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Morphine response

MedGen UID:
831768
Concept ID:
CN227914
Sign or Symptom
Synonym: Morphine sulfate response
Drug:
Morphine
MedGen UID:
31477
Concept ID:
C0066814
Pharmacologic Substance
The sulfate salt of morphine, an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions. In the central nervous and gastrointestinal systems, this agent has widespread effects including analgesia, anxiolysis, euphoria, sedation, respiratory depression, and gastrointestinal system smooth muscle contraction. [from NCI]

Professional guidelines

PubMed

Lavand'homme PM, Kehlet H, Rawal N, Joshi GP; PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA)
Eur J Anaesthesiol 2022 Sep 1;39(9):743-757. Epub 2022 Jul 20 doi: 10.1097/EJA.0000000000001691. PMID: 35852550Free PMC Article
Kreutzwiser D, Tawfic QA
CNS Drugs 2020 Aug;34(8):827-839. doi: 10.1007/s40263-020-00743-3. PMID: 32564328
McPherson C, Miller SP, El-Dib M, Massaro AN, Inder TE
Pediatr Res 2020 Aug;88(2):168-175. Epub 2020 Jan 2 doi: 10.1038/s41390-019-0744-6. PMID: 31896130Free PMC Article

Curated

DailyMed Drug Label, morphine, 2021

DailyMed Drug Label, MORPHINE SULFATE, 2013

Recent clinical studies

Etiology

Droney JM, Gretton SK, Sato H, Ross JR, Branford R, Welsh KI, Cookson W, Riley J
Br J Clin Pharmacol 2013 May;75(5):1340-50. doi: 10.1111/bcp.12008. PMID: 23072578Free PMC Article
Jimenez N, Anderson GD, Shen DD, Nielsen SS, Farin FM, Seidel K, Lynn AM
Paediatr Anaesth 2012 Jul;22(7):669-75. Epub 2012 Apr 4 doi: 10.1111/j.1460-9592.2012.03844.x. PMID: 22486937Free PMC Article
Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A
Anesth Analg 2011 Feb;112(2):448-53. Epub 2010 Dec 2 doi: 10.1213/ANE.0b013e318202cc8d. PMID: 21127283
Lynn AM, Nespeca MK, Bratton SL, Shen DD
Paediatr Anaesth 2003 Jan;13(1):12-7. doi: 10.1046/j.1460-9592.2003.00959.x. PMID: 12535033
Mercadante S, Casuccio A, Calderone L
J Clin Oncol 1999 Oct;17(10):3307-12. doi: 10.1200/JCO.1999.17.10.3307. PMID: 10506634

Diagnosis

Oladosu FA, Conrad MS, O'Buckley SC, Rashid NU, Slade GD, Nackley AG
PLoS One 2015;10(8):e0135711. Epub 2015 Aug 13 doi: 10.1371/journal.pone.0135711. PMID: 26270813Free PMC Article
Meng QC, Cepeda MS, Kramer T, Zou H, Matoka DJ, Farrar J
J Chromatogr B Biomed Sci Appl 2000 May 26;742(1):115-23. doi: 10.1016/s0378-4347(00)00146-8. PMID: 10892590

Therapy

Ladebo L, Olesen AE
Pharmacogenomics 2017 Nov;18(17):1553-1555. Epub 2017 Oct 24 doi: 10.2217/pgs-2017-0138. PMID: 29061085
Sverrisdóttir E, Lund TM, Olesen AE, Drewes AM, Christrup LL, Kreilgaard M
Eur J Pharm Sci 2015 Jul 10;74:45-62. Epub 2015 Apr 7 doi: 10.1016/j.ejps.2015.03.020. PMID: 25861720
Droney JM, Gretton SK, Sato H, Ross JR, Branford R, Welsh KI, Cookson W, Riley J
Br J Clin Pharmacol 2013 May;75(5):1340-50. doi: 10.1111/bcp.12008. PMID: 23072578Free PMC Article
Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A
Anesth Analg 2011 Feb;112(2):448-53. Epub 2010 Dec 2 doi: 10.1213/ANE.0b013e318202cc8d. PMID: 21127283
Coulbault L, Beaussier M, Verstuyft C, Weickmans H, Dubert L, Trégouet D, Descot C, Parc Y, Lienhart A, Jaillon P, Becquemont L
Clin Pharmacol Ther 2006 Apr;79(4):316-24. doi: 10.1016/j.clpt.2006.01.007. PMID: 16580900

Prognosis

Sverrisdóttir E, Lund TM, Olesen AE, Drewes AM, Christrup LL, Kreilgaard M
Eur J Pharm Sci 2015 Jul 10;74:45-62. Epub 2015 Apr 7 doi: 10.1016/j.ejps.2015.03.020. PMID: 25861720
Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A
Anesth Analg 2011 Feb;112(2):448-53. Epub 2010 Dec 2 doi: 10.1213/ANE.0b013e318202cc8d. PMID: 21127283
Coulbault L, Beaussier M, Verstuyft C, Weickmans H, Dubert L, Trégouet D, Descot C, Parc Y, Lienhart A, Jaillon P, Becquemont L
Clin Pharmacol Ther 2006 Apr;79(4):316-24. doi: 10.1016/j.clpt.2006.01.007. PMID: 16580900

Clinical prediction guides

Droney JM, Gretton SK, Sato H, Ross JR, Branford R, Welsh KI, Cookson W, Riley J
Br J Clin Pharmacol 2013 May;75(5):1340-50. doi: 10.1111/bcp.12008. PMID: 23072578Free PMC Article
Jimenez N, Anderson GD, Shen DD, Nielsen SS, Farin FM, Seidel K, Lynn AM
Paediatr Anaesth 2012 Jul;22(7):669-75. Epub 2012 Apr 4 doi: 10.1111/j.1460-9592.2012.03844.x. PMID: 22486937Free PMC Article
Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A
Anesth Analg 2011 Feb;112(2):448-53. Epub 2010 Dec 2 doi: 10.1213/ANE.0b013e318202cc8d. PMID: 21127283
Coulbault L, Beaussier M, Verstuyft C, Weickmans H, Dubert L, Trégouet D, Descot C, Parc Y, Lienhart A, Jaillon P, Becquemont L
Clin Pharmacol Ther 2006 Apr;79(4):316-24. doi: 10.1016/j.clpt.2006.01.007. PMID: 16580900
Huidobro F, Huidobro-Toro JP, Leong Way E
J Pharmacol Exp Ther 1976 Aug;198(2):318-29. PMID: 181557

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