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Growth hormone-producing pituitary gland adenoma

MedGen UID:
82999
•Concept ID:
C0278864
•
Neoplastic Process
Synonym: Somatotrophinoma
 
Monarch Initiative: MONDO:0006238
Orphanet: ORPHA96256

Definition

An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly. [from MONDO]

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent clinical studies

Etiology

Acromegaly: Medical and Surgical Considerations.
Giantini-Larsen AM, Uribe-Cardenas R, Juthani RG
Otolaryngol Clin North Am 2022 Apr;55(2):331-341. Epub 2022 Mar 4 doi: 10.1016/j.otc.2021.12.007. PMID: 35256175
The clinical aspects of pituitary tumour genetics.
Dénes J, Korbonits M
Endocrine 2021 Mar;71(3):663-674. Epub 2021 Feb 4 doi: 10.1007/s12020-021-02633-0. PMID: 33543431Free PMC Article
Surgical treatment of aggressive pituitary adenomas and pituitary carcinomas.
Buchfelder M, Schlaffer SM
Rev Endocr Metab Disord 2020 Jun;21(2):253-261. doi: 10.1007/s11154-020-09563-8. PMID: 32500483Free PMC Article
Molecular Biology of Pituitary Adenomas.
Faltermeier CM, Magill ST, Blevins LS Jr, Aghi MK
Neurosurg Clin N Am 2019 Oct;30(4):391-400. Epub 2019 Jul 5 doi: 10.1016/j.nec.2019.05.001. PMID: 31471046
Excessive growth.
Narayanaswamy V, Rettig KR, Bhowmick SK
Clin Pediatr (Phila) 2008 Sep;47(7):705-8. Epub 2008 Jul 14 doi: 10.1177/0009922807311740. PMID: 18626098

Diagnosis

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Pituitary-Tumor Endocrinopathies.
Melmed S
N Engl J Med 2020 Mar 5;382(10):937-950. doi: 10.1056/NEJMra1810772. PMID: 32130815
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Acromegaly pathogenesis and treatment.
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Pediatric pituitary adenomas.
Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D
Childs Nerv Syst 2019 Nov;35(11):2107-2118. Epub 2019 Jul 13 doi: 10.1007/s00381-019-04293-y. PMID: 31302729
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Acromegaly.
Chanson P, Salenave S, Kamenicky P
Handb Clin Neurol 2014;124:197-219. doi: 10.1016/B978-0-444-59602-4.00014-9. PMID: 25248589

Prognosis

Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.
Bianchi A, Chiloiro S, Giampietro A, Gaudino S, Calandrelli R, Mazzarella C, Caldarella C, Rigante M, Gessi M, Lauretti L, De Marinis L, Olivi A, Pontecorvi A, Doglietto F
Front Endocrinol (Lausanne) 2023;14:1123267. Epub 2023 May 3 doi: 10.3389/fendo.2023.1123267. PMID: 37206441Free PMC Article
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly.
Chanson P, Salenave S, Kamenicky P
Handb Clin Neurol 2014;124:197-219. doi: 10.1016/B978-0-444-59602-4.00014-9. PMID: 25248589
Pituitary tumours: acromegaly.
Chanson P, Salenave S, Kamenicky P, Cazabat L, Young J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):555-74. doi: 10.1016/j.beem.2009.05.010. PMID: 19945023

Clinical prediction guides

Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.
Bianchi A, Chiloiro S, Giampietro A, Gaudino S, Calandrelli R, Mazzarella C, Caldarella C, Rigante M, Gessi M, Lauretti L, De Marinis L, Olivi A, Pontecorvi A, Doglietto F
Front Endocrinol (Lausanne) 2023;14:1123267. Epub 2023 May 3 doi: 10.3389/fendo.2023.1123267. PMID: 37206441Free PMC Article
Modern approach to resistant acromegaly.
Giustina A, di Filippo L, Uygur MM, Frara S
Endocrine 2023 May;80(2):303-307. Epub 2023 Feb 15 doi: 10.1007/s12020-023-03317-7. PMID: 36790521
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent systematic reviews

Efficacy and safety of radiosurgery in acromegaly.
Albano L, Losa M, Garbin E, Pompeo E, Barzaghi LR, Mortini P
Best Pract Res Clin Endocrinol Metab 2024 Jul;38(4):101898. Epub 2024 Apr 29 doi: 10.1016/j.beem.2024.101898. PMID: 38806304
Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.
Ogando-Rivas E, Alalade AF, Boatey J, Schwartz TH
Pituitary 2017 Dec;20(6):702-708. doi: 10.1007/s11102-017-0826-6. PMID: 28766078
Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
Briceno V, Zaidi HA, Doucette JA, Onomichi KB, Alreshidi A, Mekary RA, Smith TR
Neurol Res 2017 May;39(5):387-398. Epub 2017 Mar 16 doi: 10.1080/01616412.2017.1296653. PMID: 28301972
Endoscopic Endonasal versus Microsurgical Transsphenoidal Approach for Growth Hormone-Secreting Pituitary Adenomas-Systematic Review and Meta-Analysis.
Phan K, Xu J, Reddy R, Kalakoti P, Nanda A, Fairhall J
World Neurosurg 2017 Jan;97:398-406. Epub 2016 Oct 15 doi: 10.1016/j.wneu.2016.10.029. PMID: 27756664

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