Advanced Recurrent Renal Cell Carcinoma-Bayes-Mixed Treatment Comparison Meta-Analysis.
Yamaguchi S, Murayama R, Satoh E, Inoue T, Ise Y
Gan To Kagaku Ryoho 2021 Sep;48(9):1145-1151. PMID: 34521793
Clinical utility of (68)Ga-DOTATOC positron emission tomography/computed tomography for recurrent renal cell carcinoma.
Nakamoto Y, Ishimori T, Shimizu Y, Sano K, Togashi K
Eur J Nucl Med Mol Imaging 2019 Jul;46(7):1524-1530. Epub 2019 Mar 7 doi: 10.1007/s00259-019-04298-4. PMID: 30847538
Treatment of recurrent or metastatic renal cell carcinoma.
Shah RN, Ahmad T, Eisen TG
Expert Rev Anticancer Ther 2004 Dec;4(6):1069-80. doi: 10.1586/14737140.4.6.1069. PMID: 15606334

Recent clinical studies

Etiology

Molecular characterization of renal cell carcinoma tumors from a phase III anti-angiogenic adjuvant therapy trial.
Motzer RJ, Martini JF, Mu XJ, Staehler M, George DJ, Valota O, Lin X, Pandha HS, Ching KA, Ravaud A
Nat Commun 2022 Oct 10;13(1):5959. doi: 10.1038/s41467-022-33555-8. PMID: 36216827Free PMC Article
Gastrointestinal Involvement of Recurrent Renal Cell Carcinoma: CT Findings and Clinicopathologic Features.
Park HJ, Kim HJ, Park SH, Lee JS, Kim AY, Ha HK
Korean J Radiol 2017 May-Jun;18(3):452-460. Epub 2017 Apr 3 doi: 10.3348/kjr.2017.18.3.452. PMID: 28458597Free PMC Article
Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data.
Speed JM, Trinh QD, Choueiri TK, Sun M
Curr Urol Rep 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3. PMID: 28213859
Salvage Percutaneous Cryoablation for Locally Recurrent Renal-Cell Carcinoma After Primary Cryoablation.
Okhunov Z, Chamberlin J, Moreira DM, George A, Babaian K, Shah P, Youssef R, Kaler KS, Lobko II, Kavoussi L, Landman J
J Endourol 2016 Jun;30(6):632-7. Epub 2016 Apr 22 doi: 10.1089/end.2016.0088. PMID: 27009377
Diagnosis of recurrent renal cell carcinoma following segmental and laparoscopic resection of multiphase spiral computerized tomography.
Lang EK, Gupta N, Davis R, Macchia R
J Urol 2006 Apr;175(4):1503. doi: 10.1016/S0022-5347(06)00062-0. PMID: 16516036

Diagnosis

Benign splenic regrowth mistaken as recurrent renal cell carcinoma.
McAlpine K, Breau RH
CMAJ 2019 Dec 9;191(49):E1355-E1357. doi: 10.1503/cmaj.191128. PMID: 31818928Free PMC Article
Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data.
Speed JM, Trinh QD, Choueiri TK, Sun M
Curr Urol Rep 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3. PMID: 28213859
Contrast Enhanced Ultrasound Detects Recurrent Renal Cell Carcinoma in the Setting of Chronic Renal Insufficiency.
Tzou DT, Weinstein S, Usawachintachit M, Mongan J, Greene KL, Chi T
Clin Genitourin Cancer 2017 Aug;15(4):e735-e737. Epub 2016 Dec 13 doi: 10.1016/j.clgc.2016.12.010. PMID: 28131753Free PMC Article
Uveal metastasis and myasthenia gravis in a patient with recurrent renal cell carcinoma treated with pazopanib.
Jebb A, Hadden P, Broom RJ
Clin Genitourin Cancer 2014 Aug;12(4):e143-6. Epub 2014 Feb 21 doi: 10.1016/j.clgc.2014.02.002. PMID: 24656526
Diagnosis of recurrent renal cell carcinoma following segmental and laparoscopic resection of multiphase spiral computerized tomography.
Lang EK, Gupta N, Davis R, Macchia R
J Urol 2006 Apr;175(4):1503. doi: 10.1016/S0022-5347(06)00062-0. PMID: 16516036

Therapy

Molecular characterization of renal cell carcinoma tumors from a phase III anti-angiogenic adjuvant therapy trial.
Motzer RJ, Martini JF, Mu XJ, Staehler M, George DJ, Valota O, Lin X, Pandha HS, Ching KA, Ravaud A
Nat Commun 2022 Oct 10;13(1):5959. doi: 10.1038/s41467-022-33555-8. PMID: 36216827Free PMC Article
Recurrent renal cell carcinoma following nephrectomy and ablation therapy: Radiology perspective.
Ali O, Fishman EK, Kawamoto S
Eur J Radiol 2018 Oct;107:134-142. Epub 2018 May 3 doi: 10.1016/j.ejrad.2018.05.002. PMID: 30292257
Uveal metastasis and myasthenia gravis in a patient with recurrent renal cell carcinoma treated with pazopanib.
Jebb A, Hadden P, Broom RJ
Clin Genitourin Cancer 2014 Aug;12(4):e143-6. Epub 2014 Feb 21 doi: 10.1016/j.clgc.2014.02.002. PMID: 24656526
Surgical management of locally recurrent renal cell carcinoma post-renal cryoablation: importance of stringent selection criteria.
Spiess PE
Urol Oncol 2010 May-Jun;28(3):241-2. Epub 2010 Mar 2 doi: 10.1016/j.urolonc.2009.12.007. PMID: 20189841
Treatment of recurrent or metastatic renal cell carcinoma.
Shah RN, Ahmad T, Eisen TG
Expert Rev Anticancer Ther 2004 Dec;4(6):1069-80. doi: 10.1586/14737140.4.6.1069. PMID: 15606334

Prognosis

Recurrent renal cell carcinoma following nephrectomy and ablation therapy: Radiology perspective.
Ali O, Fishman EK, Kawamoto S
Eur J Radiol 2018 Oct;107:134-142. Epub 2018 May 3 doi: 10.1016/j.ejrad.2018.05.002. PMID: 30292257
Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data.
Speed JM, Trinh QD, Choueiri TK, Sun M
Curr Urol Rep 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3. PMID: 28213859
Hypoglycemia Caused by Recurrent Renal Cell Carcinoma As Result of Production of High Molecular Weight Insulin-Like Growth Factor 2.
Kimura S, Mitsuzuka K, Yamada S, Kaiho Y, Watanabe M, Ikeda Y, Chiba K, Arai Y
J Clin Oncol 2016 May 1;34(13):e120-2. Epub 2014 Apr 7 doi: 10.1200/JCO.2013.49.5374. PMID: 24711554
Uveal metastasis and myasthenia gravis in a patient with recurrent renal cell carcinoma treated with pazopanib.
Jebb A, Hadden P, Broom RJ
Clin Genitourin Cancer 2014 Aug;12(4):e143-6. Epub 2014 Feb 21 doi: 10.1016/j.clgc.2014.02.002. PMID: 24656526
Diagnosis of recurrent renal cell carcinoma following segmental and laparoscopic resection of multiphase spiral computerized tomography.
Lang EK, Gupta N, Davis R, Macchia R
J Urol 2006 Apr;175(4):1503. doi: 10.1016/S0022-5347(06)00062-0. PMID: 16516036

Clinical prediction guides

Molecular characterization of renal cell carcinoma tumors from a phase III anti-angiogenic adjuvant therapy trial.
Motzer RJ, Martini JF, Mu XJ, Staehler M, George DJ, Valota O, Lin X, Pandha HS, Ching KA, Ravaud A
Nat Commun 2022 Oct 10;13(1):5959. doi: 10.1038/s41467-022-33555-8. PMID: 36216827Free PMC Article
Single-cell transcriptomics reveals a low CD8(+) T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma.
Peng YL, Xiong LB, Zhou ZH, Ning K, Li Z, Wu ZS, Deng MH, Wei WS, Wang N, Zou XP, He ZS, Huang JW, Luo JH, Liu JY, Jia N, Cao Y, Han H, Guo SJ, Dong P, Yu CP, Zhou FJ, Zhang ZL
J Immunother Cancer 2022 Feb;10(2) doi: 10.1136/jitc-2021-004206. PMID: 35121646Free PMC Article
Developments in urologic oncology "OncoForum": The best of 2017.
Gómez-Veiga F, Alcaraz-Asensio A, Burgos-Revilla J, Cózar-Olmo J
Actas Urol Esp (Engl Ed) 2018 Oct;42(8):488-498. Epub 2018 Jun 21 doi: 10.1016/j.acuro.2018.06.001. PMID: 29935800
Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data.
Speed JM, Trinh QD, Choueiri TK, Sun M
Curr Urol Rep 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3. PMID: 28213859
Recurrent renal cell carcinoma: clinical and prognostic value of FDG PET/CT.
Alongi P, Picchio M, Zattoni F, Spallino M, Gianolli L, Saladini G, Evangelista L
Eur J Nucl Med Mol Imaging 2016 Mar;43(3):464-73. Epub 2015 Aug 14 doi: 10.1007/s00259-015-3159-6. PMID: 26268680

Recent systematic reviews

Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data.
Speed JM, Trinh QD, Choueiri TK, Sun M
Curr Urol Rep 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3. PMID: 28213859

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