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Clear cell acanthoma

MedGen UID:
83098
•Concept ID:
C0333992
•
Neoplastic Process
Synonyms: Acanthoma, Clear Cell; Acanthoma, Degos; Acanthomas, Clear Cell; Clear Cell Acanthoma; Clear Cell Acanthomas; Degos Acanthoma
SNOMED CT: Clear cell acanthoma (65540008); Clear cell acanthoma (254670002); Clear cell acanthoma of Degos (254670002); Degos' acanthoma (254670002)
 
Monarch Initiative: MONDO:0002086

Definition

An acanthoma characterized by the presence of psoriasiform epidermal acanthosis and basal cells with pale cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell acanthoma

Professional guidelines

PubMed

Comparative study of treatment methods for benign lichenoid keratosis of the face.
Yoon JH, Baek EJ, Park EJ, Kim KH
Dermatol Ther 2022 May;35(5):e15419. Epub 2022 Mar 12 doi: 10.1111/dth.15419. PMID: 35246904
Lesions With an Epidermal Hyperplastic Pattern: Morphologic Clues in the Differential Diagnosis.
Fernandez-Flores A
Am J Dermatopathol 2016 Jan;38(1):1-16; quiz 17-9. doi: 10.1097/DAD.0000000000000324. PMID: 26730692
Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.
Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908

Recent clinical studies

Etiology

Clear Cell Acanthoma: A Series of 70 Cases.
Marcoval J, Moreno-Vílchez C, Torrecilla-Vall-Llossera C, Muntaner-Virgili C, Penín RM
Actas Dermosifiliogr 2023 Sep;114(8):668-673. Epub 2023 Apr 29 doi: 10.1016/j.ad.2023.04.028. PMID: 37127205
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
Kuo KL, Lo CS, Lee LY, Yang CH, Kuo TT
J Am Acad Dermatol 2019 Mar;80(3):749-755. Epub 2018 Dec 14 doi: 10.1016/j.jaad.2016.07.032. PMID: 30558902
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.
Morrison LK, Duffey M, Janik M, Shamma HN
Int J Dermatol 2010 Sep;49(9):1008-11. doi: 10.1111/j.1365-4632.2010.04521.x. PMID: 20931670
Psoriasis-like dermoscopic pattern of clear cell acanthoma.
Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460

Diagnosis

Clear cell acanthoma.
Wagner G, Back W, Sachse MM
J Dtsch Dermatol Ges 2021 Jan;19(1):31-36. Epub 2020 Sep 28 doi: 10.1111/ddg.14270. PMID: 32989899
A Strand on Strings of Pearls.
Klimas NK
J Cutan Med Surg 2018 Nov/Dec;22(6):646. doi: 10.1177/1203475418782134. PMID: 30322296
Clear Cell Acanthoma of the Areola and Nipple.
Hidalgo-García Y, Gonzálvo P, Mallo-García S, Fernández-Sánchez C
Actas Dermosifiliogr 2016 Nov;107(9):793-795. Epub 2016 May 17 doi: 10.1016/j.ad.2016.04.008. PMID: 27206609
Multiple clear-cell acanthomas.
Martínez Escanamé M, Arzberger E, Hofmann-Wellenhof R, Massone C
Australas J Dermatol 2015 May;56(2):e46-8. Epub 2013 Aug 29 doi: 10.1111/ajd.12099. PMID: 23991751
Clear cell acanthoma.
Portal C, Fang F, Kanner W, Wilson B
Cutis 2013 Aug;92(2):62,77-9. PMID: 24087787

Therapy

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.
Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268
Clear Cell Acanthoma: Sural Nerve Entrapment and Neuropathy After Excision.
Bennett M, Sinclair R
Dermatol Surg 2021 Nov 1;47(11):1534-1535. doi: 10.1097/DSS.0000000000003234. PMID: 34608085
Eczematous, Pruritic, Brownish Plaque of the Nipple and Areola: A Quiz.
Orlando G, Linder D, Piaserico S, Alaibac M, Salmaso R
Acta Derm Venereol 2019 Dec 1;99(13):1317-1318. doi: 10.2340/00015555-3328. PMID: 31580462
Clear Cell Acanthoma of the Areola and Nipple.
Hidalgo-García Y, Gonzálvo P, Mallo-García S, Fernández-Sánchez C
Actas Dermosifiliogr 2016 Nov;107(9):793-795. Epub 2016 May 17 doi: 10.1016/j.ad.2016.04.008. PMID: 27206609
Multiple clear-cell acanthoma (Degos): histochemical and ultrastructural study of two cases.
Desmons F, Breuillard F, Thomas P, Leonardelli J, Hildebrand HF
Int J Dermatol 1977 Apr;16(3):203-13. doi: 10.1111/j.1365-4362.1977.tb01853.x. PMID: 852926

Prognosis

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.
Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases.
Veiga RR, Barros RS, Santos JE, Abreu Junior JM, Bittencourt Mde J, Miranda MF
An Bras Dermatol 2013 Jan-Feb;88(1):84-9. doi: 10.1590/s0365-05962013000100010. PMID: 23539008Free PMC Article
Clear cell acanthoma successfully treated with a carbon dioxide laser.
Chi CC, Wang SH, Huang HS
Dermatol Surg 2005 Oct;31(10):1355-8. doi: 10.1111/j.1524-4725.2005.31220. PMID: 16188196
Psoriasis-like dermoscopic pattern of clear cell acanthoma.
Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460
Polypoid clear cell acanthoma: case report.
Inalöz HS, Patel G, Knight AG
J Eur Acad Dermatol Venereol 2000 Nov;14(6):511-2. doi: 10.1046/j.1468-3083.2000.00141.x. PMID: 11444278

Clinical prediction guides

Unusual Eczematous Dermatitis on the Nipple and Areola in a Young Man with Clear Cell Acanthoma.
Daguer DEP, Ordoñez TF, Mazzuoccolo LD
Skinmed 2024;22(5):380-381. Epub 2024 Oct 22 PMID: 39433525
Clear Cell Acanthoma on the Areola.
Borda LJ, Mervis JS, Romanelli P, Lev-Tov H
Dermatol Online J 2018 Jul 15;24(7) PMID: 30261576
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma.
Scanni G, Pellacani G
An Bras Dermatol 2014 Sep-Oct;89(5):803-5. doi: 10.1590/abd1806-4841.20143079. PMID: 25184922Free PMC Article
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Psoriasis-like dermoscopic pattern of clear cell acanthoma.
Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460

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