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Adenocarcinoid tumor

MedGen UID:
83124
•Concept ID:
C0334302
•
Neoplastic Process
Synonym: Combined carcinoid and adenocarcinoma
SNOMED CT: Mixed carcinoid-adenocarcinoma (51465000); Mixed adenoneuroendocrine carcinoma (51465000); MANEC - mixed adenoneuroendocrine carcinoma (51465000); Composite carcinoid (51465000); Combined carcinoid and adenocarcinoma (51465000)
 
Monarch Initiative: MONDO:0021659

Definition

A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoid tumor

Professional guidelines

PubMed

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Baudin E, Caplin M, Garcia-Carbonero R, Fazio N, Ferolla P, Filosso PL, Frilling A, de Herder WW, Hörsch D, Knigge U, Korse CM, Lim E, Lombard-Bohas C, Pavel M, Scoazec JY, Sundin A, Berruti A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Apr;32(4):439-451. Epub 2021 Jan 19 doi: 10.1016/j.annonc.2021.01.003. PMID: 33482246
Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Principles of diagnosis and management of neuroendocrine tumours.
Raphael MJ, Chan DL, Law C, Singh S
CMAJ 2017 Mar 13;189(10):E398-E404. doi: 10.1503/cmaj.160771. PMID: 28385820Free PMC Article

Recent clinical studies

Etiology

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Oncological impact of laparoscopic lymphadenectomy with preservation of the left colic artery for advanced sigmoid and rectosigmoid colon cancer.
Yamamoto M, Okuda J, Tanaka K, Ishii M, Hamamoto H, Uchiyama K
Dig Surg 2014;31(6):452-8. Epub 2015 Jan 14 doi: 10.1159/000369938. PMID: 25592389
Pathology of gastric cancer and its precursor lesions.
Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640
Krukenberg tumor of the ovary from an occult appendiceal primary: case report and literature review.
Thomas R, Barnhill D, Worsham F, Hoskins W
Obstet Gynecol 1985 Mar;65(3 Suppl):95S-98S. PMID: 2983277

Diagnosis

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma: A Case Report and Literature Review.
Sakaguchi R, Yamada R, Nose K, Tanaka T, Murashima Y, Tsuboi J, Nakagawa H
Intern Med 2023 Nov 15;62(22):3347-3353. Epub 2023 Apr 7 doi: 10.2169/internalmedicine.1298-22. PMID: 37032087Free PMC Article
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL
World J Surg Oncol 2015 Nov 26;13:325. doi: 10.1186/s12957-015-0740-1. PMID: 26612593Free PMC Article
Intramucosal gastric mixed adenoneuroendocrine carcinoma completely resected with endoscopic submucosal dissection.
Yamasaki Y, Nasu J, Miura K, Kono Y, Kanzaki H, Hori K, Tanaka T, Kita M, Tsuzuki T, Matsubara M, Kawano S, Kawahara Y, Tabata M, Okada H, Yamamoto K
Intern Med 2015;54(8):917-20. Epub 2015 Apr 15 doi: 10.2169/internalmedicine.54.3469. PMID: 25876572

Therapy

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Endoscopic submucosal dissection using a thulium laser: preliminary results of a new method for treatment of gastric epithelial neoplasia.
Cho JH, Cho JY, Kim MY, Jeon SR, Lee TH, Kim HG, Jin SY, Hong SJ
Endoscopy 2013 Sep;45(9):725-8. Epub 2013 Jul 24 doi: 10.1055/s-0033-1344215. PMID: 23884792
Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report.
Ihtiyar E, Paşaoğlu O, Erkasap S, Karakaş BR, Yaşar FN
World J Surg Oncol 2010 Dec 22;8:110. doi: 10.1186/1477-7819-8-110. PMID: 21176192Free PMC Article
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Prognosis

Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst.
Ligthelm LJ, Bunn BK, Raubenheimer EJ, van Heerden WFP
Head Neck 2018 May;40(5):E53-E57. Epub 2018 Feb 23 doi: 10.1002/hed.25117. PMID: 29473257
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL
World J Surg Oncol 2015 Nov 26;13:325. doi: 10.1186/s12957-015-0740-1. PMID: 26612593Free PMC Article
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017
Adenocarcinoid tumor of the ampulla of Vater.
Alex WR, Auerbach HE, Pezzi CM
Am Surg 1998 Apr;64(4):355-9. PMID: 9544149

Clinical prediction guides

Multi-institutional development and validation of a nomogram to predict recurrence after curative resection of gastric neuroendocrine/mixed adenoneuroendocrine carcinoma.
Zheng H, Zhao Y, He Q, Hao H, Tian Y, Zou B, Jiang L, Qiu X, Zhou Y, Li Z, Xu Y, Zhao G, Xue F, Li S, Fu W, Li Y, Zhou X, Li Y, Zhu Z, Chen J, Xu Z, Cai L, Li E, Li H, Xie J, Zheng C, Lu J, Li P, Huang C
Gastric Cancer 2021 Mar;24(2):503-514. Epub 2020 Sep 11 doi: 10.1007/s10120-020-01119-8. PMID: 32915373
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Endoscopic submucosal dissection using a thulium laser: preliminary results of a new method for treatment of gastric epithelial neoplasia.
Cho JH, Cho JY, Kim MY, Jeon SR, Lee TH, Kim HG, Jin SY, Hong SJ
Endoscopy 2013 Sep;45(9):725-8. Epub 2013 Jul 24 doi: 10.1055/s-0033-1344215. PMID: 23884792
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
MicroRNA-223 in gastrointestinal cancers: A systematic review and diagnostic meta-analysis.
Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

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