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Recurrent Retinoblastoma

MedGen UID:
82965
•Concept ID:
C0278720
•
Neoplastic Process
Synonym: Relapsed Retinoblastoma

Definition

The reemergence of retinoblastoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Retinoblastoma

Professional guidelines

PubMed

Intra-arterial chemotherapy for retinoblastoma treatment in Chile: Experience and results 2013-2020.
Oporto JI, Zúñiga P, Ossandón D, Zanolli M, Pérez V, López JP, Stetcher X, Rodríguez A, Puentes Á, Rustom S, Lobos J
Arch Soc Esp Oftalmol (Engl Ed) 2021 Jun;96(6):288-292. Epub 2021 Feb 27 doi: 10.1016/j.oftale.2020.10.003. PMID: 34092282
A Review of Recurrent Retinoblastoma: Children's Hospital Los Angeles Classification and Treatment Guidelines.
Berry JL, Kogachi K, Murphree AL, Jubran R, Kim JW
Int Ophthalmol Clin 2019 Spring;59(2):65-75. doi: 10.1097/IIO.0000000000000269. PMID: 30908280Free PMC Article
OCT-guided management of subclinical recurrent retinoblastoma.
Gaillard MC, Houghton S, Stathopoulos C, Munier FL
Ophthalmic Genet 2018 Jun;39(3):338-343. Epub 2018 Feb 9 doi: 10.1080/13816810.2018.1436183. PMID: 29424610

Recent clinical studies

Etiology

Outcome of salvage intra-arterial chemotherapy for recurrent retinoblastoma.
Li J, Jing C, Hua X, Liang T, Li J, Zhao P, Ji X
Eye (Lond) 2022 Nov;36(11):2106-2110. Epub 2021 Oct 15 doi: 10.1038/s41433-021-01693-w. PMID: 34654891Free PMC Article
Risk factors for recurrent retinoblastoma after intravenous chemotherapy.
Kaliki S, Vempuluru VS, Priya Y, Mohamed A
Int Ophthalmol 2021 Jun;41(6):2033-2039. Epub 2021 Feb 20 doi: 10.1007/s10792-021-01759-4. PMID: 33611762
Applications of iodine-125 plaque radiotherapy for residual or recurrent retinoblastoma.
Soliman SE, Bansal A, De Nicola ML, Bhambhwani V, Laperriere N, Gallie BL, Krema H
Can J Ophthalmol 2021 Oct;56(5):317-324. Epub 2021 Jan 23 doi: 10.1016/j.jcjo.2020.12.016. PMID: 33493457
OCT-guided management of subclinical recurrent retinoblastoma.
Gaillard MC, Houghton S, Stathopoulos C, Munier FL
Ophthalmic Genet 2018 Jun;39(3):338-343. Epub 2018 Feb 9 doi: 10.1080/13816810.2018.1436183. PMID: 29424610
Periocular topotecan for intraocular retinoblastoma.
Mallipatna AC, Dimaras H, Chan HS, Héon E, Gallie BL
Arch Ophthalmol 2011 Jun;129(6):738-45. doi: 10.1001/archophthalmol.2011.130. PMID: 21670340

Diagnosis

Risk factors for recurrent retinoblastoma after intravenous chemotherapy.
Kaliki S, Vempuluru VS, Priya Y, Mohamed A
Int Ophthalmol 2021 Jun;41(6):2033-2039. Epub 2021 Feb 20 doi: 10.1007/s10792-021-01759-4. PMID: 33611762
A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma.
Saengwimol D, Rojanaporn D, Chaitankar V, Chittavanich P, Aroonroch R, Boontawon T, Thammachote W, Jinawath N, Hongeng S, Kaewkhaw R
Sci Rep 2018 Oct 23;8(1):15664. doi: 10.1038/s41598-018-34037-y. PMID: 30353124Free PMC Article
Detection of Minimally Visible Recurrent Retinoblastoma by Hand-held Spectral-Domain Optical Coherence Tomography.
Gonzalez-Montpetit ME, Samara WA, Magrath GN, Shields CL
J Pediatr Ophthalmol Strabismus 2017 Feb 14;54:e6-e8. doi: 10.3928/01913913-20170201-03. PMID: 28196267
Very late relapse of bilateral retinoblastoma.
Choi JY, Kang HJ, Lee JW, Ju HY, Hong CR, Kim H, Yu YS, Park SH, Cheon JE, Park KD, Shin HY
J Pediatr Hematol Oncol 2015 May;37(4):e264-7. doi: 10.1097/MPH.0000000000000310. PMID: 25757022
Periocular topotecan for intraocular retinoblastoma.
Mallipatna AC, Dimaras H, Chan HS, Héon E, Gallie BL
Arch Ophthalmol 2011 Jun;129(6):738-45. doi: 10.1001/archophthalmol.2011.130. PMID: 21670340

Therapy

Outcome of salvage intra-arterial chemotherapy for recurrent retinoblastoma.
Li J, Jing C, Hua X, Liang T, Li J, Zhao P, Ji X
Eye (Lond) 2022 Nov;36(11):2106-2110. Epub 2021 Oct 15 doi: 10.1038/s41433-021-01693-w. PMID: 34654891Free PMC Article
A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma.
Saengwimol D, Rojanaporn D, Chaitankar V, Chittavanich P, Aroonroch R, Boontawon T, Thammachote W, Jinawath N, Hongeng S, Kaewkhaw R
Sci Rep 2018 Oct 23;8(1):15664. doi: 10.1038/s41598-018-34037-y. PMID: 30353124Free PMC Article
Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: preliminary results.
Shields CL, Manjandavida FP, Arepalli S, Kaliki S, Lally SE, Shields JA
JAMA Ophthalmol 2014 Mar;132(3):319-25. doi: 10.1001/jamaophthalmol.2013.7666. PMID: 24407202
Management of advanced retinoblastoma with intravenous chemotherapy then intra-arterial chemotherapy as alternative to enucleation.
Shields CL, Kaliki S, Al-Dahmash S, Rojanaporn D, Leahey A, Griffin G, Jabbour P, Shields JA
Retina 2013 Nov-Dec;33(10):2103-9. doi: 10.1097/IAE.0b013e318295f783. PMID: 23873161
Periocular topotecan for intraocular retinoblastoma.
Mallipatna AC, Dimaras H, Chan HS, Héon E, Gallie BL
Arch Ophthalmol 2011 Jun;129(6):738-45. doi: 10.1001/archophthalmol.2011.130. PMID: 21670340

Prognosis

Outcome of salvage intra-arterial chemotherapy for recurrent retinoblastoma.
Li J, Jing C, Hua X, Liang T, Li J, Zhao P, Ji X
Eye (Lond) 2022 Nov;36(11):2106-2110. Epub 2021 Oct 15 doi: 10.1038/s41433-021-01693-w. PMID: 34654891Free PMC Article
Risk factors for recurrent retinoblastoma after intravenous chemotherapy.
Kaliki S, Vempuluru VS, Priya Y, Mohamed A
Int Ophthalmol 2021 Jun;41(6):2033-2039. Epub 2021 Feb 20 doi: 10.1007/s10792-021-01759-4. PMID: 33611762
OCT-guided management of subclinical recurrent retinoblastoma.
Gaillard MC, Houghton S, Stathopoulos C, Munier FL
Ophthalmic Genet 2018 Jun;39(3):338-343. Epub 2018 Feb 9 doi: 10.1080/13816810.2018.1436183. PMID: 29424610
Periocular topotecan for intraocular retinoblastoma.
Mallipatna AC, Dimaras H, Chan HS, Héon E, Gallie BL
Arch Ophthalmol 2011 Jun;129(6):738-45. doi: 10.1001/archophthalmol.2011.130. PMID: 21670340
New and recurrent tumors in germinal retinoblastoma: is there a treatment effect?
Merrill PT, Buckley EG, Halperin EC
Ophthalmic Genet 1996 Sep;17(3):115-8. doi: 10.3109/13816819609057114. PMID: 8905852

Clinical prediction guides

Characteristics of patients with recurrent retinoblastoma: a survival analysis.
Li N, Wang YZ, Zhang Y, Zhang WL, Huang DS
BMC Cancer 2024 Mar 4;24(1):287. doi: 10.1186/s12885-024-12058-3. PMID: 38438837Free PMC Article
Risk factors for recurrent retinoblastoma after intravenous chemotherapy.
Kaliki S, Vempuluru VS, Priya Y, Mohamed A
Int Ophthalmol 2021 Jun;41(6):2033-2039. Epub 2021 Feb 20 doi: 10.1007/s10792-021-01759-4. PMID: 33611762
Applications of iodine-125 plaque radiotherapy for residual or recurrent retinoblastoma.
Soliman SE, Bansal A, De Nicola ML, Bhambhwani V, Laperriere N, Gallie BL, Krema H
Can J Ophthalmol 2021 Oct;56(5):317-324. Epub 2021 Jan 23 doi: 10.1016/j.jcjo.2020.12.016. PMID: 33493457
Periocular topotecan for intraocular retinoblastoma.
Mallipatna AC, Dimaras H, Chan HS, Héon E, Gallie BL
Arch Ophthalmol 2011 Jun;129(6):738-45. doi: 10.1001/archophthalmol.2011.130. PMID: 21670340
Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleation.
Gündüz K, Günalp I, Yalçindağ N, Unal E, Taçyildiz N, Erden E, Geyik PO
Ophthalmology 2004 Oct;111(10):1917-24. doi: 10.1016/j.ophtha.2004.04.016. PMID: 15465557

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